MLTX vs. SMCI

Last updated Apr 1, 2026

Compare and contrast key facts about MoonLake Immunotherapeutics (MLTX) and Super Micro Computer, Inc. (SMCI).

Performance

MLTX vs. SMCI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in MoonLake Immunotherapeutics (MLTX) and Super Micro Computer, Inc. (SMCI). The values are adjusted to include any dividend payments, if applicable.

MLTX vs. SMCI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
MLTX MoonLake Immunotherapeutics	41.43%	-75.66%	-10.33%	475.14%	6.17%	-13.02%	8.39%
SMCI Super Micro Computer, Inc.	-22.21%	-3.97%	7.23%	246.24%	86.80%	38.82%	19.40%

Fundamentals

Market Cap MLTX : $1.20B SMCI : $15.35B
EPS MLTX : -$3.60 SMCI : $1.33
PB Ratio MLTX : 3.95 SMCI : 2.20
Total Revenue (TTM) MLTX : $0.00 SMCI : $28.06B
Gross Profit (TTM) MLTX : -$1.49M SMCI : $2.25B
EBITDA (TTM) MLTX : -$219.85M SMCI : $782.10M

Returns By Period

In the year-to-date period, MLTX achieves a 41.43% return, which is significantly higher than SMCI's -22.21% return.

MLTX

• 1D: 10.10%
• 1M: 6.45%
• YTD: 41.43%
• 6M: 159.97%
• 1Y: -52.29%
• 3Y*: -4.48%
• 5Y*: 12.68%
• 10Y*: —

SMCI

• 1D: 8.12%
• 1M: -29.70%
• YTD: -22.21%
• 6M: -52.50%
• 1Y: -33.50%
• 3Y*: 28.81%
• 5Y*: 41.89%
• 10Y*: 20.77%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

MLTX vs. SMCI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MLTX

MLTX Risk / Return Rank: 39
MLTX Sharpe Ratio Rank: 21
MLTX Sortino Ratio Rank: 54
MLTX Omega Ratio Rank: 73
MLTX Calmar Ratio Rank: 22
MLTX Martin Ratio Rank: 25

SMCI

SMCI Risk / Return Rank: 26
SMCI Sharpe Ratio Rank: 23
SMCI Sortino Ratio Rank: 28
SMCI Omega Ratio Rank: 27
SMCI Calmar Ratio Rank: 26
SMCI Martin Ratio Rank: 24

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MLTX vs. SMCI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for MoonLake Immunotherapeutics (MLTX) and Super Micro Computer, Inc. (SMCI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MLTX	SMCI	Difference
Sharpe ratio Return per unit of total volatility	-0.45	-0.42	-0.03
Sortino ratio Return per unit of downside risk	0.95	-0.14	+1.08
Omega ratio Gain probability vs. loss probability	1.24	0.98	+0.25
Calmar ratio Return relative to maximum drawdown	-0.59	-0.51	-0.09
Martin ratio Return relative to average drawdown	-0.96	-1.02	+0.05
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MLTX vs. SMCI - Sharpe Ratio Comparison

The current MLTX Sharpe Ratio is -0.45, which is comparable to the SMCI Sharpe Ratio of -0.42. The chart below compares the historical Sharpe Ratios of MLTX and SMCI, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	MLTX	SMCI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.45	-0.42	-0.03
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.14	0.50	-0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.30	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.13	0.30	-0.17

Correlation

The correlation between MLTX and SMCI is 0.11, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

MLTX vs. SMCI - Dividend Comparison

Neither MLTX nor SMCI has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

MLTX vs. SMCI - Drawdown Comparison

The maximum MLTX drawdown since its inception was -90.22%, which is greater than SMCI's maximum drawdown of -84.84%. Use the drawdown chart below to compare losses from any high point for MLTX and SMCI.

Drawdown Indicators

	MLTX	SMCI	Difference
Max Drawdown Largest peak-to-trough decline	-90.22%	-84.84%	-5.38%
Max Drawdown (1Y) Largest decline over 1 year	-89.93%	-66.18%	-23.75%
Max Drawdown (5Y) Largest decline over 5 years	-90.22%	-84.84%	-5.38%
Max Drawdown (10Y) Largest decline over 10 years	—	-84.84%	—
Current Drawdown Current decline from peak	-70.81%	-80.83%	+10.02%
Average Drawdown Average peak-to-trough decline	-27.76%	-31.55%	+3.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	55.33%	33.00%	+22.33%

Volatility

MLTX vs. SMCI - Volatility Comparison

The current volatility for MoonLake Immunotherapeutics (MLTX) is 15.99%, while Super Micro Computer, Inc. (SMCI) has a volatility of 45.06%. This indicates that MLTX experiences smaller price fluctuations and is considered to be less risky than SMCI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MLTX	SMCI	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.99%	45.06%	-29.07%
Volatility (6M) Calculated over the trailing 6-month period	57.65%	62.48%	-4.83%
Volatility (1Y) Calculated over the trailing 1-year period	116.38%	79.48%	+36.90%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	90.31%	83.60%	+6.71%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	87.08%	69.70%	+17.38%

Financials