VEXMX vs. AGIO

Last updated Jun 4, 2026

VEXMX (Vanguard Extended Market Index Fund) is Mid Cap Growth Equities fund managed by Vanguard, while AGIO (Agios Pharmaceuticals, Inc.) is a stock. Over the past 10 years, VEXMX returned 12.01%/yr vs -6.94%/yr for AGIO. At a 0.45 correlation, their price movements are largely independent.

Performance

VEXMX vs. AGIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vanguard Extended Market Index Fund (VEXMX) and Agios Pharmaceuticals, Inc. (AGIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VEXMX achieves a 14.86% return, which is significantly higher than AGIO's 1.69% return. Over the past 10 years, VEXMX has outperformed AGIO with an annualized return of 12.01%, while AGIO has yielded a comparatively lower -6.94% annualized return.

VEXMX

• 1D: 1.07%
• 1M: 5.79%
• YTD: 14.86%
• 6M: 13.58%
• 1Y: 29.96%
• 3Y*: 19.77%
• 5Y*: 6.66%
• 10Y*: 12.01%

AGIO

• 1D: 4.41%
• 1M: 0.44%
• YTD: 1.69%
• 6M: 0.69%
• 1Y: -17.05%
• 3Y*: 2.04%
• 5Y*: -13.63%
• 10Y*: -6.94%

*Multi-year figures are annualized to reflect compound growth (CAGR)

VEXMX vs. AGIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
VEXMX Vanguard Extended Market Index Fund	14.86%	10.93%	15.05%	26.79%	-26.56%	12.31%	32.43%	27.87%	-9.48%	17.94%
AGIO Agios Pharmaceuticals, Inc.	1.69%	-17.16%	47.55%	-20.69%	-14.57%	-24.14%	-9.26%	3.56%	-19.35%	37.00%

Correlation

The correlation between VEXMX and AGIO is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (3Y) Calculated over the trailing 3-year period	0.41
Correlation (5Y) Calculated over the trailing 5-year period	0.50
Correlation (10Y) Calculated over the trailing 10-year period	0.47
Correlation (All Time) Calculated using the full available price history since Jul 25, 2013	0.45

The correlation between VEXMX and AGIO shifts across timeframes, from 0.34 (1 year) to 0.50 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

VEXMX vs. AGIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VEXMX

VEXMX Risk / Return Rank: 47
VEXMX Sharpe Ratio Rank: 41
VEXMX Sortino Ratio Rank: 39
VEXMX Omega Ratio Rank: 36
VEXMX Calmar Ratio Rank: 65
VEXMX Martin Ratio Rank: 54

AGIO

AGIO Risk / Return Rank: 33
AGIO Sharpe Ratio Rank: 32
AGIO Sortino Ratio Rank: 37
AGIO Omega Ratio Rank: 40
AGIO Calmar Ratio Rank: 29
AGIO Martin Ratio Rank: 29

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VEXMX vs. AGIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vanguard Extended Market Index Fund (VEXMX) and Agios Pharmaceuticals, Inc. (AGIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	VEXMX	AGIO	Difference
Sharpe ratio Return per unit of total volatility	1.86	-0.23	+2.09
Sortino ratio Return per unit of downside risk	2.59	0.26	+2.33
Omega ratio Gain probability vs. loss probability	1.32	1.06	+0.26
Calmar ratio Return relative to maximum drawdown	3.11	-0.34	+3.45
Martin ratio Return relative to average drawdown	10.99	-0.61	+11.60
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

VEXMX vs. AGIO - Sharpe Ratio Comparison

The current VEXMX Sharpe Ratio is 1.86, which is higher than the AGIO Sharpe Ratio of -0.23. The chart below compares the historical Sharpe Ratios of VEXMX and AGIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	VEXMX	AGIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.86	-0.23	+2.09
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.30	-0.23	+0.53
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.54	-0.12	+0.66
Sharpe Ratio (All Time) Calculated using the full available price history	0.54	-0.01	+0.55

Drawdowns

VEXMX vs. AGIO - Drawdown Comparison

The maximum VEXMX drawdown since its inception was -58.17%, smaller than the maximum AGIO drawdown of -87.36%. Use the drawdown chart below to compare losses from any high point for VEXMX and AGIO.

Drawdown Indicators

	VEXMX	AGIO	Difference
Max Drawdown Largest peak-to-trough decline	-58.17%	-87.36%	+29.19%
Max Drawdown (1Y) Largest decline over 1 year	-10.27%	-50.89%	+40.62%
Max Drawdown (3Y) Largest decline over 3 years	-27.09%	-63.76%	+36.67%
Max Drawdown (5Y) Largest decline over 5 years	-36.38%	-72.16%	+35.78%
Max Drawdown (10Y) Largest decline over 10 years	-41.63%	-82.86%	+41.23%
Current Drawdown Current decline from peak	0.00%	-79.50%	+79.50%
Average Drawdown Average peak-to-trough decline	-11.15%	-58.83%	+47.68%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.90%	28.03%	-25.13%

Volatility

VEXMX vs. AGIO - Volatility Comparison

The current volatility for Vanguard Extended Market Index Fund (VEXMX) is 4.69%, while Agios Pharmaceuticals, Inc. (AGIO) has a volatility of 12.75%. This indicates that VEXMX experiences smaller price fluctuations and is considered to be less risky than AGIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VEXMX	AGIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.69%	12.75%	-8.06%
Volatility (6M) Calculated over the trailing 6-month period	12.46%	43.78%	-31.32%
Volatility (1Y) Calculated over the trailing 1-year period	17.17%	74.57%	-57.40%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.34%	58.80%	-36.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.39%	57.23%	-34.84%

Dividends

VEXMX vs. AGIO - Dividend Comparison

VEXMX's dividend yield for the trailing twelve months is around 0.89%, while AGIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AGIO Agios Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VEXMX Vanguard Extended Market Index Fund	0.89%	0.74%	0.74%	1.14%	1.00%	0.99%	1.19%	1.18%	1.52%	1.12%	1.31%	1.20%

Frequently Asked Questions

Can I hold both VEXMX and AGIO in my portfolio?

VEXMX and AGIO have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VEXMX or AGIO?

AGIO has higher volatility (12.75%) compared to VEXMX (4.69%). In terms of maximum drawdown, VEXMX dropped -58.17% vs AGIO's -87.36%.

Which has better risk-adjusted returns?

VEXMX currently has the higher Sharpe Ratio (1.86 vs -0.23), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.