INSP vs. LLY

Last updated Apr 1, 2026

Compare and contrast key facts about Inspire Medical Systems, Inc. (INSP) and Eli Lilly and Company (LLY).

Performance

INSP vs. LLY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Inspire Medical Systems, Inc. (INSP) and Eli Lilly and Company (LLY). The values are adjusted to include any dividend payments, if applicable.

INSP vs. LLY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
INSP Inspire Medical Systems, Inc.	-44.07%	-50.25%	-8.87%	-19.24%	9.48%	22.31%	153.46%	75.64%	69.14%
LLY Eli Lilly and Company	-14.27%	40.25%	33.30%	60.91%	34.26%	66.08%	31.04%	16.14%	50.88%

Fundamentals

Market Cap INSP : $1.51B LLY : $825.96B
EPS INSP : $4.94 LLY : $22.96
PE Ratio INSP : 10.44 LLY : 40.06
PEG Ratio INSP : 0.06 LLY : 0.81
PS Ratio INSP : 1.67 LLY : 12.68
PB Ratio INSP : 1.93 LLY : 31.13
Total Revenue (TTM) INSP : $911.98M LLY : $65.18B
Gross Profit (TTM) INSP : $778.76M LLY : $54.62B
EBITDA (TTM) INSP : $66.00M LLY : $27.94B

Returns By Period

In the year-to-date period, INSP achieves a -44.07% return, which is significantly lower than LLY's -14.27% return.

INSP

• 1D: 2.32%
• 1M: -20.04%
• YTD: -44.07%
• 6M: -30.49%
• 1Y: -67.62%
• 3Y*: -39.60%
• 5Y*: -24.33%
• 10Y*: —

LLY

• 1D: 3.74%
• 1M: -12.57%
• YTD: -14.27%
• 6M: 20.93%
• 1Y: 12.19%
• 3Y*: 39.90%
• 5Y*: 39.16%
• 10Y*: 30.92%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

INSP vs. LLY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

INSP

INSP Risk / Return Rank: 5
INSP Sharpe Ratio Rank: 6
INSP Sortino Ratio Rank: 5
INSP Omega Ratio Rank: 5
INSP Calmar Ratio Rank: 4
INSP Martin Ratio Rank: 7

LLY

LLY Risk / Return Rank: 51
LLY Sharpe Ratio Rank: 53
LLY Sortino Ratio Rank: 48
LLY Omega Ratio Rank: 49
LLY Calmar Ratio Rank: 53
LLY Martin Ratio Rank: 54

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

INSP vs. LLY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Inspire Medical Systems, Inc. (INSP) and Eli Lilly and Company (LLY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	INSP	LLY	Difference
Sharpe ratio Return per unit of total volatility	-0.92	0.29	-1.21
Sortino ratio Return per unit of downside risk	-1.54	0.69	-2.22
Omega ratio Gain probability vs. loss probability	0.78	1.10	-0.31
Calmar ratio Return relative to maximum drawdown	-0.97	0.42	-1.39
Martin ratio Return relative to average drawdown	-1.62	1.02	-2.64
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

INSP vs. LLY - Sharpe Ratio Comparison

The current INSP Sharpe Ratio is -0.92, which is lower than the LLY Sharpe Ratio of 0.29. The chart below compares the historical Sharpe Ratios of INSP and LLY, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	INSP	LLY	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.92	0.29	-1.21
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.41	1.23	-1.63
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	1.04	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.16	0.56	-0.40

Correlation

The correlation between INSP and LLY is 0.16, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

INSP vs. LLY - Dividend Comparison

INSP has not paid dividends to shareholders, while LLY's dividend yield for the trailing twelve months is around 0.68%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
INSP Inspire Medical Systems, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
LLY Eli Lilly and Company	0.68%	0.56%	0.67%	0.78%	1.07%	1.23%	1.75%	1.96%	1.94%	2.46%	2.77%	2.37%

Drawdowns

INSP vs. LLY - Drawdown Comparison

The maximum INSP drawdown since its inception was -84.63%, which is greater than LLY's maximum drawdown of -68.24%. Use the drawdown chart below to compare losses from any high point for INSP and LLY.

Drawdown Indicators

	INSP	LLY	Difference
Max Drawdown Largest peak-to-trough decline	-84.63%	-68.24%	-16.39%
Max Drawdown (1Y) Largest decline over 1 year	-69.03%	-30.26%	-38.77%
Max Drawdown (5Y) Largest decline over 5 years	-84.63%	-34.48%	-50.15%
Max Drawdown (10Y) Largest decline over 10 years	—	-34.48%	—
Current Drawdown Current decline from peak	-84.18%	-17.00%	-67.18%
Average Drawdown Average peak-to-trough decline	-26.31%	-19.25%	-7.06%
Ulcer Index Depth and duration of drawdowns from previous peaks	41.42%	12.39%	+29.03%

Volatility

INSP vs. LLY - Volatility Comparison

Inspire Medical Systems, Inc. (INSP) has a higher volatility of 10.32% compared to Eli Lilly and Company (LLY) at 9.04%. This indicates that INSP's price experiences larger fluctuations and is considered to be riskier than LLY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	INSP	LLY	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.32%	9.04%	+1.28%
Volatility (6M) Calculated over the trailing 6-month period	56.05%	26.21%	+29.84%
Volatility (1Y) Calculated over the trailing 1-year period	73.43%	42.44%	+30.99%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	60.27%	32.14%	+28.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.64%	29.80%	+30.84%

Financials

INSP vs. LLY - Profitability Comparison

The chart below illustrates the profitability comparison between Inspire Medical Systems, Inc. and Eli Lilly and Company over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

INSP - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Inspire Medical Systems, Inc. reported a gross profit of 233.01M and revenue of 269.08M. Therefore, the gross margin over that period was 86.6%.

LLY - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a gross profit of 16.41B and revenue of 19.29B. Therefore, the gross margin over that period was 85.1%.

INSP - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Inspire Medical Systems, Inc. reported an operating income of 46.11M and revenue of 269.08M, resulting in an operating margin of 17.1%.

LLY - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported an operating income of 8.78B and revenue of 19.29B, resulting in an operating margin of 45.5%.

INSP - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Inspire Medical Systems, Inc. reported a net income of 136.09M and revenue of 269.08M, resulting in a net margin of 50.6%.

LLY - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a net income of 6.64B and revenue of 19.29B, resulting in a net margin of 34.4%.