ACON vs. OPK

Last updated Jun 3, 2026

ACON (Aclarion Inc) and OPK (OPKO Health, Inc.) are both stocks. Both are in the Healthcare sector — ACON in Health Information Services, OPK in Diagnostics & Research. Over the past 3 years, ACON returned -97.13%/yr vs -1.16%/yr for OPK. At a 0.09 correlation, their price movements are largely independent.

Performance

ACON vs. OPK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Aclarion Inc (ACON) and OPKO Health, Inc. (OPK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACON achieves a -23.91% return, which is significantly lower than OPK's 11.11% return.

ACON

• 1D: 3.86%
• 1M: 2.34%
• YTD: -23.91%
• 6M: -51.19%
• 1Y: -47.41%
• 3Y*: -97.13%
• 5Y*: —
• 10Y*: —

OPK

• 1D: 0.00%
• 1M: 27.27%
• YTD: 11.11%
• 6M: 5.26%
• 1Y: 1.45%
• 3Y*: -1.16%
• 5Y*: -17.53%
• 10Y*: -17.86%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ACON vs. OPK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
ACON Aclarion Inc	-23.91%	-99.65%	-95.50%	-65.52%	-78.68%
OPK OPKO Health, Inc.	11.11%	-14.29%	-2.65%	20.80%	-57.34%

Correlation

The correlation between ACON and OPK is 0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.07
Correlation (3Y) Calculated over the trailing 3-year period	0.07
Correlation (All Time) Calculated using the full available price history since Apr 25, 2022	0.09

Fundamentals

Market Cap ACON : $7.45M OPK : $1.06B
EPS ACON : -$8.41 OPK : -$0.29
PS Ratio ACON : 42.99 OPK : 1.79
PB Ratio ACON : 0.38 OPK : 0.88
Total Revenue (TTM) ACON : $77.88K OPK : $581.17M
Gross Profit (TTM) ACON : -$212.34K OPK : $277.22M
EBITDA (TTM) ACON : -$8.11M OPK : -$65.07M

Return for Risk

ACON vs. OPK — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ACON

ACON Risk / Return Rank: 20
ACON Sharpe Ratio Rank: 18
ACON Sortino Ratio Rank: 23
ACON Omega Ratio Rank: 22
ACON Calmar Ratio Rank: 18
ACON Martin Ratio Rank: 19

OPK

OPK Risk / Return Rank: 40
OPK Sharpe Ratio Rank: 42
OPK Sortino Ratio Rank: 37
OPK Omega Ratio Rank: 36
OPK Calmar Ratio Rank: 43
OPK Martin Ratio Rank: 42

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ACON vs. OPK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Aclarion Inc (ACON) and OPKO Health, Inc. (OPK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ACON	OPK	Difference
Sharpe ratio Return per unit of total volatility	-0.51	0.04	-0.55
Sortino ratio Return per unit of downside risk	-0.31	0.34	-0.65
Omega ratio Gain probability vs. loss probability	0.96	1.04	-0.08
Calmar ratio Return relative to maximum drawdown	-0.61	0.10	-0.70
Martin ratio Return relative to average drawdown	-1.02	0.17	-1.20
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ACON vs. OPK - Sharpe Ratio Comparison

The current ACON Sharpe Ratio is -0.51, which is lower than the OPK Sharpe Ratio of 0.04. The chart below compares the historical Sharpe Ratios of ACON and OPK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ACON	OPK	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.51	0.04	-0.55
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.31	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.28	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.54	-0.05	-0.50

Drawdowns

ACON vs. OPK - Drawdown Comparison

The maximum ACON drawdown since its inception was -100.00%, roughly equal to the maximum OPK drawdown of -98.17%. Use the drawdown chart below to compare losses from any high point for ACON and OPK.

Drawdown Indicators

	ACON	OPK	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-98.17%	-1.83%
Max Drawdown (1Y) Largest decline over 1 year	-75.64%	-30.38%	-45.26%
Max Drawdown (3Y) Largest decline over 3 years	-100.00%	-60.12%	-39.88%
Max Drawdown (5Y) Largest decline over 5 years	—	-83.19%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-92.73%	—
Current Drawdown Current decline from peak	-100.00%	-92.68%	-7.32%
Average Drawdown Average peak-to-trough decline	-87.86%	-73.09%	-14.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	45.05%	16.82%	+28.23%

Volatility

ACON vs. OPK - Volatility Comparison

The current volatility for Aclarion Inc (ACON) is 11.57%, while OPKO Health, Inc. (OPK) has a volatility of 13.60%. This indicates that ACON experiences smaller price fluctuations and is considered to be less risky than OPK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACON	OPK	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.57%	13.60%	-2.03%
Volatility (6M) Calculated over the trailing 6-month period	86.12%	26.76%	+59.36%
Volatility (1Y) Calculated over the trailing 1-year period	92.39%	37.54%	+54.85%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	173.13%	56.43%	+116.70%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	173.13%	64.77%	+108.36%

Dividends

ACON vs. OPK - Dividend Comparison

Neither ACON nor OPK has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACON and OPK in my portfolio?

ACON and OPK have a correlation of 0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACON or OPK?

OPK has higher volatility (13.60%) compared to ACON (11.57%). In terms of maximum drawdown, ACON dropped -100.00% vs OPK's -98.17%.

Which has better risk-adjusted returns?

OPK currently has the higher Sharpe Ratio (0.04 vs -0.51), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.