TIL vs. SMMT

Last updated Jun 4, 2026

TIL (Instil Bio, Inc.) and SMMT (Summit Therapeutics Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, TIL returned -51.64%/yr vs 13.50%/yr for SMMT. At a 0.25 correlation, their price movements are largely independent.

Performance

TIL vs. SMMT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Instil Bio, Inc. (TIL) and Summit Therapeutics Inc. (SMMT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TIL achieves a -25.18% return, which is significantly lower than SMMT's -13.84% return.

TIL

• 1D: 1.48%
• 1M: 4.97%
• YTD: -25.18%
• 6M: -28.37%
• 1Y: -72.47%
• 3Y*: -10.93%
• 5Y*: -51.64%
• 10Y*: —

SMMT

• 1D: 1.41%
• 1M: -11.25%
• YTD: -13.84%
• 6M: -17.96%
• 1Y: -26.92%
• 3Y*: 102.68%
• 5Y*: 13.50%
• 10Y*: 5.76%

*Multi-year figures are annualized to reflect compound growth (CAGR)

TIL vs. SMMT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
TIL Instil Bio, Inc.	-25.18%	-42.38%	150.52%	-39.52%	-96.32%	-35.29%
SMMT Summit Therapeutics Inc.	-13.84%	-1.99%	583.72%	-38.59%	57.99%	-55.46%

Correlation

The correlation between TIL and SMMT is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (3Y) Calculated over the trailing 3-year period	0.28
Correlation (5Y) Calculated over the trailing 5-year period	0.25
Correlation (All Time) Calculated using the full available price history since Mar 22, 2021	0.25

Fundamentals

Market Cap TIL : $55.82M SMMT : $11.69B
EPS TIL : -$7.04 SMMT : -$1.60
PB Ratio TIL : 0.50 SMMT : 21.41
Total Revenue (TTM) TIL : $0.00 SMMT : $0.00
Gross Profit (TTM) TIL : -$12.00K SMMT : -$83.36K
EBITDA (TTM) TIL : -$45.96M SMMT : -$738.34M

Return for Risk

TIL vs. SMMT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TIL

TIL Risk / Return Rank: 10
TIL Sharpe Ratio Rank: 10
TIL Sortino Ratio Rank: 11
TIL Omega Ratio Rank: 10
TIL Calmar Ratio Rank: 7
TIL Martin Ratio Rank: 15

SMMT

SMMT Risk / Return Rank: 26
SMMT Sharpe Ratio Rank: 25
SMMT Sortino Ratio Rank: 29
SMMT Omega Ratio Rank: 29
SMMT Calmar Ratio Rank: 23
SMMT Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TIL vs. SMMT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Instil Bio, Inc. (TIL) and Summit Therapeutics Inc. (SMMT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TIL	SMMT	Difference
Sharpe ratio Return per unit of total volatility	-0.77	-0.36	-0.41
Sortino ratio Return per unit of downside risk	-1.04	-0.03	-1.01
Omega ratio Gain probability vs. loss probability	0.86	1.00	-0.14
Calmar ratio Return relative to maximum drawdown	-0.88	-0.51	-0.37
Martin ratio Return relative to average drawdown	-1.17	-0.80	-0.37
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TIL vs. SMMT - Sharpe Ratio Comparison

The current TIL Sharpe Ratio is -0.77, which is lower than the SMMT Sharpe Ratio of -0.36. The chart below compares the historical Sharpe Ratios of TIL and SMMT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TIL	SMMT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.77	-0.36	-0.41
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.48	0.07	-0.56
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.04	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.52	0.03	-0.54

Drawdowns

TIL vs. SMMT - Drawdown Comparison

The maximum TIL drawdown since its inception was -98.83%, roughly equal to the maximum SMMT drawdown of -95.75%. Use the drawdown chart below to compare losses from any high point for TIL and SMMT.

Drawdown Indicators

	TIL	SMMT	Difference
Max Drawdown Largest peak-to-trough decline	-98.83%	-95.75%	-3.08%
Max Drawdown (1Y) Largest decline over 1 year	-82.27%	-52.76%	-29.51%
Max Drawdown (3Y) Largest decline over 3 years	-92.12%	-62.26%	-29.86%
Max Drawdown (5Y) Largest decline over 5 years	-98.64%	-91.78%	-6.86%
Max Drawdown (10Y) Largest decline over 10 years	—	-95.75%	—
Current Drawdown Current decline from peak	-98.48%	-58.94%	-39.54%
Average Drawdown Average peak-to-trough decline	-82.57%	-57.64%	-24.93%
Ulcer Index Depth and duration of drawdowns from previous peaks	61.98%	33.88%	+28.10%

Volatility

TIL vs. SMMT - Volatility Comparison

The current volatility for Instil Bio, Inc. (TIL) is 4.10%, while Summit Therapeutics Inc. (SMMT) has a volatility of 22.87%. This indicates that TIL experiences smaller price fluctuations and is considered to be less risky than SMMT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TIL	SMMT	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.10%	22.87%	-18.77%
Volatility (6M) Calculated over the trailing 6-month period	69.31%	56.77%	+12.54%
Volatility (1Y) Calculated over the trailing 1-year period	94.43%	77.69%	+16.74%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	107.52%	185.11%	-77.59%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	106.74%	144.64%	-37.90%

Dividends

TIL vs. SMMT - Dividend Comparison

Neither TIL nor SMMT has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TIL and SMMT in my portfolio?

TIL and SMMT have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TIL or SMMT?

SMMT has higher volatility (22.87%) compared to TIL (4.10%). In terms of maximum drawdown, TIL dropped -98.83% vs SMMT's -95.75%.

Which has better risk-adjusted returns?

SMMT currently has the higher Sharpe Ratio (-0.36 vs -0.77), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.