PRFX vs. FNDX

Last updated Apr 1, 2026

Compare and contrast key facts about PainReform Ltd. (PRFX) and Schwab Fundamental U.S. Large Company Index ETF (FNDX).

FNDX is a passively managed fund by Charles Schwab that tracks the performance of the Russell Fundamental U.S. Large Company Index. It was launched on Aug 15, 2013.

Performance

PRFX vs. FNDX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in PainReform Ltd. (PRFX) and Schwab Fundamental U.S. Large Company Index ETF (FNDX). The values are adjusted to include any dividend payments, if applicable.

PRFX vs. FNDX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
PRFX PainReform Ltd.	-36.90%	-80.87%	-94.92%	-33.37%	-68.97%	-70.25%	-33.68%
FNDX Schwab Fundamental U.S. Large Company Index ETF	2.76%	16.94%	16.77%	18.23%	-6.92%	31.73%	12.37%

Returns By Period

In the year-to-date period, PRFX achieves a -36.90% return, which is significantly lower than FNDX's 2.76% return.

PRFX

• 1D: 7.14%
• 1M: -31.82%
• YTD: -36.90%
• 6M: -71.07%
• 1Y: -81.25%
• 3Y*: -86.53%
• 5Y*: -79.53%
• 10Y*: —

FNDX

• 1D: 1.98%
• 1M: -3.68%
• YTD: 2.76%
• 6M: 6.80%
• 1Y: 19.99%
• 3Y*: 17.12%
• 5Y*: 11.99%
• 10Y*: 13.26%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PRFX vs. FNDX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PRFX

PRFX Risk / Return Rank: 7
PRFX Sharpe Ratio Rank: 13
PRFX Sortino Ratio Rank: 5
PRFX Omega Ratio Rank: 8
PRFX Calmar Ratio Rank: 4
PRFX Martin Ratio Rank: 7

FNDX

FNDX Risk / Return Rank: 75
FNDX Sharpe Ratio Rank: 73
FNDX Sortino Ratio Rank: 75
FNDX Omega Ratio Rank: 77
FNDX Calmar Ratio Rank: 71
FNDX Martin Ratio Rank: 81

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PRFX vs. FNDX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for PainReform Ltd. (PRFX) and Schwab Fundamental U.S. Large Company Index ETF (FNDX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PRFX	FNDX	Difference
Sharpe ratio Return per unit of total volatility	-0.67	1.24	-1.91
Sortino ratio Return per unit of downside risk	-1.58	1.80	-3.38
Omega ratio Gain probability vs. loss probability	0.83	1.28	-0.45
Calmar ratio Return relative to maximum drawdown	-0.96	1.73	-2.69
Martin ratio Return relative to average drawdown	-1.57	8.31	-9.88
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PRFX vs. FNDX - Sharpe Ratio Comparison

The current PRFX Sharpe Ratio is -0.67, which is lower than the FNDX Sharpe Ratio of 1.24. The chart below compares the historical Sharpe Ratios of PRFX and FNDX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PRFX	FNDX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.67	1.24	-1.91
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	0.79	-1.08
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.76	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.30	0.74	-1.04

Correlation

The correlation between PRFX and FNDX is 0.19, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PRFX vs. FNDX - Dividend Comparison

PRFX has not paid dividends to shareholders, while FNDX's dividend yield for the trailing twelve months is around 1.62%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PRFX PainReform Ltd.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
FNDX Schwab Fundamental U.S. Large Company Index ETF	1.62%	1.63%	1.76%	1.82%	2.07%	1.64%	2.29%	2.23%	2.40%	1.86%	2.01%	2.01%

Drawdowns

PRFX vs. FNDX - Drawdown Comparison

The maximum PRFX drawdown since its inception was -99.98%, which is greater than FNDX's maximum drawdown of -37.72%. Use the drawdown chart below to compare losses from any high point for PRFX and FNDX.

Drawdown Indicators

	PRFX	FNDX	Difference
Max Drawdown Largest peak-to-trough decline	-99.98%	-37.72%	-62.26%
Max Drawdown (1Y) Largest decline over 1 year	-84.51%	-12.25%	-72.26%
Max Drawdown (5Y) Largest decline over 5 years	-99.97%	-19.06%	-80.91%
Max Drawdown (10Y) Largest decline over 10 years	—	-37.72%	—
Current Drawdown Current decline from peak	-99.98%	-4.21%	-95.77%
Average Drawdown Average peak-to-trough decline	-83.25%	-3.59%	-79.66%
Ulcer Index Depth and duration of drawdowns from previous peaks	51.86%	2.55%	+49.31%

Volatility

PRFX vs. FNDX - Volatility Comparison

PainReform Ltd. (PRFX) has a higher volatility of 23.14% compared to Schwab Fundamental U.S. Large Company Index ETF (FNDX) at 3.93%. This indicates that PRFX's price experiences larger fluctuations and is considered to be riskier than FNDX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRFX	FNDX	Difference
Volatility (1M) Calculated over the trailing 1-month period	23.14%	3.93%	+19.21%
Volatility (6M) Calculated over the trailing 6-month period	70.74%	8.05%	+62.69%
Volatility (1Y) Calculated over the trailing 1-year period	120.83%	16.21%	+104.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	272.84%	15.26%	+257.58%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	259.87%	17.51%	+242.36%