NWBO vs. ARDX

Last updated Apr 1, 2026

Compare and contrast key facts about Northwest Biotherapeutics, Inc. (NWBO) and Ardelyx, Inc. (ARDX).

Performance

NWBO vs. ARDX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Northwest Biotherapeutics, Inc. (NWBO) and Ardelyx, Inc. (ARDX). The values are adjusted to include any dividend payments, if applicable.

NWBO vs. ARDX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
NWBO Northwest Biotherapeutics, Inc.	-9.73%	-16.74%	-60.81%	-10.64%	12.07%	-54.10%	626.19%	2.19%	-14.38%	-31.05%
ARDX Ardelyx, Inc.	2.74%	14.99%	-18.23%	117.54%	159.09%	-83.00%	-13.79%	319.27%	-72.88%	-53.52%

Fundamentals

Market Cap NWBO : $308.11M ARDX : $1.46B
EPS NWBO : -$0.06 ARDX : -$0.25
PS Ratio NWBO : 322.89 ARDX : 3.56
Total Revenue (TTM) NWBO : $937.00K ARDX : $407.32M
Gross Profit (TTM) NWBO : $737.00K ARDX : $367.78M
EBITDA (TTM) NWBO : -$79.62M ARDX : -$33.44M

Returns By Period

In the year-to-date period, NWBO achieves a -9.73% return, which is significantly lower than ARDX's 2.74% return. Over the past 10 years, NWBO has underperformed ARDX with an annualized return of -18.04%, while ARDX has yielded a comparatively higher -2.58% annualized return.

NWBO

• 1D: 4.56%
• 1M: -8.59%
• YTD: -9.73%
• 6M: -14.03%
• 1Y: -9.59%
• 3Y*: -30.87%
• 5Y*: -31.76%
• 10Y*: -18.04%

ARDX

• 1D: 7.93%
• 1M: -8.55%
• YTD: 2.74%
• 6M: 8.71%
• 1Y: 22.00%
• 3Y*: 7.74%
• 5Y*: -2.68%
• 10Y*: -2.58%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

NWBO vs. ARDX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NWBO

NWBO Risk / Return Rank: 40
NWBO Sharpe Ratio Rank: 36
NWBO Sortino Ratio Rank: 46
NWBO Omega Ratio Rank: 46
NWBO Calmar Ratio Rank: 34
NWBO Martin Ratio Rank: 37

ARDX

ARDX Risk / Return Rank: 55
ARDX Sharpe Ratio Rank: 54
ARDX Sortino Ratio Rank: 56
ARDX Omega Ratio Rank: 56
ARDX Calmar Ratio Rank: 55
ARDX Martin Ratio Rank: 54

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NWBO vs. ARDX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Northwest Biotherapeutics, Inc. (NWBO) and Ardelyx, Inc. (ARDX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	NWBO	ARDX	Difference
Sharpe ratio Return per unit of total volatility	-0.10	0.32	-0.41
Sortino ratio Return per unit of downside risk	0.63	0.99	-0.36
Omega ratio Gain probability vs. loss probability	1.09	1.13	-0.05
Calmar ratio Return relative to maximum drawdown	-0.22	0.53	-0.75
Martin ratio Return relative to average drawdown	-0.29	1.11	-1.39
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

NWBO vs. ARDX - Sharpe Ratio Comparison

The current NWBO Sharpe Ratio is -0.10, which is lower than the ARDX Sharpe Ratio of 0.32. The chart below compares the historical Sharpe Ratios of NWBO and ARDX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	NWBO	ARDX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.10	0.32	-0.41
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.39	-0.03	-0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.19	-0.03	-0.16
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	-0.08	-0.09

Correlation

The correlation between NWBO and ARDX is 0.12, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

NWBO vs. ARDX - Dividend Comparison

Neither NWBO nor ARDX has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

NWBO vs. ARDX - Drawdown Comparison

The maximum NWBO drawdown since its inception was -99.99%, roughly equal to the maximum ARDX drawdown of -98.45%. Use the drawdown chart below to compare losses from any high point for NWBO and ARDX.

Drawdown Indicators

	NWBO	ARDX	Difference
Max Drawdown Largest peak-to-trough decline	-99.99%	-98.45%	-1.54%
Max Drawdown (1Y) Largest decline over 1 year	-54.89%	-40.42%	-14.47%
Max Drawdown (5Y) Largest decline over 5 years	-90.49%	-94.32%	+3.83%
Max Drawdown (10Y) Largest decline over 10 years	-91.93%	-96.82%	+4.89%
Current Drawdown Current decline from peak	-99.98%	-81.79%	-18.19%
Average Drawdown Average peak-to-trough decline	-97.14%	-77.32%	-19.82%
Ulcer Index Depth and duration of drawdowns from previous peaks	41.40%	19.44%	+21.96%

Volatility

NWBO vs. ARDX - Volatility Comparison

The current volatility for Northwest Biotherapeutics, Inc. (NWBO) is 15.46%, while Ardelyx, Inc. (ARDX) has a volatility of 17.06%. This indicates that NWBO experiences smaller price fluctuations and is considered to be less risky than ARDX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NWBO	ARDX	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.46%	17.06%	-1.60%
Volatility (6M) Calculated over the trailing 6-month period	50.02%	50.12%	-0.10%
Volatility (1Y) Calculated over the trailing 1-year period	98.47%	69.85%	+28.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	82.30%	89.98%	-7.68%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	93.58%	84.27%	+9.31%

Financials