PDSB vs. MSFRX

Last updated Jun 25, 2026

PDSB (PDS Biotechnology Corporation) is a stock, while MSFRX (MFS Total Return Fund) is Diversified Portfolio fund managed by MFS. Over the past 10 years, PDSB returned -41.43%/yr vs 8.12%/yr for MSFRX. At a 0.26 correlation, their price movements are largely independent.

Performance

PDSB vs. MSFRX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in PDS Biotechnology Corporation (PDSB) and MFS Total Return Fund (MSFRX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PDSB achieves a 13.51% return, which is significantly higher than MSFRX's 2.71% return. Over the past 10 years, PDSB has underperformed MSFRX with an annualized return of -41.43%, while MSFRX has yielded a comparatively higher 8.12% annualized return.

PDSB

• 1D: -4.19%
• 1M: -27.18%
• YTD: 13.51%
• 6M: -2.18%
• 1Y: -45.39%
• 3Y*: -45.67%
• 5Y*: -39.74%
• 10Y*: -41.43%

MSFRX

• 1D: 0.36%
• 1M: -0.05%
• YTD: 2.71%
• 6M: 2.21%
• 1Y: 9.54%
• 3Y*: 12.03%
• 5Y*: 6.46%
• 10Y*: 8.12%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PDSB vs. MSFRX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PDSB PDS Biotechnology Corporation	13.51%	-52.77%	-67.20%	-62.35%	62.96%	278.50%	-19.25%	-58.72%	-96.57%	-25.04%
MSFRX MFS Total Return Fund	2.71%	10.98%	14.73%	10.34%	-9.70%	14.00%	9.72%	20.20%	-5.80%	12.18%

Correlation

The correlation between PDSB and MSFRX is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.33
Correlation (10Y) Calculated over the trailing 10-year period	0.25
Correlation (All Time) Calculated using the full available price history since Oct 1, 2015	0.26

The correlation between PDSB and MSFRX shifts across timeframes, from 0.22 (1 year) to 0.33 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

PDSB vs. MSFRX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PDSB

PDSB Risk / Return Rank: 22
PDSB Sharpe Ratio Rank: 23
PDSB Sortino Ratio Rank: 28
PDSB Omega Ratio Rank: 28
PDSB Calmar Ratio Rank: 16
PDSB Martin Ratio Rank: 15

MSFRX

MSFRX Risk / Return Rank: 32
MSFRX Sharpe Ratio Rank: 32
MSFRX Sortino Ratio Rank: 35
MSFRX Omega Ratio Rank: 30
MSFRX Calmar Ratio Rank: 34
MSFRX Martin Ratio Rank: 28

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PDSB vs. MSFRX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for PDS Biotechnology Corporation (PDSB) and MFS Total Return Fund (MSFRX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PDSB	MSFRX	Difference
Sharpe ratio: Return per unit of total volatility	-0.46	1.48	-1.94
Sortino ratio: Return per unit of downside risk	-0.18	2.24	-2.41
Omega ratio: Gain probability vs. loss probability	0.98	1.26	-0.28
Calmar ratio: Return relative to maximum drawdown	-0.71	2.05	-2.75
Martin ratio: Return relative to average drawdown	-1.21	5.90	-7.11

PDSB vs. MSFRX - Sharpe Ratio Comparison

The current PDSB Sharpe Ratio is -0.46, which is lower than the MSFRX Sharpe Ratio of 1.48. The chart below compares the historical Sharpe Ratios of PDSB and MSFRX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PDSB vs. MSFRX - Drawdown Comparison

The maximum PDSB drawdown since its inception was -99.89%, which is greater than MSFRX's maximum drawdown of -37.28%. Use the drawdown chart below to compare losses from any high point for PDSB and MSFRX.

Drawdown Indicators

	PDSB	MSFRX	Difference
Max Drawdown Largest peak-to-trough decline	-99.89%	-37.28%	-62.61%
Max Drawdown (1Y) Largest decline over 1 year	-64.47%	-4.96%	-59.51%
Max Drawdown (3Y) Largest decline over 3 years	-91.86%	-8.56%	-83.30%
Max Drawdown (5Y) Largest decline over 5 years	-96.86%	-17.02%	-79.84%
Max Drawdown (10Y) Largest decline over 10 years	-99.85%	-24.70%	-75.15%
Current Drawdown Current decline from peak	-99.81%	-2.41%	-97.40%
Average Drawdown Average peak-to-trough decline	-88.20%	-5.00%	-83.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	40.61%	1.72%	+38.89%

Volatility

PDSB vs. MSFRX - Volatility Comparison

PDS Biotechnology Corporation (PDSB) has a higher volatility of 29.31% compared to MFS Total Return Fund (MSFRX) at 2.05%. This indicates that PDSB's price experiences larger fluctuations and is considered to be riskier than MSFRX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PDSB	MSFRX	Difference
Volatility (1M) Calculated over the trailing 1-month period	29.31%	2.05%	+27.26%
Volatility (6M) Calculated over the trailing 6-month period	85.00%	5.05%	+79.95%
Volatility (1Y) Calculated over the trailing 1-year period	99.60%	6.89%	+92.71%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	89.35%	9.75%	+79.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	101.47%	10.44%	+91.03%

Dividends

PDSB vs. MSFRX - Dividend Comparison

PDSB has not paid dividends to shareholders, while MSFRX's dividend yield for the trailing twelve months is around 8.82%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
MSFRX MFS Total Return Fund	8.82%	8.93%	14.87%	6.19%	5.38%	8.33%	6.93%	3.22%	4.99%	5.67%	3.54%	5.55%
PDSB PDS Biotechnology Corporation	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both PDSB and MSFRX in my portfolio?

PDSB and MSFRX have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PDSB or MSFRX?

PDSB has higher volatility (29.31%) compared to MSFRX (2.05%). In terms of maximum drawdown, PDSB dropped -99.89% vs MSFRX's -37.28%.

Which has better risk-adjusted returns?

MSFRX currently has the higher Sharpe Ratio (1.48 vs -0.46), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.