PEN vs. MEDP

Last updated Apr 1, 2026

Compare and contrast key facts about Penumbra, Inc. (PEN) and Medpace Holdings, Inc. (MEDP).

Performance

PEN vs. MEDP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Penumbra, Inc. (PEN) and Medpace Holdings, Inc. (MEDP). The values are adjusted to include any dividend payments, if applicable.

PEN vs. MEDP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PEN Penumbra, Inc.	5.62%	30.92%	-5.59%	13.07%	-22.57%	64.18%	6.53%	34.43%	29.86%	47.49%
MEDP Medpace Holdings, Inc.	-14.50%	69.05%	8.38%	44.31%	-2.40%	56.35%	65.60%	58.81%	45.97%	0.53%

Fundamentals

Market Cap PEN : $12.94B MEDP : $13.91B
EPS PEN : $4.52 MEDP : $15.23
PE Ratio PEN : 72.65 MEDP : 31.52
PEG Ratio PEN : 0.11 MEDP : 0.95
PS Ratio PEN : 9.20 MEDP : 5.62
PB Ratio PEN : 9.06 MEDP : 30.30
Total Revenue (TTM) PEN : $1.40B MEDP : $2.53B
Gross Profit (TTM) PEN : $942.44M MEDP : $760.62M
EBITDA (TTM) PEN : $214.72M MEDP : $541.22M

Returns By Period

In the year-to-date period, PEN achieves a 5.62% return, which is significantly higher than MEDP's -14.50% return.

PEN

• 1D: 0.05%
• 1M: -4.65%
• YTD: 5.62%
• 6M: 29.63%
• 1Y: 22.80%
• 3Y*: 5.62%
• 5Y*: 3.66%
• 10Y*: 21.53%

MEDP

• 1D: 4.32%
• 1M: 6.29%
• YTD: -14.50%
• 6M: -6.61%
• 1Y: 57.60%
• 3Y*: 36.68%
• 5Y*: 23.13%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PEN vs. MEDP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PEN

PEN Risk / Return Rank: 63
PEN Sharpe Ratio Rank: 64
PEN Sortino Ratio Rank: 66
PEN Omega Ratio Rank: 63
PEN Calmar Ratio Rank: 62
PEN Martin Ratio Rank: 60

MEDP

MEDP Risk / Return Rank: 77
MEDP Sharpe Ratio Rank: 71
MEDP Sortino Ratio Rank: 82
MEDP Omega Ratio Rank: 82
MEDP Calmar Ratio Rank: 74
MEDP Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PEN vs. MEDP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Penumbra, Inc. (PEN) and Medpace Holdings, Inc. (MEDP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PEN	MEDP	Difference
Sharpe ratio Return per unit of total volatility	0.62	0.85	-0.24
Sortino ratio Return per unit of downside risk	1.39	2.18	-0.79
Omega ratio Gain probability vs. loss probability	1.17	1.30	-0.13
Calmar ratio Return relative to maximum drawdown	0.92	1.63	-0.71
Martin ratio Return relative to average drawdown	1.96	4.82	-2.86
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PEN vs. MEDP - Sharpe Ratio Comparison

The current PEN Sharpe Ratio is 0.62, which is comparable to the MEDP Sharpe Ratio of 0.85. The chart below compares the historical Sharpe Ratios of PEN and MEDP, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PEN	MEDP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.62	0.85	-0.24
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.09	0.46	-0.37
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.52	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.51	0.70	-0.18

Correlation

The correlation between PEN and MEDP is 0.32, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PEN vs. MEDP - Dividend Comparison

Neither PEN nor MEDP has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

PEN vs. MEDP - Drawdown Comparison

The maximum PEN drawdown since its inception was -62.64%, which is greater than MEDP's maximum drawdown of -42.87%. Use the drawdown chart below to compare losses from any high point for PEN and MEDP.

Drawdown Indicators

	PEN	MEDP	Difference
Max Drawdown Largest peak-to-trough decline	-62.64%	-42.87%	-19.77%
Max Drawdown (1Y) Largest decline over 1 year	-24.76%	-32.96%	+8.20%
Max Drawdown (5Y) Largest decline over 5 years	-62.64%	-42.87%	-19.77%
Max Drawdown (10Y) Largest decline over 10 years	-62.64%	—	—
Current Drawdown Current decline from peak	-8.63%	-22.62%	+13.99%
Average Drawdown Average peak-to-trough decline	-17.73%	-12.64%	-5.09%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.58%	11.14%	+0.44%

Volatility

PEN vs. MEDP - Volatility Comparison

The current volatility for Penumbra, Inc. (PEN) is 2.66%, while Medpace Holdings, Inc. (MEDP) has a volatility of 11.00%. This indicates that PEN experiences smaller price fluctuations and is considered to be less risky than MEDP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PEN	MEDP	Difference
Volatility (1M) Calculated over the trailing 1-month period	2.66%	11.00%	-8.34%
Volatility (6M) Calculated over the trailing 6-month period	26.57%	29.67%	-3.10%
Volatility (1Y) Calculated over the trailing 1-year period	37.10%	67.80%	-30.70%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	41.81%	50.92%	-9.11%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	41.77%	49.58%	-7.81%

Financials

PEN vs. MEDP - Profitability Comparison

The chart below illustrates the profitability comparison between Penumbra, Inc. and Medpace Holdings, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

PEN - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Penumbra, Inc. reported a gross profit of 262.13M and revenue of 385.39M. Therefore, the gross margin over that period was 68.0%.

MEDP - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Medpace Holdings, Inc. reported a gross profit of 205.32M and revenue of 708.45M. Therefore, the gross margin over that period was 29.0%.

PEN - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Penumbra, Inc. reported an operating income of 59.23M and revenue of 385.39M, resulting in an operating margin of 15.4%.

MEDP - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Medpace Holdings, Inc. reported an operating income of 153.27M and revenue of 708.45M, resulting in an operating margin of 21.6%.

PEN - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Penumbra, Inc. reported a net income of 47.34M and revenue of 385.39M, resulting in a net margin of 12.3%.

MEDP - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Medpace Holdings, Inc. reported a net income of 135.13M and revenue of 708.45M, resulting in a net margin of 19.1%.