TPST vs. TENX

Last updated Apr 1, 2026

Compare and contrast key facts about Tempest Therapeutics, Inc. (TPST) and Tenax Therapeutics, Inc. (TENX).

Performance

TPST vs. TENX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tempest Therapeutics, Inc. (TPST) and Tenax Therapeutics, Inc. (TENX). The values are adjusted to include any dividend payments, if applicable.

TPST vs. TENX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
TPST Tempest Therapeutics, Inc.	-42.86%	-73.54%	-81.03%	282.61%	-78.22%	-83.55%	-68.25%	-15.22%	-62.14%	-8.50%
TENX Tenax Therapeutics, Inc.	31.17%	96.93%	-71.82%	-87.67%	-89.29%	-44.09%	31.91%	16.53%	-87.65%	-74.87%

Fundamentals

Market Cap TPST : $6.81M TENX : $627.08M
EPS TPST : -$6.36 TENX : -$1.33
PB Ratio TPST : 1.02 TENX : 6.46
Total Revenue (TTM) TPST : $0.00 TENX : $0.00
Gross Profit (TTM) TPST : -$133.00K TENX : $0.00
EBITDA (TTM) TPST : -$10.27M TENX : $0.00

Returns By Period

In the year-to-date period, TPST achieves a -42.86% return, which is significantly lower than TENX's 31.17% return. Over the past 10 years, TPST has underperformed TENX with an annualized return of -62.01%, while TENX has yielded a comparatively higher -56.42% annualized return.

TPST

• 1D: 7.89%
• 1M: -28.07%
• YTD: -42.86%
• 6M: -84.05%
• 1Y: -82.91%
• 3Y*: -62.11%
• 5Y*: -63.34%
• 10Y*: -62.01%

TENX

• 1D: 14.13%
• 1M: 33.25%
• YTD: 31.17%
• 6M: 110.12%
• 1Y: 144.12%
• 3Y*: -24.53%
• 5Y*: -65.06%
• 10Y*: -56.42%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TPST vs. TENX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TPST

TPST Risk / Return Rank: 6
TPST Sharpe Ratio Rank: 9
TPST Sortino Ratio Rank: 7
TPST Omega Ratio Rank: 6
TPST Calmar Ratio Rank: 5
TPST Martin Ratio Rank: 5

TENX

TENX Risk / Return Rank: 90
TENX Sharpe Ratio Rank: 92
TENX Sortino Ratio Rank: 92
TENX Omega Ratio Rank: 90
TENX Calmar Ratio Rank: 89
TENX Martin Ratio Rank: 89

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TPST vs. TENX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tempest Therapeutics, Inc. (TPST) and Tenax Therapeutics, Inc. (TENX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TPST	TENX	Difference
Sharpe ratio Return per unit of total volatility	-0.80	2.15	-2.95
Sortino ratio Return per unit of downside risk	-1.39	3.10	-4.49
Omega ratio Gain probability vs. loss probability	0.80	1.39	-0.59
Calmar ratio Return relative to maximum drawdown	-0.96	3.53	-4.49
Martin ratio Return relative to average drawdown	-1.68	9.85	-11.53
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TPST vs. TENX - Sharpe Ratio Comparison

The current TPST Sharpe Ratio is -0.80, which is lower than the TENX Sharpe Ratio of 2.15. The chart below compares the historical Sharpe Ratios of TPST and TENX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	TPST	TENX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.80	2.15	-2.95
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.04	-0.39	+0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.05	-0.39	+0.34
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	-0.25	+0.21

Correlation

The correlation between TPST and TENX is 0.10, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

TPST vs. TENX - Dividend Comparison

Neither TPST nor TENX has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

TPST vs. TENX - Drawdown Comparison

The maximum TPST drawdown since its inception was -100.00%, roughly equal to the maximum TENX drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for TPST and TENX.

Drawdown Indicators

	TPST	TENX	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-100.00%	0.00%
Max Drawdown (1Y) Largest decline over 1 year	-87.15%	-41.49%	-45.66%
Max Drawdown (5Y) Largest decline over 5 years	-99.52%	-99.92%	+0.40%
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	-100.00%	0.00%
Current Drawdown Current decline from peak	-100.00%	-100.00%	0.00%
Average Drawdown Average peak-to-trough decline	-82.65%	-87.49%	+4.84%
Ulcer Index Depth and duration of drawdowns from previous peaks	49.91%	14.85%	+35.06%

Volatility

TPST vs. TENX - Volatility Comparison

The current volatility for Tempest Therapeutics, Inc. (TPST) is 29.88%, while Tenax Therapeutics, Inc. (TENX) has a volatility of 37.22%. This indicates that TPST experiences smaller price fluctuations and is considered to be less risky than TENX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TPST	TENX	Difference
Volatility (1M) Calculated over the trailing 1-month period	29.88%	37.22%	-7.34%
Volatility (6M) Calculated over the trailing 6-month period	92.95%	59.47%	+33.48%
Volatility (1Y) Calculated over the trailing 1-year period	103.55%	67.52%	+36.03%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	1,784.28%	165.40%	+1,618.88%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	1,262.43%	143.86%	+1,118.57%

Financials