FOLD vs. USMV

Last updated Apr 1, 2026

Compare and contrast key facts about Amicus Therapeutics, Inc. (FOLD) and iShares MSCI USA Minimum Volatility Factor ETF (USMV).

USMV is a passively managed fund by iShares that tracks the performance of the MSCI USA Minimum Volatility Index. It was launched on Oct 18, 2011.

Performance

FOLD vs. USMV - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amicus Therapeutics, Inc. (FOLD) and iShares MSCI USA Minimum Volatility Factor ETF (USMV). The values are adjusted to include any dividend payments, if applicable.

FOLD vs. USMV - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
FOLD Amicus Therapeutics, Inc.	1.54%	51.17%	-33.62%	16.22%	5.71%	-49.98%	137.06%	1.67%	-33.43%	189.54%
USMV iShares MSCI USA Minimum Volatility Factor ETF	-1.10%	7.65%	15.74%	10.33%	-9.43%	20.85%	5.64%	27.69%	1.33%	18.91%

Returns By Period

In the year-to-date period, FOLD achieves a 1.54% return, which is significantly higher than USMV's -1.10% return. Over the past 10 years, FOLD has underperformed USMV with an annualized return of 5.22%, while USMV has yielded a comparatively higher 9.65% annualized return.

FOLD

• 1D: 0.21%
• 1M: 0.63%
• YTD: 1.54%
• 6M: 83.50%
• 1Y: 77.21%
• 3Y*: 9.25%
• 5Y*: 7.53%
• 10Y*: 5.22%

USMV

• 1D: 1.15%
• 1M: -4.79%
• YTD: -1.10%
• 6M: -1.72%
• 1Y: 0.57%
• 3Y*: 10.28%
• 5Y*: 7.61%
• 10Y*: 9.65%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

FOLD vs. USMV — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FOLD

FOLD Risk / Return Rank: 84
FOLD Sharpe Ratio Rank: 86
FOLD Sortino Ratio Rank: 88
FOLD Omega Ratio Rank: 90
FOLD Calmar Ratio Rank: 80
FOLD Martin Ratio Rank: 77

USMV

USMV Risk / Return Rank: 15
USMV Sharpe Ratio Rank: 14
USMV Sortino Ratio Rank: 12
USMV Omega Ratio Rank: 13
USMV Calmar Ratio Rank: 17
USMV Martin Ratio Rank: 19

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FOLD vs. USMV - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amicus Therapeutics, Inc. (FOLD) and iShares MSCI USA Minimum Volatility Factor ETF (USMV). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	FOLD	USMV	Difference
Sharpe ratio Return per unit of total volatility	1.63	0.05	+1.58
Sortino ratio Return per unit of downside risk	2.67	0.15	+2.52
Omega ratio Gain probability vs. loss probability	1.40	1.02	+0.38
Calmar ratio Return relative to maximum drawdown	2.32	0.18	+2.14
Martin ratio Return relative to average drawdown	5.16	0.79	+4.38
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

FOLD vs. USMV - Sharpe Ratio Comparison

The current FOLD Sharpe Ratio is 1.63, which is higher than the USMV Sharpe Ratio of 0.05. The chart below compares the historical Sharpe Ratios of FOLD and USMV, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	FOLD	USMV	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.63	0.05	+1.58
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.16	0.62	-0.46
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.09	0.67	-0.57
Sharpe Ratio (All Time) Calculated using the full available price history	0.00	0.85	-0.85

Correlation

The correlation between FOLD and USMV is 0.31, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

FOLD vs. USMV - Dividend Comparison

FOLD has not paid dividends to shareholders, while USMV's dividend yield for the trailing twelve months is around 1.58%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FOLD Amicus Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
USMV iShares MSCI USA Minimum Volatility Factor ETF	1.58%	1.49%	1.67%	1.82%	1.62%	1.26%	1.81%	1.88%	2.12%	1.77%	2.22%	2.02%

Drawdowns

FOLD vs. USMV - Drawdown Comparison

The maximum FOLD drawdown since its inception was -89.91%, which is greater than USMV's maximum drawdown of -33.10%. Use the drawdown chart below to compare losses from any high point for FOLD and USMV.

Drawdown Indicators

	FOLD	USMV	Difference
Max Drawdown Largest peak-to-trough decline	-89.91%	-33.10%	-56.81%
Max Drawdown (1Y) Largest decline over 1 year	-29.50%	-8.91%	-20.59%
Max Drawdown (5Y) Largest decline over 5 years	-61.16%	-17.93%	-43.23%
Max Drawdown (10Y) Largest decline over 10 years	-77.34%	-33.10%	-44.24%
Current Drawdown Current decline from peak	-41.90%	-4.79%	-37.11%
Average Drawdown Average peak-to-trough decline	-53.81%	-2.88%	-50.93%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.86%	2.00%	+11.86%

Volatility

FOLD vs. USMV - Volatility Comparison

The current volatility for Amicus Therapeutics, Inc. (FOLD) is 0.56%, while iShares MSCI USA Minimum Volatility Factor ETF (USMV) has a volatility of 3.03%. This indicates that FOLD experiences smaller price fluctuations and is considered to be less risky than USMV based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	FOLD	USMV	Difference
Volatility (1M) Calculated over the trailing 1-month period	0.56%	3.03%	-2.47%
Volatility (6M) Calculated over the trailing 6-month period	30.44%	6.08%	+24.36%
Volatility (1Y) Calculated over the trailing 1-year period	47.84%	12.54%	+35.30%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	47.15%	12.39%	+34.76%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	55.54%	14.51%	+41.03%