IMMX vs. VMNIX

Last updated Jun 4, 2026

IMMX (Immix Biopharma, Inc.) is a stock, while VMNIX (Vanguard Market Neutral Fund Institutional Shares) is Long-Short fund managed by Vanguard. Over the past 3 years, IMMX returned 60.54%/yr vs 13.30%/yr for VMNIX. At a 0.00 correlation, their price movements are largely independent.

Performance

IMMX vs. VMNIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Immix Biopharma, Inc. (IMMX) and Vanguard Market Neutral Fund Institutional Shares (VMNIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IMMX achieves a 61.38% return, which is significantly higher than VMNIX's 12.09% return.

IMMX

• 1D: 0.90%
• 1M: -10.97%
• YTD: 61.38%
• 6M: 103.37%
• 1Y: 300.00%
• 3Y*: 60.54%
• 5Y*: —
• 10Y*: —

VMNIX

• 1D: 0.45%
• 1M: 0.84%
• YTD: 12.09%
• 6M: 13.72%
• 1Y: 18.13%
• 3Y*: 13.30%
• 5Y*: 12.99%
• 10Y*: 5.07%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IMMX vs. VMNIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IMMX Immix Biopharma, Inc.	61.38%	137.73%	-68.21%	202.18%	-35.67%	-3.00%
VMNIX Vanguard Market Neutral Fund Institutional Shares	12.09%	9.36%	5.84%	12.33%	13.47%	1.78%

Correlation

The correlation between IMMX and VMNIX is -0.06, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.06
Correlation (3Y) Calculated over the trailing 3-year period	0.00
Correlation (All Time) Calculated using the full available price history since Dec 17, 2021	0.00

Return for Risk

IMMX vs. VMNIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IMMX

IMMX Risk / Return Rank: 93
IMMX Sharpe Ratio Rank: 96
IMMX Sortino Ratio Rank: 92
IMMX Omega Ratio Rank: 89
IMMX Calmar Ratio Rank: 95
IMMX Martin Ratio Rank: 93

VMNIX

VMNIX Risk / Return Rank: 63
VMNIX Sharpe Ratio Rank: 59
VMNIX Sortino Ratio Rank: 67
VMNIX Omega Ratio Rank: 55
VMNIX Calmar Ratio Rank: 82
VMNIX Martin Ratio Rank: 51

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IMMX vs. VMNIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Immix Biopharma, Inc. (IMMX) and Vanguard Market Neutral Fund Institutional Shares (VMNIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IMMX	VMNIX	Difference
Sharpe ratio Return per unit of total volatility	3.58	2.26	+1.32
Sortino ratio Return per unit of downside risk	3.56	3.40	+0.16
Omega ratio Gain probability vs. loss probability	1.41	1.41	0.00
Calmar ratio Return relative to maximum drawdown	7.59	3.77	+3.82
Martin ratio Return relative to average drawdown	16.73	10.50	+6.22
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IMMX vs. VMNIX - Sharpe Ratio Comparison

The current IMMX Sharpe Ratio is 3.58, which is higher than the VMNIX Sharpe Ratio of 2.26. The chart below compares the historical Sharpe Ratios of IMMX and VMNIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IMMX	VMNIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.58	2.26	+1.32
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	1.81	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.79	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.19	0.34	-0.15

Drawdowns

IMMX vs. VMNIX - Drawdown Comparison

The maximum IMMX drawdown since its inception was -88.89%, which is greater than VMNIX's maximum drawdown of -27.90%. Use the drawdown chart below to compare losses from any high point for IMMX and VMNIX.

Drawdown Indicators

	IMMX	VMNIX	Difference
Max Drawdown Largest peak-to-trough decline	-88.89%	-27.90%	-60.99%
Max Drawdown (1Y) Largest decline over 1 year	-39.84%	-4.67%	-35.17%
Max Drawdown (3Y) Largest decline over 3 years	-81.57%	-5.36%	-76.21%
Max Drawdown (5Y) Largest decline over 5 years	—	-6.69%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-24.95%	—
Current Drawdown Current decline from peak	-24.10%	0.00%	-24.10%
Average Drawdown Average peak-to-trough decline	-58.71%	-8.76%	-49.95%
Ulcer Index Depth and duration of drawdowns from previous peaks	18.03%	1.74%	+16.29%

Volatility

IMMX vs. VMNIX - Volatility Comparison

Immix Biopharma, Inc. (IMMX) has a higher volatility of 20.91% compared to Vanguard Market Neutral Fund Institutional Shares (VMNIX) at 2.02%. This indicates that IMMX's price experiences larger fluctuations and is considered to be riskier than VMNIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IMMX	VMNIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.91%	2.02%	+18.89%
Volatility (6M) Calculated over the trailing 6-month period	60.52%	5.75%	+54.77%
Volatility (1Y) Calculated over the trailing 1-year period	86.61%	7.81%	+78.80%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	109.41%	7.22%	+102.19%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	109.41%	6.41%	+103.00%

Dividends

IMMX vs. VMNIX - Dividend Comparison

IMMX has not paid dividends to shareholders, while VMNIX's dividend yield for the trailing twelve months is around 3.19%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
IMMX Immix Biopharma, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VMNIX Vanguard Market Neutral Fund Institutional Shares	3.19%	3.59%	5.67%	5.15%	0.78%	0.20%	0.86%	3.23%	1.00%	1.16%	0.45%	0.10%

Frequently Asked Questions

Can I hold both IMMX and VMNIX in my portfolio?

IMMX and VMNIX have a correlation of -0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IMMX or VMNIX?

IMMX has higher volatility (20.91%) compared to VMNIX (2.02%). In terms of maximum drawdown, IMMX dropped -88.89% vs VMNIX's -27.90%.

Which has better risk-adjusted returns?

IMMX currently has the higher Sharpe Ratio (3.58 vs 2.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.