PEN vs. MEDP

Last updated Jun 3, 2026

PEN (Penumbra, Inc.) and MEDP (Medpace Holdings, Inc.) are both stocks. Both are in the Healthcare sector — PEN in Medical Devices, MEDP in Diagnostics & Research. Over the past 5 years, PEN returned 4.43%/yr vs 21.44%/yr for MEDP. At a 0.32 correlation, their price movements are largely independent.

Performance

PEN vs. MEDP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Penumbra, Inc. (PEN) and Medpace Holdings, Inc. (MEDP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PEN achieves a 2.52% return, which is significantly higher than MEDP's -20.66% return.

PEN

• 1D: -0.07%
• 1M: -2.03%
• YTD: 2.52%
• 6M: 10.79%
• 1Y: 24.43%
• 3Y*: -0.22%
• 5Y*: 4.43%
• 10Y*: 19.10%

MEDP

• 1D: -1.30%
• 1M: 6.72%
• YTD: -20.66%
• 6M: -23.66%
• 1Y: 49.62%
• 3Y*: 28.08%
• 5Y*: 21.44%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PEN vs. MEDP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PEN Penumbra, Inc.	2.52%	30.92%	-5.59%	13.07%	-22.57%	64.18%	6.53%	34.43%	29.86%	47.49%
MEDP Medpace Holdings, Inc.	-20.66%	69.05%	8.38%	44.31%	-2.40%	56.35%	65.60%	58.81%	45.97%	0.53%

Correlation

The correlation between PEN and MEDP is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.14
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (All Time) Calculated using the full available price history since Aug 12, 2016	0.32

The correlation between PEN and MEDP shifts across timeframes, from 0.14 (1 year) to 0.35 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap PEN : $12.60B MEDP : $12.91B
EPS PEN : $4.34 MEDP : $15.63
PE Ratio PEN : 73.37 MEDP : 28.50
PEG Ratio PEN : 0.11 MEDP : 0.86
PS Ratio PEN : 8.63 MEDP : 4.90
PB Ratio PEN : 8.55 MEDP : 21.57
Total Revenue (TTM) PEN : $1.45B MEDP : $2.68B
Gross Profit (TTM) PEN : $979.97M MEDP : $778.59M
EBITDA (TTM) PEN : $212.61M MEDP : $572.96M

Return for Risk

PEN vs. MEDP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PEN

PEN Risk / Return Rank: 64
PEN Sharpe Ratio Rank: 64
PEN Sortino Ratio Rank: 67
PEN Omega Ratio Rank: 67
PEN Calmar Ratio Rank: 59
PEN Martin Ratio Rank: 63

MEDP

MEDP Risk / Return Rank: 69
MEDP Sharpe Ratio Rank: 64
MEDP Sortino Ratio Rank: 70
MEDP Omega Ratio Rank: 78
MEDP Calmar Ratio Rank: 67
MEDP Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PEN vs. MEDP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Penumbra, Inc. (PEN) and Medpace Holdings, Inc. (MEDP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PEN	MEDP	Difference
Sharpe ratio Return per unit of total volatility	0.73	0.72	+0.01
Sortino ratio Return per unit of downside risk	1.64	1.74	-0.10
Omega ratio Gain probability vs. loss probability	1.21	1.30	-0.08
Calmar ratio Return relative to maximum drawdown	0.90	1.40	-0.49
Martin ratio Return relative to average drawdown	2.54	3.23	-0.69
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PEN vs. MEDP - Sharpe Ratio Comparison

The current PEN Sharpe Ratio is 0.73, which is comparable to the MEDP Sharpe Ratio of 0.72. The chart below compares the historical Sharpe Ratios of PEN and MEDP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PEN	MEDP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.73	0.72	+0.01
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.11	0.42	-0.31
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.46	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.50	0.66	-0.16

Drawdowns

PEN vs. MEDP - Drawdown Comparison

The maximum PEN drawdown since its inception was -62.64%, which is greater than MEDP's maximum drawdown of -42.87%. Use the drawdown chart below to compare losses from any high point for PEN and MEDP.

Drawdown Indicators

	PEN	MEDP	Difference
Max Drawdown Largest peak-to-trough decline	-62.64%	-42.87%	-19.77%
Max Drawdown (1Y) Largest decline over 1 year	-21.44%	-36.61%	+15.17%
Max Drawdown (3Y) Largest decline over 3 years	-52.44%	-39.38%	-13.06%
Max Drawdown (5Y) Largest decline over 5 years	-60.14%	-42.87%	-17.27%
Max Drawdown (10Y) Largest decline over 10 years	-62.64%	—	—
Current Drawdown Current decline from peak	-11.31%	-28.20%	+16.89%
Average Drawdown Average peak-to-trough decline	-17.59%	-12.89%	-4.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.63%	15.83%	-8.20%

Volatility

PEN vs. MEDP - Volatility Comparison

The current volatility for Penumbra, Inc. (PEN) is 3.02%, while Medpace Holdings, Inc. (MEDP) has a volatility of 6.99%. This indicates that PEN experiences smaller price fluctuations and is considered to be less risky than MEDP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PEN	MEDP	Difference
Volatility (1M) Calculated over the trailing 1-month period	3.02%	6.99%	-3.97%
Volatility (6M) Calculated over the trailing 6-month period	17.73%	38.11%	-20.38%
Volatility (1Y) Calculated over the trailing 1-year period	33.87%	69.32%	-35.45%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	41.18%	51.61%	-10.43%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	41.49%	49.83%	-8.34%

Dividends

PEN vs. MEDP - Dividend Comparison

Neither PEN nor MEDP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

PEN vs. MEDP - Profitability Comparison

The chart below illustrates the profitability comparison between Penumbra, Inc. and Medpace Holdings, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

PEN - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Penumbra, Inc. reported a gross profit of 253.41M and revenue of 374.76M. Therefore, the gross margin over that period was 67.6%.

MEDP - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Medpace Holdings, Inc. reported a gross profit of 196.33M and revenue of 706.60M. Therefore, the gross margin over that period was 27.8%.

PEN - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Penumbra, Inc. reported an operating income of 38.23M and revenue of 374.76M, resulting in an operating margin of 10.2%.

MEDP - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Medpace Holdings, Inc. reported an operating income of 141.50M and revenue of 706.60M, resulting in an operating margin of 20.0%.

PEN - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Penumbra, Inc. reported a net income of 32.58M and revenue of 374.76M, resulting in a net margin of 8.7%.

MEDP - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Medpace Holdings, Inc. reported a net income of 123.87M and revenue of 706.60M, resulting in a net margin of 17.5%.

Frequently Asked Questions

Can I hold both PEN and MEDP in my portfolio?

PEN and MEDP have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PEN or MEDP?

MEDP has higher volatility (6.99%) compared to PEN (3.02%). In terms of maximum drawdown, PEN dropped -62.64% vs MEDP's -42.87%.

Which has better risk-adjusted returns?

PEN currently has the higher Sharpe Ratio (0.73 vs 0.72), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.