SANA vs. SMH
SANA (Sana Biotechnology, Inc.) is a stock, while SMH (VanEck Semiconductor ETF) is Semiconductors fund tracking the MVIS US Listed Semiconductor 25 Index. Over the past 5 years, SANA returned -26.88%/yr vs 36.02%/yr for SMH. At a 0.32 correlation, their price movements are largely independent.
Performance
SANA vs. SMH - Performance Comparison
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Returns By Period
In the year-to-date period, SANA achieves a -10.57% return, which is significantly lower than SMH's 62.61% return.
SANA
- 1D
- -5.45%
- 1M
- 35.82%
- 6M
- -20.52%
- YTD
- -10.57%
- 1Y
- -12.92%
- 3Y*
- -14.28%
- 5Y*
- -26.88%
- 10Y*
- —
SMH
- 1D
- -4.16%
- 1M
- -5.54%
- 6M
- 49.91%
- YTD
- 62.61%
- 1Y
- 104.33%
- 3Y*
- 55.82%
- 5Y*
- 36.02%
- 10Y*
- 35.93%
SANA vs. SMH - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
SANA Sana Biotechnology, Inc. | -10.57% | 149.69% | -60.05% | 3.29% | -74.48% | -55.77% |
SMH VanEck Semiconductor ETF | 62.61% | 49.17% | 39.10% | 73.38% | -33.53% | 32.54% |
Correlation
The correlation between SANA and SMH is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.26 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.26 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.33 |
Correlation (All Time) Calculated using the full available price history since Feb 4, 2021 | 0.32 |
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Return for Risk
SANA vs. SMH — Risk / Return Rank
SANA
SMH
SANA vs. SMH - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SANA | SMH | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -3.00 | ||
| Sortino ratioReturn per unit of downside risk | -2.69 | ||
| Omega ratioGain probability vs. loss probability | 1.06 | 1.43 | -0.38 |
| Calmar ratioReturn relative to maximum drawdown | -0.24 | 7.03 | -7.26 |
| Martin ratioReturn relative to average drawdown | -0.37 | 22.83 | -23.19 |
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Drawdowns
SANA vs. SMH - Drawdown Comparison
The maximum SANA drawdown since its inception was -96.92%, which is greater than SMH's maximum drawdown of -84.96%. Use the drawdown chart below to compare losses from any high point for SANA and SMH.
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Drawdown Indicators
| SANA | SMH | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -96.92% | -84.96% | -11.96% |
Max Drawdown (1Y)Largest decline over 1 year | -54.73% | -14.93% | -39.80% |
Max Drawdown (3Y)Largest decline over 3 years | -88.11% | -35.74% | -52.37% |
Max Drawdown (5Y)Largest decline over 5 years | -94.82% | -45.30% | -49.52% |
Max Drawdown (10Y)Largest decline over 10 years | — | -45.30% | — |
Current DrawdownCurrent decline from peak | -91.63% | -12.45% | -79.18% |
Average DrawdownAverage peak-to-trough decline | -81.62% | -40.94% | -40.68% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 35.16% | 4.59% | +30.57% |
Volatility
SANA vs. SMH - Volatility Comparison
Sana Biotechnology, Inc. (SANA) has a higher volatility of 19.62% compared to VanEck Semiconductor ETF (SMH) at 18.45%. This indicates that SANA's price experiences larger fluctuations and is considered to be riskier than SMH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SANA | SMH | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 19.62% | 18.45% | +1.17% |
Volatility (6M)Calculated over the trailing 6-month period | 48.09% | 31.29% | +16.80% |
Volatility (1Y)Calculated over the trailing 1-year period | 90.85% | 36.76% | +54.09% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 118.44% | 36.19% | +82.25% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 116.54% | 33.14% | +83.40% |
Dividends
SANA vs. SMH - Dividend Comparison
SANA has not paid dividends to shareholders, while SMH's dividend yield for the trailing twelve months is around 0.19%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SANA Sana Biotechnology, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
SMH VanEck Semiconductor ETF | 0.19% | 0.31% | 0.44% | 0.60% | 1.18% | 0.51% | 0.69% | 1.50% | 1.88% | 1.43% | 0.80% | 2.14% |
Frequently Asked Questions
SANA and SMH have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SANA has higher volatility (19.62%) compared to SMH (18.45%). In terms of maximum drawdown, SANA dropped -96.92% vs SMH's -84.96%.
SMH currently has the higher Sharpe Ratio (2.86 vs -0.14), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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