HRTX vs. SGMO

Last updated Apr 2, 2026

Compare and contrast key facts about Heron Therapeutics, Inc. (HRTX) and Sangamo Therapeutics, Inc. (SGMO).

Performance

HRTX vs. SGMO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Heron Therapeutics, Inc. (HRTX) and Sangamo Therapeutics, Inc. (SGMO). The values are adjusted to include any dividend payments, if applicable.

HRTX vs. SGMO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
HRTX Heron Therapeutics, Inc.	-38.19%	-15.03%	-10.00%	-32.00%	-72.62%	-56.86%	-9.94%	-9.41%	43.31%	38.17%
SGMO Sangamo Therapeutics, Inc.	-38.07%	-58.82%	87.74%	-82.70%	-58.13%	-51.94%	86.44%	-27.09%	-30.00%	437.70%

Fundamentals

Market Cap HRTX : $133.95M SGMO : $87.84M
EPS HRTX : -$0.12 SGMO : -$0.41
PS Ratio HRTX : 0.85 SGMO : 1.97
Total Revenue (TTM) HRTX : $154.90M SGMO : $39.55M
Gross Profit (TTM) HRTX : $113.56M SGMO : $25.32M
EBITDA (TTM) HRTX : -$10.10M SGMO : -$117.16M

Returns By Period

The year-to-date returns for both investments are quite close, with HRTX having a -38.19% return and SGMO slightly higher at -38.07%. Both investments have delivered pretty close results over the past 10 years, with HRTX having a -27.81% annualized return and SGMO not far ahead at -27.19%.

HRTX

• 1D: 0.42%
• 1M: -33.04%
• YTD: -38.19%
• 6M: -35.72%
• 1Y: -61.92%
• 3Y*: -18.97%
• 5Y*: -45.42%
• 10Y*: -27.81%

SGMO

• 1D: 5.35%
• 1M: -39.50%
• YTD: -38.07%
• 6M: -61.44%
• 1Y: -54.38%
• 3Y*: -47.13%
• 5Y*: -53.74%
• 10Y*: -27.19%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

HRTX vs. SGMO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

HRTX

HRTX Risk / Return Rank: 6
HRTX Sharpe Ratio Rank: 5
HRTX Sortino Ratio Rank: 5
HRTX Omega Ratio Rank: 6
HRTX Calmar Ratio Rank: 6
HRTX Martin Ratio Rank: 8

SGMO

SGMO Risk / Return Rank: 16
SGMO Sharpe Ratio Rank: 18
SGMO Sortino Ratio Rank: 23
SGMO Omega Ratio Rank: 23
SGMO Calmar Ratio Rank: 9
SGMO Martin Ratio Rank: 8

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

HRTX vs. SGMO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Heron Therapeutics, Inc. (HRTX) and Sangamo Therapeutics, Inc. (SGMO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	HRTX	SGMO	Difference
Sharpe ratio Return per unit of total volatility	-0.96	-0.51	-0.45
Sortino ratio Return per unit of downside risk	-1.50	-0.26	-1.24
Omega ratio Gain probability vs. loss probability	0.82	0.97	-0.15
Calmar ratio Return relative to maximum drawdown	-0.92	-0.87	-0.05
Martin ratio Return relative to average drawdown	-1.53	-1.54	+0.01
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

HRTX vs. SGMO - Sharpe Ratio Comparison

The current HRTX Sharpe Ratio is -0.96, which is lower than the SGMO Sharpe Ratio of -0.51. The chart below compares the historical Sharpe Ratios of HRTX and SGMO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	HRTX	SGMO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.96	-0.51	-0.45
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.52	-0.51	-0.01
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.37	-0.29	-0.09
Sharpe Ratio (All Time) Calculated using the full available price history	-0.20	-0.16	-0.03

Correlation

The correlation between HRTX and SGMO is 0.23, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

HRTX vs. SGMO - Dividend Comparison

Neither HRTX nor SGMO has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

HRTX vs. SGMO - Drawdown Comparison

The maximum HRTX drawdown since its inception was -99.96%, roughly equal to the maximum SGMO drawdown of -99.50%. Use the drawdown chart below to compare losses from any high point for HRTX and SGMO.

Drawdown Indicators

	HRTX	SGMO	Difference
Max Drawdown Largest peak-to-trough decline	-99.96%	-99.50%	-0.46%
Max Drawdown (1Y) Largest decline over 1 year	-69.18%	-69.70%	+0.52%
Max Drawdown (5Y) Largest decline over 5 years	-97.08%	-98.05%	+0.97%
Max Drawdown (10Y) Largest decline over 10 years	-98.71%	-99.06%	+0.35%
Current Drawdown Current decline from peak	-99.94%	-99.48%	-0.46%
Average Drawdown Average peak-to-trough decline	-81.58%	-83.93%	+2.35%
Ulcer Index Depth and duration of drawdowns from previous peaks	41.53%	39.13%	+2.40%

Volatility

HRTX vs. SGMO - Volatility Comparison

The current volatility for Heron Therapeutics, Inc. (HRTX) is 19.10%, while Sangamo Therapeutics, Inc. (SGMO) has a volatility of 28.34%. This indicates that HRTX experiences smaller price fluctuations and is considered to be less risky than SGMO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	HRTX	SGMO	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.10%	28.34%	-9.24%
Volatility (6M) Calculated over the trailing 6-month period	40.77%	78.81%	-38.04%
Volatility (1Y) Calculated over the trailing 1-year period	65.05%	108.44%	-43.39%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	87.85%	106.51%	-18.66%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	74.45%	95.01%	-20.56%

Financials