JAGX vs. NDRA

Last updated Jun 4, 2026

JAGX (Jaguar Health, Inc.) and NDRA (ENDRA Life Sciences Inc.) are both stocks. Both are in the Healthcare sector — JAGX in Biotechnology, NDRA in Diagnostics & Research. Over the past 5 years, JAGX returned -95.58%/yr vs -85.65%/yr for NDRA. At a 0.13 correlation, their price movements are largely independent.

Performance

JAGX vs. NDRA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Jaguar Health, Inc. (JAGX) and ENDRA Life Sciences Inc. (NDRA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JAGX achieves a -89.16% return, which is significantly lower than NDRA's 4.42% return.

JAGX

• 1D: -9.32%
• 1M: -10.15%
• YTD: -89.16%
• 6M: -90.10%
• 1Y: -97.58%
• 3Y*: -95.16%
• 5Y*: -95.58%
• 10Y*: -89.20%

NDRA

• 1D: -6.15%
• 1M: -4.25%
• YTD: 4.42%
• 6M: -20.60%
• 1Y: 35.92%
• 3Y*: -87.83%
• 5Y*: -85.65%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

JAGX vs. NDRA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JAGX Jaguar Health, Inc.	-89.16%	-96.31%	-88.88%	-97.68%	-91.64%	-57.46%	1.75%	-95.00%	-89.10%	-73.56%
NDRA ENDRA Life Sciences Inc.	4.42%	-27.64%	-99.83%	-47.91%	-70.58%	-7.76%	-55.36%	12.00%	-69.14%	24.62%

Correlation

The correlation between JAGX and NDRA is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.05
Correlation (5Y) Calculated over the trailing 5-year period	0.13
Correlation (All Time) Calculated using the full available price history since Jul 3, 2017	0.13

Fundamentals

Market Cap JAGX : $6.81M NDRA : $3.72M
EPS JAGX : -$33.07 NDRA : -$9.31
Total Revenue (TTM) JAGX : $11.51M NDRA : $0.00
Gross Profit (TTM) JAGX : $7.74M NDRA : -$117.76K
EBITDA (TTM) JAGX : -$45.91M NDRA : -$3.74M

Return for Risk

JAGX vs. NDRA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JAGX

JAGX Risk / Return Rank: 5
JAGX Sharpe Ratio Rank: 14
JAGX Sortino Ratio Rank: 1
JAGX Omega Ratio Rank: 2
JAGX Calmar Ratio Rank: 0
JAGX Martin Ratio Rank: 7

NDRA

NDRA Risk / Return Rank: 60
NDRA Sharpe Ratio Rank: 49
NDRA Sortino Ratio Rank: 74
NDRA Omega Ratio Rank: 71
NDRA Calmar Ratio Rank: 54
NDRA Martin Ratio Rank: 50

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JAGX vs. NDRA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Jaguar Health, Inc. (JAGX) and ENDRA Life Sciences Inc. (NDRA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	JAGX	NDRA	Difference
Sharpe ratio Return per unit of total volatility	-0.63	0.21	-0.85
Sortino ratio Return per unit of downside risk	-2.35	1.96	-4.31
Omega ratio Gain probability vs. loss probability	0.70	1.24	-0.53
Calmar ratio Return relative to maximum drawdown	-1.00	0.57	-1.57
Martin ratio Return relative to average drawdown	-1.41	0.85	-2.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

JAGX vs. NDRA - Sharpe Ratio Comparison

The current JAGX Sharpe Ratio is -0.63, which is lower than the NDRA Sharpe Ratio of 0.21. The chart below compares the historical Sharpe Ratios of JAGX and NDRA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	JAGX	NDRA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.63	0.21	-0.85
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.69	-0.60	-0.10
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.51	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.52	-0.53	+0.01

Drawdowns

JAGX vs. NDRA - Drawdown Comparison

The maximum JAGX drawdown since its inception was -100.00%, roughly equal to the maximum NDRA drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for JAGX and NDRA.

Drawdown Indicators

	JAGX	NDRA	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-100.00%	0.00%
Max Drawdown (1Y) Largest decline over 1 year	-97.60%	-63.12%	-34.48%
Max Drawdown (3Y) Largest decline over 3 years	-99.99%	-99.93%	-0.06%
Max Drawdown (5Y) Largest decline over 5 years	-100.00%	-100.00%	0.00%
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	—	—
Current Drawdown Current decline from peak	-100.00%	-100.00%	0.00%
Average Drawdown Average peak-to-trough decline	-94.08%	-79.17%	-14.91%
Ulcer Index Depth and duration of drawdowns from previous peaks	69.57%	42.54%	+27.03%

Volatility

JAGX vs. NDRA - Volatility Comparison

Jaguar Health, Inc. (JAGX) has a higher volatility of 37.56% compared to ENDRA Life Sciences Inc. (NDRA) at 26.16%. This indicates that JAGX's price experiences larger fluctuations and is considered to be riskier than NDRA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JAGX	NDRA	Difference
Volatility (1M) Calculated over the trailing 1-month period	37.56%	26.16%	+11.40%
Volatility (6M) Calculated over the trailing 6-month period	141.80%	63.04%	+78.76%
Volatility (1Y) Calculated over the trailing 1-year period	153.89%	170.98%	-17.09%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	137.92%	143.68%	-5.76%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	173.43%	129.20%	+44.23%

Dividends

JAGX vs. NDRA - Dividend Comparison

Neither JAGX nor NDRA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both JAGX and NDRA in my portfolio?

JAGX and NDRA have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JAGX or NDRA?

JAGX has higher volatility (37.56%) compared to NDRA (26.16%). In terms of maximum drawdown, JAGX dropped -100.00% vs NDRA's -100.00%.

Which has better risk-adjusted returns?

NDRA currently has the higher Sharpe Ratio (0.21 vs -0.63), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.