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Protagonist Therapeutics Inc (PTGX)
Performance
Return for Risk
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN
US74366E1029
CUSIP
74366E102
IPO Date
Aug 11, 2016

Highlights

EPS (TTM)
$0.72
PE Ratio
146.11
Total Revenue (TTM)
$209.22M
Gross Profit (TTM)
$209.22M
EBITDA (TTM)
$27.53M
Year Range
$39.60 - $105.99
Target Price
$111.75
ROA (TTM)
6.87%
ROE (TTM)
7.47%

Share Price Chart


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Protagonist Therapeutics Inc

Often compared with PTGX:
PTGX vs. QQQ

Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Protagonist Therapeutics Inc, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


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S&P 500 Index

Returns By Period

Protagonist Therapeutics Inc (PTGX) has returned 20.68% so far this year and 117.95% over the past 12 months.


Protagonist Therapeutics Inc

1D
5.54%
1M
14.47%
YTD
20.68%
6M
58.66%
1Y
117.95%
3Y*
66.10%
5Y*
31.59%
10Y*

Benchmark (S&P 500 Index)

1D
2.91%
1M
-5.09%
YTD
-4.63%
6M
-2.39%
1Y
16.33%
3Y*
16.69%
5Y*
10.18%
10Y*
12.16%
*Multi-year figures are annualized to reflect compound growth (CAGR)

Monthly Returns

Based on dividend-adjusted daily data since Aug 11, 2016, PTGX's average daily return is +0.25%, while the average monthly return is +4.81%. At this rate, your investment would double in approximately 1.2 years.

Historically, 55% of months were positive and 45% were negative. The best month was May 2020 with a return of +144.9%, while the worst month was Sep 2021 at -63.5%. The longest winning streak lasted 7 consecutive months, and the longest losing streak was 6 months.

On a daily basis, PTGX closed higher 50% of trading days. The best single day was Oct 11, 2021 with a return of +93.9%, while the worst single day was Sep 17, 2021 at -62.0%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2026-6.34%12.57%14.47%20.68%
2025-2.07%-0.56%28.65%-5.25%3.60%16.43%-2.55%9.64%12.50%18.35%14.47%-2.96%126.27%
20249.07%21.47%-4.77%-13.20%12.11%23.09%8.05%14.56%4.92%1.87%-4.45%-11.87%68.34%
202321.81%22.05%41.80%-1.74%15.35%5.95%-29.76%2.16%-15.84%-12.83%25.24%25.92%110.17%
2022-14.36%-17.10%-2.47%-61.61%-3.63%-9.70%25.79%-12.36%-3.33%-3.91%-2.35%37.93%-68.10%
20212.73%13.81%9.89%11.74%21.32%27.83%10.14%-1.88%-63.46%75.85%7.89%1.73%69.64%

Benchmark Metrics

Protagonist Therapeutics Inc has an annualized alpha of 65.63%, beta of 1.01, and R² of 0.04 versus S&P 500 Index. Calculated based on daily prices since August 12, 2016.

  • This stock captured 240.87% of S&P 500 Index gains and 157.66% of its losses — amplifying both gains and losses, but participating more in upside than downside.
  • R² of 0.04 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
65.63%
Beta
1.01
0.04
Upside Capture
240.87%
Downside Capture
157.66%

Return for Risk

Risk / Return Rank

PTGX ranks 94 for risk / return — in the top 94% of stocks on our site. This means strong returns relative to risk — exactly what professional investors look for. Well-suited for investors who want to maximize return per unit of risk.


PTGX Risk / Return Rank: 9494
Overall Rank
PTGX Sharpe Ratio Rank: 9393
Sharpe Ratio Rank
PTGX Sortino Ratio Rank: 9393
Sortino Ratio Rank
PTGX Omega Ratio Rank: 9191
Omega Ratio Rank
PTGX Calmar Ratio Rank: 9696
Calmar Ratio Rank
PTGX Martin Ratio Rank: 9494
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics

The table below present risk-adjusted performance metrics for Protagonist Therapeutics Inc (PTGX) and compare them to a chosen benchmark (S&P 500 Index).


PTGXBenchmarkDifference

Sharpe ratio

Return per unit of total volatility

2.36

0.90

+1.47

Sortino ratio

Return per unit of downside risk

3.31

1.39

+1.92

Omega ratio

Gain probability vs. loss probability

1.42

1.21

+0.21

Calmar ratio

Return relative to maximum drawdown

7.06

1.40

+5.66

Martin ratio

Return relative to average drawdown

15.35

6.61

+8.75

Explore PTGX risk-adjusted metrics in detail

Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.

Dividends

Dividend History


Protagonist Therapeutics Inc doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Protagonist Therapeutics Inc. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Protagonist Therapeutics Inc was 85.79%, occurring on Jun 13, 2022. Recovery took 686 trading sessions.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-85.79%Sep 2, 2021196Jun 13, 2022686Mar 10, 2025882
-82.13%Dec 6, 2016753Dec 3, 2019302Feb 16, 20211055
-31.58%Mar 12, 202522Apr 10, 202595Aug 27, 2025117
-20.33%Oct 18, 201611Nov 1, 20167Nov 10, 201618
-19.04%Mar 22, 20216Mar 29, 202135May 18, 202141

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Protagonist Therapeutics Inc over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Valuation

The Valuation section provides an overview of how Protagonist Therapeutics Inc is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PE Ratio

The chart displays the Price-to-Earnings (P/E) ratio for PTGX, comparing it with other companies in the Biotechnology industry. Currently, PTGX has a P/E ratio of 146.1. This P/E ratio is significantly higher than those of industry peers. This could indicate that the stock is overvalued or that investors expect strong future growth.

PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for PTGX relative to other companies in the Biotechnology industry. Currently, PTGX has a P/S ratio of 32.1. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items