SNY vs. NVO

Last updated Jun 3, 2026

SNY (Sanofi) and NVO (Novo Nordisk A/S) are both stocks. Both are in the Healthcare sector — SNY in Drug Manufacturers - General, NVO in Biotechnology. Over the past 10 years, SNY returned 4.63%/yr vs 6.45%/yr for NVO. At a 0.38 correlation, their price movements are largely independent.

Performance

SNY vs. NVO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Sanofi (SNY) and Novo Nordisk A/S (NVO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SNY achieves a -6.78% return, which is significantly higher than NVO's -12.70% return. Over the past 10 years, SNY has underperformed NVO with an annualized return of 4.63%, while NVO has yielded a comparatively higher 6.45% annualized return.

SNY

• 1D: -0.37%
• 1M: -1.96%
• YTD: -6.78%
• 6M: -9.38%
• 1Y: -8.16%
• 3Y*: -1.21%
• 5Y*: 0.44%
• 10Y*: 4.63%

NVO

• 1D: -2.61%
• 1M: -2.19%
• YTD: -12.70%
• 6M: -6.35%
• 1Y: -38.32%
• 3Y*: -16.12%
• 5Y*: 3.67%
• 10Y*: 6.45%

*Multi-year figures are annualized to reflect compound growth (CAGR)

SNY vs. NVO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
SNY Sanofi	-6.78%	4.93%	1.09%	6.55%	0.57%	7.00%	0.39%	20.47%	6.06%	9.96%
NVO Novo Nordisk A/S	-12.70%	-39.22%	-15.93%	54.84%	22.66%	63.52%	23.33%	28.70%	-12.98%	52.92%

Correlation

The correlation between SNY and NVO is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.24
Correlation (3Y) Calculated over the trailing 3-year period	0.27
Correlation (5Y) Calculated over the trailing 5-year period	0.30
Correlation (10Y) Calculated over the trailing 10-year period	0.37
Correlation (All Time) Calculated using the full available price history since Jul 2, 2002	0.38

The correlation between SNY and NVO shifts across timeframes, from 0.24 (1 year) to 0.38 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap SNY : $103.08B NVO : $190.94B
EPS SNY : $3.09 NVO : $27.42
PE Ratio SNY : 13.86 NVO : 1.57
PS Ratio SNY : 2.21 NVO : 0.58
PB Ratio SNY : 1.42 NVO : 0.94
Total Revenue (TTM) SNY : $47.35B NVO : $327.80B
Gross Profit (TTM) SNY : $34.18B NVO : $268.30B
EBITDA (TTM) SNY : $12.63B NVO : $181.54B

Return for Risk

SNY vs. NVO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SNY

SNY Risk / Return Rank: 23
SNY Sharpe Ratio Rank: 27
SNY Sortino Ratio Rank: 24
SNY Omega Ratio Rank: 23
SNY Calmar Ratio Rank: 23
SNY Martin Ratio Rank: 19

NVO

NVO Risk / Return Rank: 14
NVO Sharpe Ratio Rank: 10
NVO Sortino Ratio Rank: 13
NVO Omega Ratio Rank: 11
NVO Calmar Ratio Rank: 15
NVO Martin Ratio Rank: 20

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SNY vs. NVO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Sanofi (SNY) and Novo Nordisk A/S (NVO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SNY	NVO	Difference
Sharpe ratio Return per unit of total volatility	-0.33	-0.74	+0.41
Sortino ratio Return per unit of downside risk	-0.28	-0.85	+0.56
Omega ratio Gain probability vs. loss probability	0.96	0.88	+0.09
Calmar ratio Return relative to maximum drawdown	-0.51	-0.68	+0.17
Martin ratio Return relative to average drawdown	-1.01	-1.01	0.00
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SNY vs. NVO - Sharpe Ratio Comparison

The current SNY Sharpe Ratio is -0.33, which is higher than the NVO Sharpe Ratio of -0.74. The chart below compares the historical Sharpe Ratios of SNY and NVO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	SNY	NVO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.33	-0.74	+0.41
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.02	0.10	-0.08
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.20	0.20	0.00
Sharpe Ratio (All Time) Calculated using the full available price history	0.20	0.47	-0.27

Drawdowns

SNY vs. NVO - Drawdown Comparison

The maximum SNY drawdown since its inception was -46.46%, smaller than the maximum NVO drawdown of -74.70%. Use the drawdown chart below to compare losses from any high point for SNY and NVO.

Drawdown Indicators

	SNY	NVO	Difference
Max Drawdown Largest peak-to-trough decline	-46.46%	-74.70%	+28.24%
Max Drawdown (1Y) Largest decline over 1 year	-16.70%	-55.03%	+38.33%
Max Drawdown (3Y) Largest decline over 3 years	-23.37%	-74.70%	+51.33%
Max Drawdown (5Y) Largest decline over 5 years	-33.52%	-74.70%	+41.18%
Max Drawdown (10Y) Largest decline over 10 years	-33.52%	-74.70%	+41.18%
Current Drawdown Current decline from peak	-20.60%	-68.81%	+48.21%
Average Drawdown Average peak-to-trough decline	-12.19%	-17.75%	+5.56%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.39%	36.77%	-28.38%

Volatility

SNY vs. NVO - Volatility Comparison

The current volatility for Sanofi (SNY) is 5.39%, while Novo Nordisk A/S (NVO) has a volatility of 7.70%. This indicates that SNY experiences smaller price fluctuations and is considered to be less risky than NVO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SNY	NVO	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.39%	7.70%	-2.31%
Volatility (6M) Calculated over the trailing 6-month period	14.94%	37.81%	-22.87%
Volatility (1Y) Calculated over the trailing 1-year period	24.93%	51.76%	-26.83%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.68%	38.20%	-13.52%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.42%	32.49%	-9.07%

Dividends

SNY vs. NVO - Dividend Comparison

SNY's dividend yield for the trailing twelve months is around 5.66%, more than NVO's 4.20% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
NVO Novo Nordisk A/S	4.20%	3.31%	1.68%	1.00%	1.20%	1.35%	1.87%	2.14%	1.45%	1.52%	2.87%	0.92%
SNY Sanofi	5.66%	4.56%	4.22%	3.83%	4.32%	3.80%	3.61%	3.47%	4.29%	3.82%	4.11%	3.77%

Financials

SNY vs. NVO - Profitability Comparison

The chart below illustrates the profitability comparison between Sanofi and Novo Nordisk A/S over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

SNY - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Sanofi reported a gross profit of 8.11B and revenue of 11.24B. Therefore, the gross margin over that period was 72.1%.

NVO - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Novo Nordisk A/S reported a gross profit of 83.23B and revenue of 96.82B. Therefore, the gross margin over that period was 86.0%.

SNY - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Sanofi reported an operating income of 2.27B and revenue of 11.24B, resulting in an operating margin of 20.2%.

NVO - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Novo Nordisk A/S reported an operating income of 59.62B and revenue of 96.82B, resulting in an operating margin of 61.6%.

SNY - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Sanofi reported a net income of 1.61B and revenue of 11.24B, resulting in a net margin of 14.4%.

NVO - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Novo Nordisk A/S reported a net income of 48.56B and revenue of 96.82B, resulting in a net margin of 50.2%.

Frequently Asked Questions

Can I hold both SNY and NVO in my portfolio?

SNY and NVO have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SNY or NVO?

NVO has higher volatility (7.70%) compared to SNY (5.39%). In terms of maximum drawdown, SNY dropped -46.46% vs NVO's -74.70%.

Which has better risk-adjusted returns?

SNY currently has the higher Sharpe Ratio (-0.33 vs -0.74), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.