The Best Health & Biotech Equities ETFs
The table below compares the performance and other essential indicators like dividend yield and expense ratio of Health & Biotech Equities ETFs.
Health & Biotech Equities ETFs are exchange-traded funds that invest in a diversified portfolio of companies that operate in the healthcare and biotechnology sectors. These sectors include companies involved in the research, development, and production of medical products, drugs, and therapies. They can also include companies that provide healthcare services, such as hospitals, insurance companies, and medical device manufacturers.
Health & biotech ETFs can provide investors with exposure to the growth potential of these sectors, which are driven by factors such as demographic changes, technological advancements, and growing demand for healthcare services. However, it's important to note that these ETFs can be more volatile and risky than the overall market, as the success of many companies in this sector is heavily dependent on clinical trial results and regulatory approvals.
- Number of ETFs
- 66
- Avg. Expense Ratio
- 0.58%
- Avg. Dividend Yield
- 3.18%
- Avg. 1 Year Return
- 25.21%
- Median Risk/Return Score
- 37 / 100
The Best Health & Biotech Equities ETFs
66 results
Best Health & Biotech Equities ETFs by Risk/Return Score
The top Health & Biotech Equities ETFs by PortfoliosLab Risk/Return Score are BBC (88) and IHE (83).
The score measures risk-adjusted performance over the past year, accounting for volatility, drawdown, and return consistency.
| Symbol | Name | Risk / Return Rank | AUM | Inception |
|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 88 | 43.63M | Dec 2014 | |
| iShares U.S. Pharmaceuticals ETF | 83 | 912.87M | May 2006 | |
| First Trust Nasdaq Pharmaceuticals ETF | 81 | 35.04M | Sep 2016 | |
| Invesco Dynamic Pharmaceuticals ETF | 76 | 341.25M | Jun 2005 | |
| SPDR S&P Biotech ETF | 74 | 8.28B | Feb 2006 |
Best-Performing Health & Biotech Equities ETFs Over 5 Years
The top Health & Biotech Equities ETFs is IHE (10.63%).
Across the lineup, Health & Biotech Equities ETFs show an average 1-year return of 25.21% and an average 5-year return of 0.21%, providing a clearer view of performance across different investment horizons.
| Symbol | Name | Return 5Y | AUM | Inception |
|---|---|---|---|---|
| iShares U.S. Pharmaceuticals ETF | 10.63% | 912.87M | May 2006 | |
| Virtus LifeSci Biotech Products ETF | 10.41% | 78.56M | Dec 2014 | |
| VanEck Vectors Pharmaceutical ETF | 10.11% | 941.75M | Dec 2011 | |
| First Trust Nasdaq Pharmaceuticals ETF | 8.37% | 35.04M | Sep 2016 | |
| Invesco Dynamic Pharmaceuticals ETF | 8.32% | 341.25M | Jun 2005 |
Lowest-Cost Health & Biotech Equities ETFs
The top Health & Biotech Equities ETFs is XLV (0.08%).
With an average expense ratio of 0.58%, Health & Biotech Equities ETFs remain a low-cost option for investors seeking broad market exposure, sector allocations, and diversified portfolio building blocks.
| Symbol | Name | Expense Ratio | AUM | Inception |
|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.66B | Dec 1998 | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.85B | Oct 2013 | |
| Vanguard Health Care ETF | 0.09% | 18.50B | Jan 2004 | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | |
| GSK plc ADRhedged ETF | 0.19% | 701.89K | Jan 2025 |
Highest-Yield Health & Biotech Equities ETFs
The top Health & Biotech Equities ETFs is HIYY (94.23%).
Across the lineup, Health & Biotech Equities ETFs show an average dividend yield of 3.18%, offering investors a steady stream of income through regular dividend payments, making them attractive for income-seeking portfolios.
| Symbol | Name | Dividend Yield | AUM | Inception |
|---|---|---|---|---|
| YieldMax HIMS Option Income Strategy ETF | 94.23% | 7.54M | Sep 2025 | |
| Horizon Kinetics SPAC Active ETF | 16.25% | 10.01M | Jun 2007 | |
| Simplify Propel Opportunities ETF | 16.14% | 75.37M | Feb 2023 | |
| Roundhill UNH WeeklyPay ETF | 16.14% | 4.48M | Dec 2025 | |
| State Street Health Care Select Sector SPDR Premiu... | 11.28% | 14.25M | Jul 2025 |
Top ETFs Categories
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Top ETFs Comparisons
Compare the top ETFs symbols based on PortfoliosLab usage data.
XLV vs. SPYXLV vs. XLFXLV vs. VOOXLV vs. UNHXLV vs. NVOVHT vs. VGHCXVHT vs. VOOVHT vs. VGHAXVHT vs. IYHVHT vs. VGTXBI vs. LABUXBI vs. BBHXBI vs. VOOXBI vs. IBBQXBI vs. FBIOXIBB vs. IBBQIBB vs. BBHIBB vs. SPYIBB vs. FBIOXIBB vs. QQQFHLC vs. FSPHXFHLC vs. FSHCXFHLC vs. VOOFHLC vs. FTECFHLC vs. BKLCARKG vs. ARKKARKG vs. GNOMARKG vs. IDNAARKG vs. ARKQARKG vs. ARKWIHI vs. XHEIHI vs. SPYIHI vs. IHFIHI vs. VOOIHI vs. SPDPPH vs. XPHPPH vs. PJPPPH vs. FPHAXPPH vs. FTXHPPH vs. VOOIXJ vs. XDWH.LIXJ vs. IVVIXJ vs. HLTH.LIXJ vs. XTIXJ vs. XDWH.DEIHE vs. XPHIHE vs. VYMIHE vs. PJPIHE vs. IAKIHE vs. BBP
Risk vs. Return Scatterplot
The Risk vs. Return Scatterplot allows you to quickly compare funds, stocks, and ETFs in one view. It displays the yearly return of an instrument on one axis and the risk (volatility) on the other.
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5 Years