SANA vs. SMH

Last updated Aug 1, 2026

SANA (Sana Biotechnology, Inc.) is a stock, while SMH (VanEck Semiconductor ETF) is Semiconductors fund tracking the MVIS US Listed Semiconductor 25 Index. Over the past 5 years, SANA returned -28.10%/yr vs 33.46%/yr for SMH. Their 0.32 correlation means their historical movements had little consistent relationship.

Performance

SANA vs. SMH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SANA achieves a -23.10% return, which is significantly lower than SMH's 50.09% return.

SANA

• 1D: -3.69%
• 1M: -21.95%
• 6M: -29.35%
• YTD: -23.10%
• 1Y: -19.95%
• 3Y*: -18.25%
• 5Y*: -28.10%
• 10Y*: —
• ALL TIME*: -35.61%

SMH

• 1D: 0.30%
• 1M: -8.74%
• 6M: 33.97%
• YTD: 50.09%
• 1Y: 90.95%
• 3Y*: 50.56%
• 5Y*: 33.46%
• 10Y*: 34.16%
• ALL TIME*: 11.06%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
SANA Sana Biotechnology, Inc.	$7.94M	$9.87M	$11.93M
SMH VanEck Semiconductor ETF	$8.28B	$7.64B	$7.07B

SANA vs. SMH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
SANA Sana Biotechnology, Inc.	-23.10%	149.69%	-60.05%	3.29%	-74.48%	-55.77%
SMH VanEck Semiconductor ETF	50.09%	49.17%	39.10%	73.38%	-33.53%	32.54%

Correlation

The correlation between SANA and SMH is 0.28, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.28
Correlation (3Y) Balances recent behavior with more history.	0.26
Correlation (5Y) Shows whether the relationship held over a longer period.	0.33
Correlation (All Time) Calculated using the full available price history since Feb 4, 2021	0.32

Return for Risk

SANA vs. SMH — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

SANA

SANA Risk / Return Rank: 34
SANA Sharpe Ratio Rank: 33
SANA Sortino Ratio Rank: 39
SANA Omega Ratio Rank: 39
SANA Calmar Ratio Rank: 30
SANA Martin Ratio Rank: 32

SMH

SMH Risk / Return Rank: 87
SMH Sharpe Ratio Rank: 91
SMH Sortino Ratio Rank: 83
SMH Omega Ratio Rank: 84
SMH Calmar Ratio Rank: 88
SMH Martin Ratio Rank: 91

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

SANA vs. SMH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SANA	SMH	Difference
Sharpe ratio: Return per unit of total volatility	-0.26	2.29	-2.55
Sortino ratio: Return per unit of downside risk	0.24	2.70	-2.46
Omega ratio: Gain probability vs. loss probability	1.03	1.36	-0.33
Calmar ratio: Return relative to maximum drawdown	-0.42	3.58	-4.00
Martin ratio: Return relative to average drawdown	-0.66	14.64	-15.30

SANA vs. SMH - Sharpe Ratio Comparison

The current SANA Sharpe Ratio is -0.26, which is lower than the SMH Sharpe Ratio of 2.29. The chart below compares the historical Sharpe Ratios of SANA and SMH, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SANA vs. SMH - Drawdown Comparison

The maximum SANA drawdown since its inception was -96.92%, which is greater than SMH's maximum drawdown of -84.96%. Use the drawdown chart below to compare losses from any high point for SANA and SMH.

Drawdown Indicators

	SANA	SMH	Difference
Max Drawdown Largest peak-to-trough decline	-96.92%	-84.96%	-11.96%
Max Drawdown (1Y) Largest decline over 1 year	-54.73%	-24.62%	-30.11%
Max Drawdown (3Y) Largest decline over 3 years	-88.11%	-35.74%	-52.37%
Max Drawdown (5Y) Largest decline over 5 years	-94.82%	-45.30%	-49.52%
Max Drawdown (10Y) Largest decline over 10 years	—	-45.30%	—
Current Drawdown Current decline from peak	-92.80%	-19.19%	-73.61%
Average Drawdown Average peak-to-trough decline	-81.73%	-40.89%	-40.84%
Ulcer Index Depth and duration of drawdowns from previous peaks	34.77%	6.01%	+28.76%

Volatility

SANA vs. SMH - Volatility Comparison

Sana Biotechnology, Inc. (SANA) has a higher volatility of 20.12% compared to VanEck Semiconductor ETF (SMH) at 14.70%. This indicates that SANA's price experiences larger fluctuations and is considered to be riskier than SMH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SANA	SMH	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.12%	14.70%	+5.42%
Volatility (6M) Calculated over the trailing 6-month period	48.77%	33.13%	+15.64%
Volatility (1Y) Calculated over the trailing 1-year period	90.12%	38.57%	+51.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	118.37%	36.50%	+81.87%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	116.09%	33.32%	+82.77%

Dividends

SANA vs. SMH - Dividend Comparison

SANA has not paid dividends to shareholders, while SMH's dividend yield for the trailing twelve months is around 0.20%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SANA Sana Biotechnology, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SMH VanEck Semiconductor ETF	0.20%	0.31%	0.44%	0.60%	1.18%	0.51%	0.69%	1.50%	1.88%	1.43%	0.80%	2.14%

Frequently Asked Questions

Can I hold both SANA and SMH in my portfolio?

SANA and SMH have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SANA or SMH?

SANA has higher volatility (20.12%) compared to SMH (14.70%). In terms of maximum drawdown, SANA dropped -96.92% vs SMH's -84.96%.

Which has better risk-adjusted returns?

SMH currently has the higher Sharpe Ratio (2.29 vs -0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.