PCVX vs. ZS

Last updated Jun 6, 2026

PCVX (Vaxcyte, Inc.) and ZS (Zscaler, Inc.) are both stocks. PCVX operates in Biotechnology (Healthcare), while ZS operates in Software - Infrastructure (Technology). Over the past 5 years, PCVX returned 16.69%/yr vs -6.78%/yr for ZS. At a 0.21 correlation, their price movements are largely independent.

Performance

PCVX vs. ZS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vaxcyte, Inc. (PCVX) and Zscaler, Inc. (ZS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PCVX achieves a 2.64% return, which is significantly higher than ZS's -41.85% return.

PCVX

• 1D: -2.87%
• 1M: -8.00%
• YTD: 2.64%
• 6M: 1.89%
• 1Y: 28.03%
• 3Y*: -3.00%
• 5Y*: 16.69%
• 10Y*: —

ZS

• 1D: -3.31%
• 1M: -14.41%
• YTD: -41.85%
• 6M: -46.11%
• 1Y: -56.84%
• 3Y*: -5.09%
• 5Y*: -6.78%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PCVX vs. ZS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
PCVX Vaxcyte, Inc.	2.64%	-43.64%	30.35%	30.97%	101.56%	-10.46%	1.61%
ZS Zscaler, Inc.	-41.85%	24.67%	-18.57%	98.00%	-65.18%	60.90%	94.90%

Correlation

The correlation between PCVX and ZS is 0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.07
Correlation (3Y) Calculated over the trailing 3-year period	0.18
Correlation (5Y) Calculated over the trailing 5-year period	0.22
Correlation (All Time) Calculated using the full available price history since Jun 15, 2020	0.21

The correlation between PCVX and ZS shifts across timeframes, from 0.07 (1 year) to 0.22 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap PCVX : $6.61B ZS : $21.02B
EPS PCVX : -$6.91 ZS : -$0.49
PB Ratio PCVX : 2.21 ZS : 8.88
Total Revenue (TTM) PCVX : $0.00 ZS : $3.17B
Gross Profit (TTM) PCVX : $0.00 ZS : $2.43B
EBITDA (TTM) PCVX : -$951.77M ZS : $69.08M

Return for Risk

PCVX vs. ZS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PCVX

PCVX Risk / Return Rank: 65
PCVX Sharpe Ratio Rank: 67
PCVX Sortino Ratio Rank: 63
PCVX Omega Ratio Rank: 59
PCVX Calmar Ratio Rank: 68
PCVX Martin Ratio Rank: 69

ZS

ZS Risk / Return Rank: 6
ZS Sharpe Ratio Rank: 5
ZS Sortino Ratio Rank: 8
ZS Omega Ratio Rank: 5
ZS Calmar Ratio Rank: 8
ZS Martin Ratio Rank: 4

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PCVX vs. ZS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vaxcyte, Inc. (PCVX) and Zscaler, Inc. (ZS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PCVX	ZS	Difference
Sharpe ratio: Return per unit of total volatility	0.78	-0.97	+1.75
Sortino ratio: Return per unit of downside risk	1.36	-1.32	+2.68
Omega ratio: Gain probability vs. loss probability	1.16	0.79	+0.37
Calmar ratio: Return relative to maximum drawdown	1.42	-0.87	+2.29
Martin ratio: Return relative to average drawdown	3.47	-1.58	+5.05
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PCVX vs. ZS - Sharpe Ratio Comparison

The current PCVX Sharpe Ratio is 0.78, which is higher than the ZS Sharpe Ratio of -0.97. The chart below compares the historical Sharpe Ratios of PCVX and ZS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PCVX	ZS	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.78	-0.97	+1.75
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.26	-0.12	+0.39
Sharpe Ratio (All Time) Calculated using the full available price history	0.16	0.31	-0.15

Drawdowns

PCVX vs. ZS - Drawdown Comparison

The maximum PCVX drawdown since its inception was -76.22%, roughly equal to the maximum ZS drawdown of -76.41%. Use the drawdown chart below to compare losses from any high point for PCVX and ZS.

Drawdown Indicators

	PCVX	ZS	Difference
Max Drawdown Largest peak-to-trough decline	-76.22%	-76.41%	+0.19%
Max Drawdown (1Y) Largest decline over 1 year	-25.56%	-64.89%	+39.33%
Max Drawdown (3Y) Largest decline over 3 years	-76.22%	-64.89%	-11.33%
Max Drawdown (5Y) Largest decline over 5 years	-76.22%	-76.41%	+0.19%
Current Drawdown Current decline from peak	-59.84%	-64.54%	+4.70%
Average Drawdown Average peak-to-trough decline	-38.09%	-32.61%	-5.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.43%	35.84%	-25.41%

Volatility

PCVX vs. ZS - Volatility Comparison

The current volatility for Vaxcyte, Inc. (PCVX) is 17.09%, while Zscaler, Inc. (ZS) has a volatility of 45.63%. This indicates that PCVX experiences smaller price fluctuations and is considered to be less risky than ZS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PCVX	ZS	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.09%	45.63%	-28.54%
Volatility (6M) Calculated over the trailing 6-month period	31.69%	57.30%	-25.61%
Volatility (1Y) Calculated over the trailing 1-year period	46.44%	58.63%	-12.19%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	63.51%	56.10%	+7.41%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	66.10%	58.44%	+7.66%

Dividends

PCVX vs. ZS - Dividend Comparison

Neither PCVX nor ZS has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PCVX and ZS in my portfolio?

PCVX and ZS have a correlation of 0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PCVX or ZS?

ZS has higher volatility (45.63%) compared to PCVX (17.09%). In terms of maximum drawdown, PCVX dropped -76.22% vs ZS's -76.41%.

Which has better risk-adjusted returns?

PCVX currently has the higher Sharpe Ratio (0.78 vs -0.97), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.