GSK vs. PFE

Last updated Apr 1, 2026

Compare and contrast key facts about GlaxoSmithKline plc (GSK) and Pfizer Inc. (PFE).

Performance

GSK vs. PFE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in GlaxoSmithKline plc (GSK) and Pfizer Inc. (PFE). The values are adjusted to include any dividend payments, if applicable.

GSK vs. PFE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
GSK GlaxoSmithKline plc	13.45%	51.23%	-5.14%	9.71%	-33.41%	26.74%	-17.72%	29.24%	13.79%	-2.97%
PFE Pfizer Inc.	14.66%	0.65%	-2.22%	-41.26%	-10.41%	66.70%	3.07%	-6.91%	24.82%	15.90%

Fundamentals

Market Cap GSK : $112.75B PFE : $159.66B
EPS GSK : $2.78 PFE : $1.36
PE Ratio GSK : 19.82 PFE : 20.61
PEG Ratio GSK : 1.33 PFE : 0.37
PS Ratio GSK : 3.54 PFE : 2.56
PB Ratio GSK : 6.90 PFE : 1.72
Total Revenue (TTM) GSK : $31.95B PFE : $62.58B
Gross Profit (TTM) GSK : $23.18B PFE : $44.01B
EBITDA (TTM) GSK : $11.62B PFE : $15.10B

Returns By Period

In the year-to-date period, GSK achieves a 13.45% return, which is significantly lower than PFE's 14.66% return. Over the past 10 years, GSK has outperformed PFE with an annualized return of 5.74%, while PFE has yielded a comparatively lower 4.32% annualized return.

GSK

• 1D: 1.77%
• 1M: -6.66%
• YTD: 13.45%
• 6M: 30.03%
• 1Y: 48.15%
• 3Y*: 20.43%
• 5Y*: 8.75%
• 10Y*: 5.74%

PFE

• 1D: 1.12%
• 1M: 1.56%
• YTD: 14.66%
• 6M: 14.02%
• 1Y: 18.86%
• 3Y*: -6.22%
• 5Y*: -0.14%
• 10Y*: 4.32%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

GSK vs. PFE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GSK

GSK Risk / Return Rank: 85
GSK Sharpe Ratio Rank: 88
GSK Sortino Ratio Rank: 84
GSK Omega Ratio Rank: 81
GSK Calmar Ratio Rank: 88
GSK Martin Ratio Rank: 85

PFE

PFE Risk / Return Rank: 65
PFE Sharpe Ratio Rank: 67
PFE Sortino Ratio Rank: 61
PFE Omega Ratio Rank: 59
PFE Calmar Ratio Rank: 69
PFE Martin Ratio Rank: 69

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GSK vs. PFE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for GlaxoSmithKline plc (GSK) and Pfizer Inc. (PFE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	GSK	PFE	Difference
Sharpe ratio Return per unit of total volatility	1.70	0.71	+0.99
Sortino ratio Return per unit of downside risk	2.30	1.17	+1.13
Omega ratio Gain probability vs. loss probability	1.29	1.15	+0.15
Calmar ratio Return relative to maximum drawdown	3.25	1.32	+1.94
Martin ratio Return relative to average drawdown	7.56	3.18	+4.39
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

GSK vs. PFE - Sharpe Ratio Comparison

The current GSK Sharpe Ratio is 1.70, which is higher than the PFE Sharpe Ratio of 0.71. The chart below compares the historical Sharpe Ratios of GSK and PFE, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	GSK	PFE	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.70	0.71	+0.99
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.36	-0.01	+0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.25	0.18	+0.07
Sharpe Ratio (All Time) Calculated using the full available price history	0.33	0.26	+0.07

Correlation

The correlation between GSK and PFE is 0.43, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.

Dividends

GSK vs. PFE - Dividend Comparison

GSK's dividend yield for the trailing twelve months is around 3.19%, less than PFE's 6.13% yield.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GSK GlaxoSmithKline plc	3.19%	3.42%	4.60%	3.75%	5.47%	4.99%	5.59%	4.35%	5.65%	5.83%	6.86%	5.93%
PFE Pfizer Inc.	6.13%	6.91%	6.33%	5.70%	3.12%	2.64%	3.92%	3.68%	3.12%	3.53%	3.69%	3.47%

Drawdowns

GSK vs. PFE - Drawdown Comparison

The maximum GSK drawdown since its inception was -55.70%, smaller than the maximum PFE drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for GSK and PFE.

Drawdown Indicators

	GSK	PFE	Difference
Max Drawdown Largest peak-to-trough decline	-55.70%	-58.96%	+3.26%
Max Drawdown (1Y) Largest decline over 1 year	-14.80%	-12.59%	-2.21%
Max Drawdown (5Y) Largest decline over 5 years	-50.10%	-58.96%	+8.86%
Max Drawdown (10Y) Largest decline over 10 years	-50.10%	-58.96%	+8.86%
Current Drawdown Current decline from peak	-9.07%	-42.75%	+33.68%
Average Drawdown Average peak-to-trough decline	-18.90%	-17.33%	-1.57%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.37%	6.13%	+0.24%

Volatility

GSK vs. PFE - Volatility Comparison

GlaxoSmithKline plc (GSK) has a higher volatility of 7.26% compared to Pfizer Inc. (PFE) at 6.75%. This indicates that GSK's price experiences larger fluctuations and is considered to be riskier than PFE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GSK	PFE	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.26%	6.75%	+0.51%
Volatility (6M) Calculated over the trailing 6-month period	19.71%	18.50%	+1.21%
Volatility (1Y) Calculated over the trailing 1-year period	28.43%	26.73%	+1.70%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.74%	25.46%	-0.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.72%	23.90%	-1.18%

Financials

GSK vs. PFE - Profitability Comparison

The chart below illustrates the profitability comparison between GlaxoSmithKline plc and Pfizer Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

GSK - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, GlaxoSmithKline plc reported a gross profit of 5.49B and revenue of 7.90B. Therefore, the gross margin over that period was 69.5%.

PFE - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Pfizer Inc. reported a gross profit of 12.29B and revenue of 17.56B. Therefore, the gross margin over that period was 70.0%.

GSK - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, GlaxoSmithKline plc reported an operating income of 179.89M and revenue of 7.90B, resulting in an operating margin of 2.3%.

PFE - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Pfizer Inc. reported an operating income of 3.69B and revenue of 17.56B, resulting in an operating margin of 21.0%.

GSK - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, GlaxoSmithKline plc reported a net income of 627.73M and revenue of 7.90B, resulting in a net margin of 7.9%.

PFE - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Pfizer Inc. reported a net income of -1.65B and revenue of 17.56B, resulting in a net margin of -9.4%.