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XERS vs. VOO
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility

Correlation

The correlation between XERS and VOO is 0.30, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

XERS vs. VOO

Last updated Jun 1, 2025

Compare and contrast key facts about Xeris Biopharma Holdings, Inc. (XERS) and Vanguard S&P 500 ETF (VOO).

VOO is a passively managed fund by Vanguard that tracks the performance of the S&P 500 Index. It was launched on Sep 7, 2010.

Scroll down to visually compare performance, riskiness, drawdowns, and other indicators and decide which better suits your portfolio: XERS or VOO.

Performance

XERS vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Xeris Biopharma Holdings, Inc. (XERS) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

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Key characteristics

Sharpe Ratio

XERS:

2.22

VOO:

0.74

Sortino Ratio

XERS:

3.21

VOO:

1.04

Omega Ratio

XERS:

1.40

VOO:

1.15

Calmar Ratio

XERS:

1.69

VOO:

0.68

Martin Ratio

XERS:

13.87

VOO:

2.58

Ulcer Index

XERS:

11.34%

VOO:

4.93%

Daily Std Dev

XERS:

57.51%

VOO:

19.54%

Max Drawdown

XERS:

-96.22%

VOO:

-33.99%

Current Drawdown

XERS:

-81.86%

VOO:

-3.55%

Returns By Period

In the year-to-date period, XERS achieves a 45.72% return, which is significantly higher than VOO's 0.90% return.

XERS

YTD

45.72%

1M

10.27%

6M

50.61%

1Y

119.07%

3Y*

30.75%

5Y*

-0.79%

10Y*

N/A

VOO

YTD

0.90%

1M

5.53%

6M

-1.46%

1Y

13.29%

3Y*

14.31%

5Y*

15.89%

10Y*

12.81%

*Annualized

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Xeris Biopharma Holdings, Inc.

Vanguard S&P 500 ETF

Go deeper with the Portfolio Analysis tool — backtest performance, assess risk, compare to benchmarks, and more

Risk-Adjusted Performance

XERS vs. VOO — Risk-Adjusted Performance Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
XERS
The Risk-Adjusted Performance Rank of XERS is 9494
Overall Rank
The Sharpe Ratio Rank of XERS is 9696
Sharpe Ratio Rank
The Sortino Ratio Rank of XERS is 9595
Sortino Ratio Rank
The Omega Ratio Rank of XERS is 9393
Omega Ratio Rank
The Calmar Ratio Rank of XERS is 9090
Calmar Ratio Rank
The Martin Ratio Rank of XERS is 9797
Martin Ratio Rank
VOO
The Risk-Adjusted Performance Rank of VOO is 6363
Overall Rank
The Sharpe Ratio Rank of VOO is 6262
Sharpe Ratio Rank
The Sortino Ratio Rank of VOO is 6060
Sortino Ratio Rank
The Omega Ratio Rank of VOO is 6262
Omega Ratio Rank
The Calmar Ratio Rank of VOO is 6666
Calmar Ratio Rank
The Martin Ratio Rank of VOO is 6363
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

XERS vs. VOO - Risk-Adjusted Performance Comparison

This table presents a comparison of risk-adjusted performance metrics for Xeris Biopharma Holdings, Inc. (XERS) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

The current XERS Sharpe Ratio is 2.22, which is higher than the VOO Sharpe Ratio of 0.74. The chart below compares the historical Sharpe Ratios of XERS and VOO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

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Go to the full Sharpe Ratio tool to analyze any stock or portfolio. Customize time frames, set your own risk-free rate, and more

Dividends

XERS vs. VOO - Dividend Comparison

XERS has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.29%.

TTM20242023202220212020201920182017201620152014
XERS
Xeris Biopharma Holdings, Inc.		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
VOO
Vanguard S&P 500 ETF		1.29%1.24%1.46%1.69%1.25%1.54%1.88%2.06%1.78%2.02%2.10%1.85%

Drawdowns

XERS vs. VOO - Drawdown Comparison

The maximum XERS drawdown since its inception was -96.22%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for XERS and VOO.

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Go to the full Drawdowns tool for more analysis options, including inflation-adjusted drawdowns, and more

Volatility

XERS vs. VOO - Volatility Comparison

Xeris Biopharma Holdings, Inc. (XERS) has a higher volatility of 21.01% compared to Vanguard S&P 500 ETF (VOO) at 4.84%. This indicates that XERS's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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