Asset Allocation
| Position | Category/Sector | Target Weight |
|---|---|---|
CORT Corcept Therapeutics Incorporated | Healthcare | 5% |
CPRX Catalyst Pharmaceuticals, Inc. | Healthcare | 9% |
EXEL Exelixis, Inc. | Healthcare | 9% |
GMAB Genmab A/S | Healthcare | 9% |
HALO Halozyme Therapeutics, Inc. | Healthcare | 9% |
HRMY Harmony Biosciences Holdings, Inc. | Healthcare | 9% |
JAZZ Jazz Pharmaceuticals plc | Healthcare | 9% |
LGND Ligand Pharmaceuticals Incorporated | Healthcare | 9% |
MDXG MiMedx Group, Inc. | Healthcare | 5% |
PBYI Puma Biotechnology, Inc. | Healthcare | 9% |
RPRX Royalty Pharma plc | Healthcare | 9% |
TECH Bio-Techne Corporation | Healthcare | 9% |
Performance
Performance Chart
The chart shows the growth of an initial investment of $10,000 in biotech, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends. The portfolio is rebalanced Every 3 months.
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The earliest data available for this chart is Aug 19, 2020, corresponding to the inception date of HRMY
Returns By Period
| 1D | 1M | YTD | 6M | 1Y | 3Y* | 5Y* | 10Y* | |
|---|---|---|---|---|---|---|---|---|
Benchmark S&P 500 Index | 0.80% | 4.83% | 2.59% | 5.27% | 30.14% | 19.29% | 10.91% | 12.94% |
Portfolio biotech | -0.83% | 10.35% | 5.31% | 11.12% | 40.62% | 20.23% | 11.62% | — |
| Portfolio components: | ||||||||
RPRX Royalty Pharma plc | -0.25% | 5.64% | 26.70% | 36.06% | 53.64% | 13.35% | 5.51% | — |
GMAB Genmab A/S | 0.83% | 10.32% | -4.87% | -10.45% | 50.18% | -11.01% | -3.62% | 7.57% |
EXEL Exelixis, Inc. | -3.45% | 7.82% | 1.03% | 10.62% | 21.18% | 31.53% | 13.42% | 26.12% |
TECH Bio-Techne Corporation | -0.29% | 19.83% | -0.41% | -1.56% | 15.20% | -11.33% | -10.58% | 10.37% |
JAZZ Jazz Pharmaceuticals plc | -0.86% | 9.51% | 17.25% | 46.78% | 93.69% | 11.06% | 3.37% | 3.25% |
HALO Halozyme Therapeutics, Inc. | 1.10% | 5.85% | 1.11% | 2.55% | 11.05% | 24.05% | 7.96% | 18.98% |
LGND Ligand Pharmaceuticals Incorporated | -3.12% | 8.32% | 19.05% | 22.80% | 110.76% | 44.67% | 8.42% | 6.09% |
CORT Corcept Therapeutics Incorporated | 0.50% | 36.42% | 26.15% | -42.85% | -36.92% | 25.57% | 14.04% | 24.52% |
CPRX Catalyst Pharmaceuticals, Inc. | -1.30% | 10.94% | 10.75% | 21.59% | 11.28% | 13.48% | 42.24% | 36.28% |
HRMY Harmony Biosciences Holdings, Inc. | -0.24% | 4.88% | -21.91% | 9.73% | 1.63% | -2.48% | 0.75% | — |
Monthly Returns
Based on dividend-adjusted daily data since Aug 20, 2020, biotech's average daily return is +0.07%, while the average monthly return is +1.32%. At this rate, an investment would double in approximately 4.4 years.
Historically, 54% of months were positive and 46% were negative. The best month was Nov 2022 with a return of +17.0%, while the worst month was Jan 2022 at -11.6%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 5 months.
On a daily basis, biotech closed higher 52% of trading days. The best single day was Nov 4, 2020 with a return of +6.5%, while the worst single day was May 9, 2022 at -7.3%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | 2.13% | -2.71% | -1.06% | 7.12% | 5.31% | ||||||||
| 2025 | 6.89% | 4.25% | -1.59% | -4.51% | 0.73% | -0.43% | 3.55% | 12.27% | 2.82% | 1.26% | 10.05% | -4.21% | 34.00% |
| 2024 | -6.35% | 8.49% | -0.95% | -7.17% | 4.77% | -0.76% | 11.20% | 0.29% | -0.87% | 1.21% | 8.46% | -5.05% | 11.91% |
| 2023 | -0.66% | -3.84% | -4.83% | -1.64% | 1.86% | 2.41% | 5.44% | 1.72% | -10.83% | -9.44% | 13.78% | 10.82% | 1.87% |
| 2022 | -11.58% | 5.08% | 9.32% | -5.99% | -5.46% | 5.78% | 9.25% | -2.66% | -7.98% | 8.23% | 16.96% | -4.93% | 12.47% |
| 2021 | 11.32% | -4.64% | 0.56% | 3.01% | -0.08% | 0.09% | -4.69% | 4.93% | -4.06% | 1.52% | -6.58% | 3.94% | 4.02% |
Benchmark Metrics
biotech has an annualized alpha of 4.03%, beta of 0.87, and R² of 0.37 versus S&P 500 Index. Calculated based on daily prices since August 20, 2020.
- This portfolio participates in less of S&P 500 Index's moves in both directions, but captures a larger share of gains (88.01%) than losses (82.65%) — typical of diversified or defensive assets.
- R² of 0.37 means the benchmark explains less than half of this portfolio's behavior — treat beta with caution or consider switching to a more representative benchmark.
- Alpha
- 4.03%
- Beta
- 0.87
- R²
- 0.37
- Upside Capture
- 88.01%
- Downside Capture
- 82.65%
Expense Ratio
biotech has an expense ratio of 0.00%, meaning no management fees are charged. Below, you can find the expense ratios of the portfolio's funds side by side and easily compare their relative costs.
Return for Risk
Risk / Return Rank
biotech ranks 29 for risk / return — below 29% of portfolios on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.
Return / Risk — by metrics
| Portfolio | Benchmark | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 1.92 | 2.30 | -0.38 |
Sortino ratioReturn per unit of downside risk | 2.57 | 3.18 | -0.61 |
Omega ratioGain probability vs. loss probability | 1.31 | 1.43 | -0.12 |
Calmar ratioReturn relative to maximum drawdown | 3.88 | 3.40 | +0.48 |
Martin ratioReturn relative to average drawdown | 12.11 | 15.35 | -3.25 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
How much return does each position deliver for the risk it carries? Higher values mean better reward for the risk taken.
| Risk / Return Rank | Sharpe ratio | Sortino ratio | Omega ratio | Calmar ratio | Martin ratio | |
|---|---|---|---|---|---|---|
RPRX Royalty Pharma plc | 89 | 2.46 | 3.14 | 1.42 | 7.59 | 18.26 |
GMAB Genmab A/S | 68 | 1.51 | 2.02 | 1.26 | 1.92 | 5.12 |
EXEL Exelixis, Inc. | 49 | 0.49 | 0.99 | 1.15 | 1.00 | 2.34 |
TECH Bio-Techne Corporation | 42 | 0.38 | 0.82 | 1.10 | 0.51 | 1.34 |
JAZZ Jazz Pharmaceuticals plc | 89 | 2.46 | 3.55 | 1.48 | 5.30 | 15.45 |
HALO Halozyme Therapeutics, Inc. | 39 | 0.26 | 0.62 | 1.11 | 0.41 | 0.86 |
LGND Ligand Pharmaceuticals Incorporated | 93 | 3.27 | 3.90 | 1.49 | 8.77 | 21.21 |
CORT Corcept Therapeutics Incorporated | 16 | -0.49 | -0.17 | 0.97 | -0.56 | -1.12 |
CPRX Catalyst Pharmaceuticals, Inc. | 41 | 0.34 | 0.68 | 1.09 | 0.63 | 1.15 |
HRMY Harmony Biosciences Holdings, Inc. | 32 | 0.04 | 0.33 | 1.05 | 0.01 | 0.01 |
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Dividends
Dividend yield
biotech provided a 0.21% dividend yield over the last twelve months.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Portfolio | 0.21% | 0.25% | 0.35% | 0.29% | 0.21% | 0.18% | 0.09% | 0.05% | 0.08% | 0.09% | 0.11% | 0.13% |
| Portfolio components: | ||||||||||||
RPRX Royalty Pharma plc | 1.84% | 2.28% | 3.29% | 2.85% | 1.92% | 1.71% | 0.60% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
GMAB Genmab A/S | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
EXEL Exelixis, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TECH Bio-Techne Corporation | 0.55% | 0.54% | 0.56% | 0.41% | 0.39% | 0.25% | 0.40% | 0.58% | 0.88% | 0.99% | 1.24% | 1.42% |
JAZZ Jazz Pharmaceuticals plc | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
HALO Halozyme Therapeutics, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
LGND Ligand Pharmaceuticals Incorporated | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
CORT Corcept Therapeutics Incorporated | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
CPRX Catalyst Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
HRMY Harmony Biosciences Holdings, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the biotech. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the biotech was 31.95%, occurring on May 11, 2022. Recovery took 142 trading sessions.
The current biotech drawdown is 1.11%.
Depth | Start | To Bottom | Bottom | To Recover | End | Total |
|---|---|---|---|---|---|---|
| -31.95% | Feb 10, 2021 | 316 | May 11, 2022 | 142 | Dec 2, 2022 | 458 |
| -25.91% | Dec 5, 2022 | 226 | Oct 27, 2023 | 82 | Feb 27, 2024 | 308 |
| -14.07% | Mar 3, 2025 | 27 | Apr 8, 2025 | 72 | Jul 23, 2025 | 99 |
| -11.98% | Feb 28, 2024 | 41 | Apr 25, 2024 | 55 | Jul 16, 2024 | 96 |
| -11.3% | Dec 26, 2025 | 63 | Mar 27, 2026 | — | — | — |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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Diversification
Diversification Metrics
Number of Effective Assets
The portfolio contains 12 assets, with an effective number of assets of 11.63, reflecting the diversification based on asset allocation. This number of effective assets suggests that the portfolio's investments are spread across a variety of assets, indicating a well-diversified allocation. However, true diversification also depends on the correlations between assets.
Asset Correlations Table
| Benchmark | RPRX | PBYI | MDXG | HRMY | CORT | GMAB | JAZZ | EXEL | TECH | LGND | CPRX | HALO | Portfolio | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benchmark | 1.00 | 0.31 | 0.27 | 0.40 | 0.32 | 0.35 | 0.36 | 0.38 | 0.34 | 0.52 | 0.40 | 0.39 | 0.38 | 0.56 |
| RPRX | 0.31 | 1.00 | 0.20 | 0.21 | 0.23 | 0.22 | 0.31 | 0.33 | 0.29 | 0.29 | 0.26 | 0.22 | 0.30 | 0.44 |
| PBYI | 0.27 | 0.20 | 1.00 | 0.27 | 0.27 | 0.24 | 0.25 | 0.26 | 0.31 | 0.22 | 0.30 | 0.33 | 0.26 | 0.60 |
| MDXG | 0.40 | 0.21 | 0.27 | 1.00 | 0.29 | 0.28 | 0.27 | 0.24 | 0.29 | 0.30 | 0.32 | 0.36 | 0.31 | 0.52 |
| HRMY | 0.32 | 0.23 | 0.27 | 0.29 | 1.00 | 0.30 | 0.27 | 0.29 | 0.26 | 0.29 | 0.32 | 0.35 | 0.36 | 0.60 |
| CORT | 0.35 | 0.22 | 0.24 | 0.28 | 0.30 | 1.00 | 0.28 | 0.27 | 0.32 | 0.32 | 0.34 | 0.34 | 0.35 | 0.54 |
| GMAB | 0.36 | 0.31 | 0.25 | 0.27 | 0.27 | 0.28 | 1.00 | 0.32 | 0.28 | 0.39 | 0.28 | 0.29 | 0.33 | 0.54 |
| JAZZ | 0.38 | 0.33 | 0.26 | 0.24 | 0.29 | 0.27 | 0.32 | 1.00 | 0.35 | 0.34 | 0.33 | 0.33 | 0.35 | 0.56 |
| EXEL | 0.34 | 0.29 | 0.31 | 0.29 | 0.26 | 0.32 | 0.28 | 0.35 | 1.00 | 0.30 | 0.34 | 0.39 | 0.37 | 0.57 |
| TECH | 0.52 | 0.29 | 0.22 | 0.30 | 0.29 | 0.32 | 0.39 | 0.34 | 0.30 | 1.00 | 0.36 | 0.28 | 0.39 | 0.57 |
| LGND | 0.40 | 0.26 | 0.30 | 0.32 | 0.32 | 0.34 | 0.28 | 0.33 | 0.34 | 0.36 | 1.00 | 0.41 | 0.35 | 0.61 |
| CPRX | 0.39 | 0.22 | 0.33 | 0.36 | 0.35 | 0.34 | 0.29 | 0.33 | 0.39 | 0.28 | 0.41 | 1.00 | 0.37 | 0.65 |
| HALO | 0.38 | 0.30 | 0.26 | 0.31 | 0.36 | 0.35 | 0.33 | 0.35 | 0.37 | 0.39 | 0.35 | 0.37 | 1.00 | 0.61 |
| Portfolio | 0.56 | 0.44 | 0.60 | 0.52 | 0.60 | 0.54 | 0.54 | 0.56 | 0.57 | 0.57 | 0.61 | 0.65 | 0.61 | 1.00 |