LNTH vs. APLS

Last updated Apr 1, 2026

Compare and contrast key facts about Lantheus Holdings, Inc. (LNTH) and Apellis Pharmaceuticals, Inc. (APLS).

Performance

LNTH vs. APLS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Lantheus Holdings, Inc. (LNTH) and Apellis Pharmaceuticals, Inc. (APLS). The values are adjusted to include any dividend payments, if applicable.

LNTH vs. APLS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
LNTH Lantheus Holdings, Inc.	13.97%	-25.61%	44.29%	21.66%	76.39%	114.16%	-34.23%	31.05%	-23.47%	-10.89%
APLS Apellis Pharmaceuticals, Inc.	60.15%	-21.28%	-46.69%	15.76%	9.37%	-17.34%	86.81%	132.15%	-39.22%	54.67%

Fundamentals

EPS LNTH : $3.43 APLS : $0.27
PE Ratio LNTH : 22.11 APLS : 150.97
PS Ratio LNTH : 3.35 APLS : 4.90
Total Revenue (TTM) LNTH : $1.54B APLS : $689.38M
Gross Profit (TTM) LNTH : $941.95M APLS : $587.15M
EBITDA (TTM) LNTH : $382.55M APLS : $55.43M

Returns By Period

In the year-to-date period, LNTH achieves a 13.97% return, which is significantly lower than APLS's 60.15% return.

LNTH

• 1D: 3.78%
• 1M: 1.25%
• YTD: 13.97%
• 6M: 47.88%
• 1Y: -22.28%
• 3Y*: -2.79%
• 5Y*: 29.28%
• 10Y*: 44.66%

APLS

• 1D: 135.40%
• 1M: 91.94%
• YTD: 60.15%
• 6M: 77.77%
• 1Y: 83.95%
• 3Y*: -15.19%
• 5Y*: -1.46%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

LNTH vs. APLS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

LNTH

LNTH Risk / Return Rank: 27
LNTH Sharpe Ratio Rank: 23
LNTH Sortino Ratio Rank: 25
LNTH Omega Ratio Rank: 24
LNTH Calmar Ratio Rank: 30
LNTH Martin Ratio Rank: 33

APLS

APLS Risk / Return Rank: 76
APLS Sharpe Ratio Rank: 62
APLS Sortino Ratio Rank: 90
APLS Omega Ratio Rank: 90
APLS Calmar Ratio Rank: 72
APLS Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

LNTH vs. APLS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Lantheus Holdings, Inc. (LNTH) and Apellis Pharmaceuticals, Inc. (APLS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	LNTH	APLS	Difference
Sharpe ratio Return per unit of total volatility	-0.43	0.56	-0.99
Sortino ratio Return per unit of downside risk	-0.23	2.83	-3.06
Omega ratio Gain probability vs. loss probability	0.96	1.40	-0.44
Calmar ratio Return relative to maximum drawdown	-0.39	1.51	-1.90
Martin ratio Return relative to average drawdown	-0.56	2.92	-3.48
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

LNTH vs. APLS - Sharpe Ratio Comparison

The current LNTH Sharpe Ratio is -0.43, which is lower than the APLS Sharpe Ratio of 0.56. The chart below compares the historical Sharpe Ratios of LNTH and APLS, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	LNTH	APLS	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.43	0.56	-0.99
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.51	-0.02	+0.53
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.72	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.39	0.16	+0.23

Correlation

The correlation between LNTH and APLS is 0.25, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

LNTH vs. APLS - Dividend Comparison

Neither LNTH nor APLS has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

LNTH vs. APLS - Drawdown Comparison

The maximum LNTH drawdown since its inception was -78.62%, roughly equal to the maximum APLS drawdown of -82.47%. Use the drawdown chart below to compare losses from any high point for LNTH and APLS.

Drawdown Indicators

	LNTH	APLS	Difference
Max Drawdown Largest peak-to-trough decline	-78.62%	-82.47%	+3.85%
Max Drawdown (1Y) Largest decline over 1 year	-53.92%	-43.53%	-10.39%
Max Drawdown (5Y) Largest decline over 5 years	-59.46%	-82.47%	+23.01%
Max Drawdown (10Y) Largest decline over 10 years	-68.52%	—	—
Current Drawdown Current decline from peak	-38.64%	-56.89%	+18.25%
Average Drawdown Average peak-to-trough decline	-28.22%	-36.84%	+8.62%
Ulcer Index Depth and duration of drawdowns from previous peaks	37.92%	22.49%	+15.43%

Volatility

LNTH vs. APLS - Volatility Comparison

The current volatility for Lantheus Holdings, Inc. (LNTH) is 15.01%, while Apellis Pharmaceuticals, Inc. (APLS) has a volatility of 87.24%. This indicates that LNTH experiences smaller price fluctuations and is considered to be less risky than APLS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	LNTH	APLS	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.01%	87.24%	-72.23%
Volatility (6M) Calculated over the trailing 6-month period	25.31%	100.75%	-75.44%
Volatility (1Y) Calculated over the trailing 1-year period	52.54%	149.78%	-97.24%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	57.33%	91.24%	-33.91%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	62.10%	84.22%	-22.12%

Financials