MLTX vs. ^GSPC

Last updated Apr 2, 2026

Compare and contrast key facts about MoonLake Immunotherapeutics (MLTX) and S&P 500 Index (^GSPC).

Performance

MLTX vs. ^GSPC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in MoonLake Immunotherapeutics (MLTX) and S&P 500 Index (^GSPC). The values are adjusted to include any dividend payments, if applicable.

MLTX vs. ^GSPC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
MLTX MoonLake Immunotherapeutics	25.34%	-75.66%	-10.33%	475.14%	6.17%	-13.02%	8.39%
^GSPC S&P 500 Index	-3.95%	16.39%	23.31%	24.23%	-19.44%	26.89%	9.09%

Returns By Period

In the year-to-date period, MLTX achieves a 25.34% return, which is significantly higher than ^GSPC's -3.95% return.

MLTX

• 1D: -11.37%
• 1M: -6.56%
• YTD: 25.34%
• 6M: 133.99%
• 1Y: -54.55%
• 3Y*: -8.25%
• 5Y*: 9.99%
• 10Y*: —

^GSPC

• 1D: 0.72%
• 1M: -4.45%
• YTD: -3.95%
• 6M: -2.02%
• 1Y: 16.73%
• 3Y*: 16.96%
• 5Y*: 10.34%
• 10Y*: 12.24%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

MLTX vs. ^GSPC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MLTX

MLTX Risk / Return Rank: 36
MLTX Sharpe Ratio Rank: 20
MLTX Sortino Ratio Rank: 52
MLTX Omega Ratio Rank: 70
MLTX Calmar Ratio Rank: 19
MLTX Martin Ratio Rank: 22

^GSPC

^GSPC Risk / Return Rank: 67
^GSPC Sharpe Ratio Rank: 63
^GSPC Sortino Ratio Rank: 64
^GSPC Omega Ratio Rank: 69
^GSPC Calmar Ratio Rank: 60
^GSPC Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MLTX vs. ^GSPC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for MoonLake Immunotherapeutics (MLTX) and S&P 500 Index (^GSPC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MLTX	^GSPC	Difference
Sharpe ratio Return per unit of total volatility	-0.47	0.92	-1.39
Sortino ratio Return per unit of downside risk	0.90	1.41	-0.52
Omega ratio Gain probability vs. loss probability	1.22	1.21	+0.01
Calmar ratio Return relative to maximum drawdown	-0.64	1.41	-2.06
Martin ratio Return relative to average drawdown	-1.04	6.61	-7.65
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MLTX vs. ^GSPC - Sharpe Ratio Comparison

The current MLTX Sharpe Ratio is -0.47, which is lower than the ^GSPC Sharpe Ratio of 0.92. The chart below compares the historical Sharpe Ratios of MLTX and ^GSPC, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	MLTX	^GSPC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.47	0.92	-1.39
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.11	0.61	-0.50
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.68	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.10	0.46	-0.36

Correlation

The correlation between MLTX and ^GSPC is 0.16, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Drawdowns

MLTX vs. ^GSPC - Drawdown Comparison

The maximum MLTX drawdown since its inception was -90.22%, which is greater than ^GSPC's maximum drawdown of -56.78%. Use the drawdown chart below to compare losses from any high point for MLTX and ^GSPC.

Drawdown Indicators

	MLTX	^GSPC	Difference
Max Drawdown Largest peak-to-trough decline	-90.22%	-56.78%	-33.44%
Max Drawdown (1Y) Largest decline over 1 year	-89.93%	-12.14%	-77.79%
Max Drawdown (5Y) Largest decline over 5 years	-90.22%	-25.43%	-64.79%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.92%	—
Current Drawdown Current decline from peak	-74.13%	-5.78%	-68.35%
Average Drawdown Average peak-to-trough decline	-27.79%	-10.75%	-17.04%
Ulcer Index Depth and duration of drawdowns from previous peaks	55.51%	2.60%	+52.91%

Volatility

MLTX vs. ^GSPC - Volatility Comparison

MoonLake Immunotherapeutics (MLTX) has a higher volatility of 20.19% compared to S&P 500 Index (^GSPC) at 5.37%. This indicates that MLTX's price experiences larger fluctuations and is considered to be riskier than ^GSPC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MLTX	^GSPC	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.19%	5.37%	+14.82%
Volatility (6M) Calculated over the trailing 6-month period	57.60%	9.55%	+48.05%
Volatility (1Y) Calculated over the trailing 1-year period	116.94%	18.33%	+98.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	90.46%	16.90%	+73.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	87.19%	18.05%	+69.14%