NVO vs. VXUS

Last updated Jun 20, 2026

NVO (Novo Nordisk A/S) is a stock, while VXUS (Vanguard Total International Stock ETF) is Global Equities fund tracking the FTSE Global All Cap ex US Index. Over the past 10 years, NVO returned 7.50%/yr vs 10.00%/yr for VXUS. At a 0.41 correlation, their price movements are largely independent.

Performance

NVO vs. VXUS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Novo Nordisk A/S (NVO) and Vanguard Total International Stock ETF (VXUS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, NVO achieves a -12.15% return, which is significantly lower than VXUS's 15.66% return. Over the past 10 years, NVO has underperformed VXUS with an annualized return of 7.50%, while VXUS has yielded a comparatively higher 10.00% annualized return.

NVO

• 1D: -0.76%
• 1M: -3.94%
• YTD: -12.15%
• 6M: -7.05%
• 1Y: -38.72%
• 3Y*: -16.67%
• 5Y*: 3.13%
• 10Y*: 7.50%

VXUS

• 1D: 1.17%
• 1M: 3.20%
• YTD: 15.66%
• 6M: 16.85%
• 1Y: 34.05%
• 3Y*: 18.62%
• 5Y*: 9.33%
• 10Y*: 10.00%

*Multi-year figures are annualized to reflect compound growth (CAGR)

NVO vs. VXUS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
NVO Novo Nordisk A/S	-12.15%	-39.22%	-15.93%	54.84%	22.66%	63.52%	23.33%	28.70%	-12.98%	52.92%
VXUS Vanguard Total International Stock ETF	15.66%	32.35%	5.08%	15.86%	-16.08%	8.98%	10.66%	21.75%	-14.43%	27.46%

Correlation

The correlation between NVO and VXUS is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.33
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (10Y) Calculated over the trailing 10-year period	0.36
Correlation (All Time) Calculated using the full available price history since Jan 28, 2011	0.41

Return for Risk

NVO vs. VXUS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NVO

NVO Risk / Return Rank: 13
NVO Sharpe Ratio Rank: 10
NVO Sortino Ratio Rank: 14
NVO Omega Ratio Rank: 12
NVO Calmar Ratio Rank: 13
NVO Martin Ratio Rank: 15

VXUS

VXUS Risk / Return Rank: 65
VXUS Sharpe Ratio Rank: 66
VXUS Sortino Ratio Rank: 63
VXUS Omega Ratio Rank: 67
VXUS Calmar Ratio Rank: 62
VXUS Martin Ratio Rank: 65

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NVO vs. VXUS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Novo Nordisk A/S (NVO) and Vanguard Total International Stock ETF (VXUS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	NVO	VXUS	Difference
Sharpe ratio: Return per unit of total volatility	-0.76	2.06	-2.82
Sortino ratio: Return per unit of downside risk	-0.87	2.81	-3.68
Omega ratio: Gain probability vs. loss probability	0.87	1.38	-0.51
Calmar ratio: Return relative to maximum drawdown	-0.77	2.94	-3.71
Martin ratio: Return relative to average drawdown	-1.20	11.32	-12.52

NVO vs. VXUS - Sharpe Ratio Comparison

The current NVO Sharpe Ratio is -0.76, which is lower than the VXUS Sharpe Ratio of 2.06. The chart below compares the historical Sharpe Ratios of NVO and VXUS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

NVO vs. VXUS - Drawdown Comparison

The maximum NVO drawdown since its inception was -74.70%, which is greater than VXUS's maximum drawdown of -35.97%. Use the drawdown chart below to compare losses from any high point for NVO and VXUS.

Drawdown Indicators

	NVO	VXUS	Difference
Max Drawdown Largest peak-to-trough decline	-74.70%	-35.97%	-38.73%
Max Drawdown (1Y) Largest decline over 1 year	-50.59%	-11.27%	-39.32%
Max Drawdown (3Y) Largest decline over 3 years	-74.70%	-13.58%	-61.12%
Max Drawdown (5Y) Largest decline over 5 years	-74.70%	-29.44%	-45.26%
Max Drawdown (10Y) Largest decline over 10 years	-74.70%	-35.97%	-38.73%
Current Drawdown Current decline from peak	-68.62%	0.00%	-68.62%
Average Drawdown Average peak-to-trough decline	-17.81%	-8.20%	-9.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	32.66%	2.92%	+29.74%

Volatility

NVO vs. VXUS - Volatility Comparison

Novo Nordisk A/S (NVO) has a higher volatility of 10.13% compared to Vanguard Total International Stock ETF (VXUS) at 6.45%. This indicates that NVO's price experiences larger fluctuations and is considered to be riskier than VXUS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NVO	VXUS	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.13%	6.45%	+3.68%
Volatility (6M) Calculated over the trailing 6-month period	37.86%	14.12%	+23.74%
Volatility (1Y) Calculated over the trailing 1-year period	51.56%	16.07%	+35.49%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	38.34%	16.22%	+22.12%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.53%	17.20%	+15.33%

Dividends

NVO vs. VXUS - Dividend Comparison

NVO's dividend yield for the trailing twelve months is around 4.17%, more than VXUS's 3.08% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
NVO Novo Nordisk A/S	4.17%	3.31%	1.68%	1.00%	1.20%	1.35%	1.87%	2.14%	1.45%	1.52%	2.87%	0.92%
VXUS Vanguard Total International Stock ETF	2.52%	3.18%	3.37%	3.24%	3.09%	3.10%	2.14%	3.06%	3.18%	2.73%	2.93%	2.83%

Frequently Asked Questions

Can I hold both NVO and VXUS in my portfolio?

NVO and VXUS have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, NVO or VXUS?

NVO has higher volatility (10.13%) compared to VXUS (6.45%). In terms of maximum drawdown, NVO dropped -74.70% vs VXUS's -35.97%.

Which has better risk-adjusted returns?

VXUS currently has the higher Sharpe Ratio (2.06 vs -0.76), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.