ACON vs. OPK

Last updated Aug 1, 2026

ACON (Aclarion Inc) and OPK (OPKO Health, Inc.) are both stocks. Both are in the Healthcare sector — ACON in Health Information Services, OPK in Diagnostics & Research. Over the past 3 years, ACON returned -97.05%/yr vs -10.15%/yr for OPK. Their 0.09 correlation means their historical movements had little consistent relationship.

Performance

ACON vs. OPK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Aclarion Inc (ACON) and OPKO Health, Inc. (OPK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACON achieves a -51.09% return, which is significantly lower than OPK's 4.76% return.

ACON

• 1D: 11.39%
• 1M: -27.18%
• 6M: -32.02%
• YTD: -51.09%
• 1Y: -67.83%
• 3Y*: -97.05%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -94.16%

OPK

• 1D: -1.12%
• 1M: -13.16%
• 6M: 4.76%
• YTD: 4.76%
• 1Y: 10.92%
• 3Y*: -10.15%
• 5Y*: -17.43%
• 10Y*: -18.23%
• ALL TIME*: -3.91%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ACON Aclarion Inc	$113.15K	$104.31K	$202.81K
OPK OPKO Health, Inc.	$9.98M	$6.55M	$4.80M

ACON vs. OPK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
ACON Aclarion Inc	-51.09%	-99.65%	-95.50%	-65.52%	-80.00%
OPK OPKO Health, Inc.	4.76%	-14.29%	-2.65%	20.80%	-58.75%

Correlation

The correlation between ACON and OPK is 0.10, meaning there was essentially no consistent relationship between their historical price movements. Each responded to its own set of market drivers.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.10
Correlation (3Y) Balances recent behavior with more history.	0.07
Correlation (All Time) Calculated using the full available price history since Apr 22, 2022	0.09

Fundamentals

Market Cap ACON : $1.20M OPK : $985.15M
EPS ACON : -$7.44 OPK : -$0.10
PS Ratio ACON : 31.24 OPK : 1.72
PB Ratio ACON : 0.24 OPK : 0.84
Total Revenue (TTM) ACON : $77.88K OPK : $587.92M
Gross Profit (TTM) ACON : -$212.34K OPK : $248.53M
EBITDA (TTM) ACON : -$8.11M OPK : $27.50M

Return for Risk

ACON vs. OPK — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ACON

ACON Risk / Return Rank: 12
ACON Sharpe Ratio Rank: 12
ACON Sortino Ratio Rank: 12
ACON Omega Ratio Rank: 11
ACON Calmar Ratio Rank: 10
ACON Martin Ratio Rank: 13

OPK

OPK Risk / Return Rank: 47
OPK Sharpe Ratio Rank: 47
OPK Sortino Ratio Rank: 46
OPK Omega Ratio Rank: 47
OPK Calmar Ratio Rank: 47
OPK Martin Ratio Rank: 46

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ACON vs. OPK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Aclarion Inc (ACON) and OPKO Health, Inc. (OPK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ACON	OPK	Difference
Sharpe ratio: Return per unit of total volatility	-0.72	0.06	-0.78
Sortino ratio: Return per unit of downside risk	-1.03	0.53	-1.55
Omega ratio: Gain probability vs. loss probability	0.86	1.07	-0.21
Calmar ratio: Return relative to maximum drawdown	-0.86	0.10	-0.96
Martin ratio: Return relative to average drawdown	-1.27	0.18	-1.45

ACON vs. OPK - Sharpe Ratio Comparison

The current ACON Sharpe Ratio is -0.72, which is lower than the OPK Sharpe Ratio of 0.06. The chart below compares the historical Sharpe Ratios of ACON and OPK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ACON vs. OPK - Drawdown Comparison

The maximum ACON drawdown since its inception was -100.00%, roughly equal to the maximum OPK drawdown of -98.17%. Use the drawdown chart below to compare losses from any high point for ACON and OPK.

Drawdown Indicators

	ACON	OPK	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-98.17%	-1.83%
Max Drawdown (1Y) Largest decline over 1 year	-79.21%	-30.38%	-48.83%
Max Drawdown (3Y) Largest decline over 3 years	-100.00%	-56.51%	-43.49%
Max Drawdown (5Y) Largest decline over 5 years	—	-83.19%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-92.73%	—
Current Drawdown Current decline from peak	-100.00%	-93.10%	-6.90%
Average Drawdown Average peak-to-trough decline	-88.97%	-73.19%	-15.78%
Ulcer Index Depth and duration of drawdowns from previous peaks	53.27%	17.65%	+35.62%

Volatility

ACON vs. OPK - Volatility Comparison

The current volatility for Aclarion Inc (ACON) is 17.45%, while OPKO Health, Inc. (OPK) has a volatility of 37.43%. This indicates that ACON experiences smaller price fluctuations and is considered to be less risky than OPK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACON	OPK	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.45%	37.43%	-19.98%
Volatility (6M) Calculated over the trailing 6-month period	50.40%	44.22%	+6.18%
Volatility (1Y) Calculated over the trailing 1-year period	93.52%	53.83%	+39.69%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	170.08%	58.51%	+111.57%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	170.08%	65.81%	+104.27%

Dividends

ACON vs. OPK - Dividend Comparison

Neither ACON nor OPK has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACON and OPK in my portfolio?

ACON and OPK have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACON or OPK?

OPK has higher volatility (37.43%) compared to ACON (17.45%). In terms of maximum drawdown, ACON dropped -100.00% vs OPK's -98.17%.

Which has better risk-adjusted returns?

OPK currently has the higher Sharpe Ratio (0.06 vs -0.72), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.