SANA vs. SMH

Last updated Apr 2, 2026

Compare and contrast key facts about Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH).

SMH is a passively managed fund by VanEck that tracks the performance of the MVIS US Listed Semiconductor 25 Index. It was launched on Dec 20, 2011.

Performance

SANA vs. SMH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH). The values are adjusted to include any dividend payments, if applicable.

SANA vs. SMH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
SANA Sana Biotechnology, Inc.	-25.06%	149.69%	-60.05%	3.29%	-74.48%	-55.90%
SMH VanEck Semiconductor ETF	8.84%	49.17%	39.10%	73.38%	-33.53%	31.03%

Returns By Period

In the year-to-date period, SANA achieves a -25.06% return, which is significantly lower than SMH's 8.84% return.

SANA

• 1D: 5.90%
• 1M: -26.51%
• YTD: -25.06%
• 6M: -17.57%
• 1Y: 103.33%
• 3Y*: -2.29%
• 5Y*: -37.51%
• 10Y*: —

SMH

• 1D: 2.24%
• 1M: -3.55%
• YTD: 8.84%
• 6M: 17.83%
• 1Y: 85.04%
• 3Y*: 44.53%
• 5Y*: 26.15%
• 10Y*: 31.58%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

SANA vs. SMH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SANA

SANA Risk / Return Rank: 72
SANA Sharpe Ratio Rank: 73
SANA Sortino Ratio Rank: 77
SANA Omega Ratio Rank: 72
SANA Calmar Ratio Rank: 70
SANA Martin Ratio Rank: 67

SMH

SMH Risk / Return Rank: 95
SMH Sharpe Ratio Rank: 94
SMH Sortino Ratio Rank: 93
SMH Omega Ratio Rank: 92
SMH Calmar Ratio Rank: 97
SMH Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SANA vs. SMH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Sana Biotechnology, Inc. (SANA) and VanEck Semiconductor ETF (SMH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SANA	SMH	Difference
Sharpe ratio Return per unit of total volatility	0.98	2.32	-1.34
Sortino ratio Return per unit of downside risk	1.97	2.92	-0.95
Omega ratio Gain probability vs. loss probability	1.24	1.41	-0.17
Calmar ratio Return relative to maximum drawdown	1.49	5.39	-3.90
Martin ratio Return relative to average drawdown	3.07	19.22	-16.15
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SANA vs. SMH - Sharpe Ratio Comparison

The current SANA Sharpe Ratio is 0.98, which is lower than the SMH Sharpe Ratio of 2.32. The chart below compares the historical Sharpe Ratios of SANA and SMH, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	SANA	SMH	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.98	2.32	-1.34
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.32	0.76	-1.07
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.98	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.32	0.28	-0.60

Correlation

The correlation between SANA and SMH is 0.34, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

SANA vs. SMH - Dividend Comparison

SANA has not paid dividends to shareholders, while SMH's dividend yield for the trailing twelve months is around 0.28%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SANA Sana Biotechnology, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SMH VanEck Semiconductor ETF	0.28%	0.31%	0.44%	0.60%	1.18%	0.51%	0.69%	1.50%	1.88%	1.43%	0.80%	2.14%

Drawdowns

SANA vs. SMH - Drawdown Comparison

The maximum SANA drawdown since its inception was -96.92%, which is greater than SMH's maximum drawdown of -84.96%. Use the drawdown chart below to compare losses from any high point for SANA and SMH.

Drawdown Indicators

	SANA	SMH	Difference
Max Drawdown Largest peak-to-trough decline	-96.92%	-84.96%	-11.96%
Max Drawdown (1Y) Largest decline over 1 year	-54.73%	-15.95%	-38.78%
Max Drawdown (5Y) Largest decline over 5 years	-95.83%	-45.30%	-50.53%
Max Drawdown (10Y) Largest decline over 10 years	—	-45.30%	—
Current Drawdown Current decline from peak	-92.99%	-8.02%	-84.97%
Average Drawdown Average peak-to-trough decline	-81.10%	-41.35%	-39.75%
Ulcer Index Depth and duration of drawdowns from previous peaks	26.57%	4.47%	+22.10%

Volatility

SANA vs. SMH - Volatility Comparison

Sana Biotechnology, Inc. (SANA) has a higher volatility of 24.65% compared to VanEck Semiconductor ETF (SMH) at 11.74%. This indicates that SANA's price experiences larger fluctuations and is considered to be riskier than SMH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SANA	SMH	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.65%	11.74%	+12.91%
Volatility (6M) Calculated over the trailing 6-month period	67.60%	24.02%	+43.58%
Volatility (1Y) Calculated over the trailing 1-year period	106.47%	36.88%	+69.59%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	118.85%	34.68%	+84.17%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	118.78%	32.29%	+86.49%