OSIS vs. LNTH

Last updated Apr 1, 2026

Compare and contrast key facts about OSI Systems, Inc. (OSIS) and Lantheus Holdings, Inc. (LNTH).

Performance

OSIS vs. LNTH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in OSI Systems, Inc. (OSIS) and Lantheus Holdings, Inc. (LNTH). The values are adjusted to include any dividend payments, if applicable.

OSIS vs. LNTH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
OSIS OSI Systems, Inc.	4.10%	52.34%	29.74%	62.29%	-14.68%	-0.02%	-7.46%	37.44%	13.86%	-15.42%
LNTH Lantheus Holdings, Inc.	13.97%	-25.61%	44.29%	21.66%	76.39%	114.16%	-34.23%	31.05%	-23.47%	137.79%

Fundamentals

Market Cap OSIS : $4.64B LNTH : $5.03B
EPS OSIS : $8.78 LNTH : $3.43
PE Ratio OSIS : 30.26 LNTH : 22.11
PEG Ratio OSIS : 1.22 LNTH : 0.09
PS Ratio OSIS : 2.58 LNTH : 3.35
PB Ratio OSIS : 5.49 LNTH : 4.62
Total Revenue (TTM) OSIS : $1.80B LNTH : $1.54B
Gross Profit (TTM) OSIS : $593.34M LNTH : $941.95M
EBITDA (TTM) OSIS : $252.85M LNTH : $382.55M

Returns By Period

In the year-to-date period, OSIS achieves a 4.10% return, which is significantly lower than LNTH's 13.97% return. Over the past 10 years, OSIS has underperformed LNTH with an annualized return of 14.97%, while LNTH has yielded a comparatively higher 44.66% annualized return.

OSIS

• 1D: 0.30%
• 1M: -6.90%
• YTD: 4.10%
• 6M: 6.53%
• 1Y: 36.62%
• 3Y*: 37.40%
• 5Y*: 22.33%
• 10Y*: 14.97%

LNTH

• 1D: 3.78%
• 1M: 1.25%
• YTD: 13.97%
• 6M: 47.88%
• 1Y: -22.28%
• 3Y*: -2.79%
• 5Y*: 29.28%
• 10Y*: 44.66%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

OSIS vs. LNTH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OSIS

OSIS Risk / Return Rank: 73
OSIS Sharpe Ratio Rank: 71
OSIS Sortino Ratio Rank: 69
OSIS Omega Ratio Rank: 65
OSIS Calmar Ratio Rank: 78
OSIS Martin Ratio Rank: 81

LNTH

LNTH Risk / Return Rank: 27
LNTH Sharpe Ratio Rank: 23
LNTH Sortino Ratio Rank: 25
LNTH Omega Ratio Rank: 24
LNTH Calmar Ratio Rank: 30
LNTH Martin Ratio Rank: 33

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OSIS vs. LNTH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for OSI Systems, Inc. (OSIS) and Lantheus Holdings, Inc. (LNTH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OSIS	LNTH	Difference
Sharpe ratio Return per unit of total volatility	0.88	-0.43	+1.30
Sortino ratio Return per unit of downside risk	1.50	-0.23	+1.73
Omega ratio Gain probability vs. loss probability	1.19	0.96	+0.23
Calmar ratio Return relative to maximum drawdown	2.02	-0.39	+2.41
Martin ratio Return relative to average drawdown	6.15	-0.56	+6.71
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OSIS vs. LNTH - Sharpe Ratio Comparison

The current OSIS Sharpe Ratio is 0.88, which is higher than the LNTH Sharpe Ratio of -0.43. The chart below compares the historical Sharpe Ratios of OSIS and LNTH, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	OSIS	LNTH	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.88	-0.43	+1.30
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.71	0.51	+0.19
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.45	0.72	-0.27
Sharpe Ratio (All Time) Calculated using the full available price history	0.17	0.39	-0.21

Correlation

The correlation between OSIS and LNTH is 0.28, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

OSIS vs. LNTH - Dividend Comparison

Neither OSIS nor LNTH has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

OSIS vs. LNTH - Drawdown Comparison

The maximum OSIS drawdown since its inception was -88.44%, which is greater than LNTH's maximum drawdown of -78.62%. Use the drawdown chart below to compare losses from any high point for OSIS and LNTH.

Drawdown Indicators

	OSIS	LNTH	Difference
Max Drawdown Largest peak-to-trough decline	-88.44%	-78.62%	-9.82%
Max Drawdown (1Y) Largest decline over 1 year	-18.47%	-53.92%	+35.45%
Max Drawdown (5Y) Largest decline over 5 years	-30.66%	-59.46%	+28.80%
Max Drawdown (10Y) Largest decline over 10 years	-53.64%	-68.52%	+14.88%
Current Drawdown Current decline from peak	-10.86%	-38.64%	+27.78%
Average Drawdown Average peak-to-trough decline	-25.74%	-28.22%	+2.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.07%	37.92%	-31.85%

Volatility

OSIS vs. LNTH - Volatility Comparison

The current volatility for OSI Systems, Inc. (OSIS) is 13.59%, while Lantheus Holdings, Inc. (LNTH) has a volatility of 15.01%. This indicates that OSIS experiences smaller price fluctuations and is considered to be less risky than LNTH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OSIS	LNTH	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.59%	15.01%	-1.42%
Volatility (6M) Calculated over the trailing 6-month period	31.64%	25.31%	+6.33%
Volatility (1Y) Calculated over the trailing 1-year period	41.99%	52.54%	-10.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	31.77%	57.33%	-25.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.37%	62.10%	-28.73%

Financials

OSIS vs. LNTH - Profitability Comparison

The chart below illustrates the profitability comparison between OSI Systems, Inc. and Lantheus Holdings, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

OSIS - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, OSI Systems, Inc. reported a gross profit of 151.63M and revenue of 464.06M. Therefore, the gross margin over that period was 32.7%.

LNTH - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Lantheus Holdings, Inc. reported a gross profit of 240.88M and revenue of 406.79M. Therefore, the gross margin over that period was 59.2%.

OSIS - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, OSI Systems, Inc. reported an operating income of 58.80M and revenue of 464.06M, resulting in an operating margin of 12.7%.

LNTH - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Lantheus Holdings, Inc. reported an operating income of 77.18M and revenue of 406.79M, resulting in an operating margin of 19.0%.

OSIS - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, OSI Systems, Inc. reported a net income of 38.70M and revenue of 464.06M, resulting in a net margin of 8.3%.

LNTH - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Lantheus Holdings, Inc. reported a net income of 54.09M and revenue of 406.79M, resulting in a net margin of 13.3%.