IBB vs. VOO

Last updated Jun 4, 2026

IBB (iShares Nasdaq Biotechnology ETF) and VOO (Vanguard S&P 500 ETF) are both exchange-traded funds - IBB is a Health & Biotech Equities fund tracking the NASDAQ Biotechnology Index, while VOO is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past 10 years, IBB returned 6.23%/yr vs 15.56%/yr for VOO. A 0.65 correlation means they provide meaningful diversification when combined. IBB charges 0.47%/yr vs 0.03%/yr for VOO.

Performance

IBB vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Nasdaq Biotechnology ETF (IBB) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IBB achieves a -0.68% return, which is significantly lower than VOO's 10.91% return. Over the past 10 years, IBB has underperformed VOO with an annualized return of 6.23%, while VOO has yielded a comparatively higher 15.56% annualized return.

IBB

• 1D: 1.97%
• 1M: -1.56%
• YTD: -0.68%
• 6M: -2.57%
• 1Y: 34.50%
• 3Y*: 9.40%
• 5Y*: 2.10%
• 10Y*: 6.23%

VOO

• 1D: -0.70%
• 1M: 5.04%
• YTD: 10.91%
• 6M: 10.93%
• 1Y: 28.04%
• 3Y*: 22.44%
• 5Y*: 13.90%
• 10Y*: 15.56%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBB vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
IBB iShares Nasdaq Biotechnology ETF	-0.68%	27.98%	-2.41%	3.76%	-13.69%	0.95%	26.01%	25.42%	-9.53%	21.08%
VOO Vanguard S&P 500 ETF	10.91%	17.82%	24.98%	26.32%	-18.17%	28.79%	18.32%	31.37%	-4.50%	21.77%

Correlation

The correlation between IBB and VOO is 0.52, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.52
Correlation (3Y) Calculated over the trailing 3-year period	0.57
Correlation (5Y) Calculated over the trailing 5-year period	0.62
Correlation (10Y) Calculated over the trailing 10-year period	0.63
Correlation (All Time) Calculated using the full available price history since Sep 10, 2010	0.65

The correlation between IBB and VOO shifts across timeframes, from 0.52 (1 year) to 0.65 (all time), reflecting how their relationship changes across market environments.

IBB vs. VOO - Sectors Allocation Comparison

Sectors	IBB	VOO
Healthcare	100.0%	8.5%
Basic Materials	-	1.8%
Communication Services	-	11.3%
Consumer Cyclical	-	10.2%
Consumer Defensive	-	4.9%
Energy	-	3.5%
Financial Services	-	11.6%
Industrials	-	8.3%
Real Estate	-	1.9%
Technology	-	35.7%
Utilities	-	2.4%

Return for Risk

IBB vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBB

IBB Risk / Return Rank: 56
IBB Sharpe Ratio Rank: 50
IBB Sortino Ratio Rank: 50
IBB Omega Ratio Rank: 46
IBB Calmar Ratio Rank: 71
IBB Martin Ratio Rank: 62

VOO

VOO Risk / Return Rank: 70
VOO Sharpe Ratio Rank: 71
VOO Sortino Ratio Rank: 70
VOO Omega Ratio Rank: 70
VOO Calmar Ratio Rank: 62
VOO Martin Ratio Rank: 75

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBB vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Nasdaq Biotechnology ETF (IBB) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IBB	VOO	Difference
Sharpe ratio Return per unit of total volatility	1.74	2.39	-0.64
Sortino ratio Return per unit of downside risk	2.50	3.25	-0.75
Omega ratio Gain probability vs. loss probability	1.30	1.43	-0.14
Calmar ratio Return relative to maximum drawdown	3.60	3.16	+0.43
Martin ratio Return relative to average drawdown	11.43	14.73	-3.30
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IBB vs. VOO - Sharpe Ratio Comparison

The current IBB Sharpe Ratio is 1.74, which is comparable to the VOO Sharpe Ratio of 2.39. The chart below compares the historical Sharpe Ratios of IBB and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IBB	VOO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.74	2.39	-0.64
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.10	0.83	-0.74
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.27	0.87	-0.60
Sharpe Ratio (All Time) Calculated using the full available price history	0.26	0.89	-0.63

Drawdowns

IBB vs. VOO - Drawdown Comparison

The maximum IBB drawdown since its inception was -62.85%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for IBB and VOO.

Drawdown Indicators

	IBB	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-62.85%	-33.99%	-28.86%
Max Drawdown (1Y) Largest decline over 1 year	-9.63%	-8.90%	-0.73%
Max Drawdown (3Y) Largest decline over 3 years	-24.85%	-18.69%	-6.16%
Max Drawdown (5Y) Largest decline over 5 years	-39.82%	-24.52%	-15.30%
Max Drawdown (10Y) Largest decline over 10 years	-39.82%	-33.99%	-5.83%
Current Drawdown Current decline from peak	-5.64%	-0.70%	-4.94%
Average Drawdown Average peak-to-trough decline	-21.18%	-3.69%	-17.49%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.03%	1.91%	+1.12%

Volatility

IBB vs. VOO - Volatility Comparison

iShares Nasdaq Biotechnology ETF (IBB) has a higher volatility of 6.86% compared to Vanguard S&P 500 ETF (VOO) at 2.84%. This indicates that IBB's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBB	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.86%	2.84%	+4.02%
Volatility (6M) Calculated over the trailing 6-month period	15.38%	8.90%	+6.48%
Volatility (1Y) Calculated over the trailing 1-year period	19.89%	11.80%	+8.09%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.99%	16.81%	+5.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.22%	18.01%	+5.21%

IBB vs. VOO - Expense Ratio Comparison

IBB has a 0.47% expense ratio, which is higher than VOO's 0.03% expense ratio.

Dividends

IBB vs. VOO - Dividend Comparison

IBB's dividend yield for the trailing twelve months is around 0.23%, less than VOO's 1.03% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
IBB iShares Nasdaq Biotechnology ETF	0.23%	0.23%	0.29%	0.26%	0.31%	0.21%	0.21%	0.33%	0.20%	0.30%	0.19%	0.03%
VOO Vanguard S&P 500 ETF	1.03%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both IBB and VOO in my portfolio?

IBB and VOO have a correlation of 0.52, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBB or VOO?

IBB has higher volatility (6.86%) compared to VOO (2.84%). In terms of maximum drawdown, IBB dropped -62.85% vs VOO's -33.99%.

Which ETF is better, IBB or VOO?

On 10-year performance, VOO leads with 15.56% vs 6.23% for IBB. On fees, VOO is cheaper at 0.03% per year. On volatility, VOO has been the lower-risk option at 2.84%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBB or VOO?

Over the 10-year period, VOO has performed better with a 15.56% return vs 6.23%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBB or VOO?

VOO is cheaper with a 0.03% expense ratio, compared with 0.47% for IBB.

Which ETF pays a higher dividend yield, IBB or VOO?

VOO has the higher dividend yield at 1.03%, compared with 0.23% for IBB.

What is the main difference between IBB and VOO?

IBB is categorized as Health & Biotech Equities, while VOO is S&P 500. IBB tracks NASDAQ Biotechnology Index, while VOO tracks S&P 500 Index. They also come from different issuers: iShares and Vanguard. Their fees differ too: 0.47% for IBB and 0.03% for VOO.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.39 vs 1.74), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.