PortfoliosLab logo
Regulus Therapeutics Inc. (RGLS)
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN

US75915K2006

CUSIP

75915K200

IPO Date

Oct 4, 2012

Highlights

Market Cap

$549.03M

EPS (TTM)

-$0.68

PEG Ratio

-0.04

Total Revenue (TTM)

$340.00K

Gross Profit (TTM)

$81.00K

EBITDA (TTM)

-$48.08M

Year Range

$0.83 - $8.20

Target Price

$8.80

Short %

4.97%

Short Ratio

1.08

Share Price Chart


Loading data...

Compare to other instruments

Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.


Regulus Therapeutics Inc.

Popular comparisons:
RGLS vs. LLY
Popular comparisons:

Performance

Performance Chart


Loading data...

S&P 500

Returns By Period

Regulus Therapeutics Inc. (RGLS) returned 402.53% year-to-date (YTD) and 272.77% over the past 12 months. Over the past 10 years, RGLS returned -41.37% annually, underperforming the S&P 500 benchmark at 10.85%.


RGLS

YTD

402.53%

1M

135.61%

6M

384.15%

1Y

272.77%

3Y*

36.82%

5Y*

1.15%

10Y*

-41.37%

^GSPC (Benchmark)

YTD

0.51%

1M

6.15%

6M

-2.00%

1Y

12.92%

3Y*

12.68%

5Y*

14.19%

10Y*

10.85%

*Annualized

Monthly Returns

The table below presents the monthly returns of RGLS, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2025-36.71%35.00%29.63%356.00%-0.50%402.53%
2024-0.78%15.75%95.92%-20.14%-0.43%-22.05%0.84%-6.67%-6.55%-7.01%10.27%-1.86%23.44%
20235.11%-6.94%-36.75%57.52%-2.62%13.08%-4.76%11.43%-12.18%-11.68%8.26%-2.29%-6.57%
2022-21.68%-8.76%32.39%-32.38%42.18%-27.75%-22.22%-11.80%19.72%-8.82%10.32%-19.88%-56.51%
20212.96%-10.79%25.81%-10.90%-29.04%-17.56%-13.43%10.16%-10.94%-33.19%-16.02%-18.71%-76.67%
202021.35%-31.23%-37.93%10.63%47.06%-9.13%3.10%-24.57%-3.02%-8.37%33.78%114.25%51.69%
20191.01%37.23%-20.93%12.75%2.61%5.93%-51.11%2.21%15.27%-5.54%22.04%7.23%-4.36%
201814.42%-6.72%-35.36%-8.71%11.53%-9.76%-57.16%-17.95%-14.72%-25.35%-9.04%-42.20%-92.54%
2017-46.67%-12.50%57.14%-6.06%-9.68%-29.60%6.53%-4.76%25.00%-20.00%-9.01%14.30%-53.78%
2016-33.72%13.67%5.48%-15.73%5.14%-52.93%23.53%-11.20%4.10%-16.67%-10.91%-8.16%-74.20%
201519.39%-3.29%-8.53%-25.91%12.51%-22.38%-25.18%1.59%-21.49%1.68%51.43%-13.41%-45.64%
201423.14%23.41%-19.68%-20.95%-5.61%19.47%-20.52%7.67%-0.73%192.24%-6.11%-14.41%117.05%
Go deeper with the Portfolio Analysis tool — backtest performance, assess risk, compare to benchmarks, and more

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

With an overall rank of 95, RGLS is among the top 5% of stocks on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of RGLS is 9595
Overall Rank
The Sharpe Ratio Rank of RGLS is 9393
Sharpe Ratio Rank
The Sortino Ratio Rank of RGLS is 9898
Sortino Ratio Rank
The Omega Ratio Rank of RGLS is 9797
Omega Ratio Rank
The Calmar Ratio Rank of RGLS is 9696
Calmar Ratio Rank
The Martin Ratio Rank of RGLS is 9292
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for Regulus Therapeutics Inc. (RGLS) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

Regulus Therapeutics Inc. Sharpe ratios as of May 30, 2025 (values are recalculated daily):

  • 1-Year: 1.72
  • 5-Year: 0.01
  • 10-Year: -0.39
  • All Time: -0.27

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

The chart below shows the rolling Sharpe ratio of Regulus Therapeutics Inc. compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.


Loading data...

Go to the full Sharpe Ratio tool to analyze any stock or portfolio. Customize time frames, set your own risk-free rate, and more

Dividends

Dividend History


Regulus Therapeutics Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


Loading data...

Worst Drawdowns

The table below displays the maximum drawdowns of the Regulus Therapeutics Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Regulus Therapeutics Inc. was 99.97%, occurring on Mar 27, 2023. The portfolio has not yet recovered.

The current Regulus Therapeutics Inc. drawdown is 99.70%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-99.97%Nov 10, 20142108Mar 27, 2023
-53.26%Jul 12, 2013208May 8, 2014116Oct 22, 2014324
-25.98%Jan 3, 20138Jan 14, 201340Mar 13, 201348
-16.39%Apr 1, 201323May 1, 201319May 29, 201342
-15.76%Oct 26, 201233Dec 14, 20123Dec 19, 201236
Go to the full Drawdowns tool for more analysis options, including inflation-adjusted drawdowns, and more

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


Loading data...

Financials

Financial Performance

The chart below illustrates the trends in the financial health of Regulus Therapeutics Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Earnings Per Share

The chart presents the Earnings Per Share (EPS) performance of Regulus Therapeutics Inc., comparing actual results with analytics estimates. The company has exceeded analyst expectations for EPS in the past quarter, achieving a 43.4% positive surprise.


-2.50-2.00-1.50-1.00-0.500.0020212022202320242025
-0.15
-0.27
Actual
Estimate

Valuation

The Valuation section provides an overview of how Regulus Therapeutics Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PEG Ratio

The chart shows the Price/Earnings to Growth (PEG) ratio for RGLS compared to other companies in the Biotechnology industry. RGLS currently has a PEG ratio of -0.0. This PEG ratio is negative, which typically signals that the company's earnings are expected to decline. A negative PEG is not considered meaningful for valuation purposes.

PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for RGLS relative to other companies in the Biotechnology industry. Currently, RGLS has a P/S ratio of 7.4. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for RGLS in comparison with other companies in the Biotechnology industry. Currently, RGLS has a P/B value of 7.9. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items