HOLX vs. ISRG

Last updated Jun 3, 2026

HOLX (Hologic, Inc.) and ISRG (Intuitive Surgical, Inc.) are both stocks. Both operate in the Medical Instruments & Supplies industry within the Healthcare sector. At a 0.36 correlation, their price movements are largely independent.

Performance

HOLX vs. ISRG - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Hologic, Inc. (HOLX) and Intuitive Surgical, Inc. (ISRG). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

HOLX

• 1D: —
• 1M: —
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

ISRG

• 1D: -2.42%
• 1M: -12.12%
• YTD: -28.97%
• 6M: -29.14%
• 1Y: -27.29%
• 3Y*: 8.82%
• 5Y*: 8.13%
• 10Y*: 18.98%

*Multi-year figures are annualized to reflect compound growth (CAGR)

HOLX vs. ISRG - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
HOLX Hologic, Inc.	2.04%	3.33%	0.90%	-4.49%	-2.29%	5.12%	39.49%	27.03%	-3.86%	6.56%
ISRG Intuitive Surgical, Inc.	-28.97%	8.51%	54.72%	27.14%	-26.15%	31.76%	38.39%	23.43%	31.23%	72.64%

Correlation

The correlation between HOLX and ISRG is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.22
Correlation (5Y) Calculated over the trailing 5-year period	0.36
Correlation (10Y) Calculated over the trailing 10-year period	0.43
Correlation (All Time) Calculated using the full available price history since Jun 19, 2000	0.36

The correlation between HOLX and ISRG shifts across timeframes, from 0.22 (3 years) to 0.43 (10 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap HOLX : $17.17B ISRG : $144.75B
EPS HOLX : $2.41 ISRG : $8.24
PE Ratio HOLX : 31.54 ISRG : 48.82
PS Ratio HOLX : 4.16 ISRG : 13.74
PB Ratio HOLX : 3.27 ISRG : 8.23
Total Revenue (TTM) HOLX : $4.13B ISRG : $10.58B
Gross Profit (TTM) HOLX : $2.18B ISRG : $7.02B
EBITDA (TTM) HOLX : $1.01B ISRG : $3.76B

Return for Risk

HOLX vs. ISRG — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ISRG

ISRG Risk / Return Rank: 6
ISRG Sharpe Ratio Rank: 6
ISRG Sortino Ratio Rank: 7
ISRG Omega Ratio Rank: 9
ISRG Calmar Ratio Rank: 8
ISRG Martin Ratio Rank: 2

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

HOLX vs. ISRG - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Hologic, Inc. (HOLX) and Intuitive Surgical, Inc. (ISRG). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	HOLX	ISRG	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	-0.89	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.25	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.59	—
Sharpe Ratio (All Time) Calculated using the full available price history	—	0.47	—

Drawdowns

Drawdown Indicators

	HOLX	ISRG	Difference
Max Drawdown Largest peak-to-trough decline	—	-82.26%	—
Max Drawdown (1Y) Largest decline over 1 year	—	-32.14%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-34.10%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-49.90%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-49.90%	—
Current Drawdown Current decline from peak	—	-34.10%	—
Average Drawdown Average peak-to-trough decline	—	-21.27%	—
Ulcer Index Depth and duration of drawdowns from previous peaks	—	15.79%	—

Volatility

Volatility by Period

	HOLX	ISRG	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	10.94%	—
Volatility (6M) Calculated over the trailing 6-month period	—	20.19%	—
Volatility (1Y) Calculated over the trailing 1-year period	—	30.80%	—
Volatility (5Y) Calculated over the trailing 5-year period, annualized	—	33.15%	—
Volatility (10Y) Calculated over the trailing 10-year period, annualized	—	32.38%	—

Dividends

HOLX vs. ISRG - Dividend Comparison

Neither HOLX nor ISRG has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

HOLX vs. ISRG - Profitability Comparison

The chart below illustrates the profitability comparison between Hologic, Inc. and Intuitive Surgical, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

HOLX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Hologic, Inc. reported a gross profit of 586.40M and revenue of 1.05B. Therefore, the gross margin over that period was 56.0%.

ISRG - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a gross profit of 1.83B and revenue of 2.77B. Therefore, the gross margin over that period was 66.1%.

HOLX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Hologic, Inc. reported an operating income of 237.00M and revenue of 1.05B, resulting in an operating margin of 22.6%.

ISRG - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported an operating income of 855.30M and revenue of 2.77B, resulting in an operating margin of 30.9%.

HOLX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Hologic, Inc. reported a net income of 179.10M and revenue of 1.05B, resulting in a net margin of 17.1%.

ISRG - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a net income of 821.50M and revenue of 2.77B, resulting in a net margin of 29.7%.

Frequently Asked Questions

Can I hold both HOLX and ISRG in my portfolio?

HOLX and ISRG have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.