ETHSX vs. AGEN

Last updated Jul 14, 2026

ETHSX (Eaton Vance Worldwide Health Sciences Fund) is Health & Biotech Equities fund managed by Eaton Vance, while AGEN (Agenus Inc.) is a stock. Over the past 10 years, ETHSX returned 7.69%/yr vs -23.86%/yr for AGEN. At a 0.36 correlation, their price movements are largely independent.

Performance

ETHSX vs. AGEN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Eaton Vance Worldwide Health Sciences Fund (ETHSX) and Agenus Inc. (AGEN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ETHSX achieves a -0.30% return, which is significantly lower than AGEN's 94.90% return. Over the past 10 years, ETHSX has outperformed AGEN with an annualized return of 7.69%, while AGEN has yielded a comparatively lower -23.86% annualized return.

ETHSX

• 1D: -1.27%
• 1M: 5.00%
• 6M: -1.93%
• YTD: -0.30%
• 1Y: 10.67%
• 3Y*: 6.23%
• 5Y*: 3.49%
• 10Y*: 7.69%

AGEN

• 1D: 82.69%
• 1M: 85.45%
• 6M: 44.00%
• YTD: 94.90%
• 1Y: -13.31%
• 3Y*: -44.19%
• 5Y*: -43.74%
• 10Y*: -23.86%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ETHSX vs. AGEN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ETHSX Eaton Vance Worldwide Health Sciences Fund	-0.30%	10.23%	3.48%	5.67%	-9.41%	22.02%	13.04%	25.99%	5.87%	16.24%
AGEN Agenus Inc.	94.90%	14.60%	-83.45%	-64.85%	-25.47%	1.26%	-21.87%	71.01%	-26.99%	-20.87%

Correlation

The correlation between ETHSX and AGEN is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.34
Correlation (10Y) Calculated over the trailing 10-year period	0.35
Correlation (All Time) Calculated using the full available price history since Feb 8, 2000	0.36

Return for Risk

ETHSX vs. AGEN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ETHSX

ETHSX Risk / Return Rank: 10
ETHSX Sharpe Ratio Rank: 10
ETHSX Sortino Ratio Rank: 11
ETHSX Omega Ratio Rank: 10
ETHSX Calmar Ratio Rank: 11
ETHSX Martin Ratio Rank: 9

AGEN

AGEN Risk / Return Rank: 44
AGEN Sharpe Ratio Rank: 41
AGEN Sortino Ratio Rank: 52
AGEN Omega Ratio Rank: 51
AGEN Calmar Ratio Rank: 38
AGEN Martin Ratio Rank: 39

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ETHSX vs. AGEN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Eaton Vance Worldwide Health Sciences Fund (ETHSX) and Agenus Inc. (AGEN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ETHSX	AGEN	Difference
Sharpe ratio: Return per unit of total volatility	0.57	-0.12	+0.69
Sortino ratio: Return per unit of downside risk	0.98	0.71	+0.27
Omega ratio: Gain probability vs. loss probability	1.11	1.08	+0.02
Calmar ratio: Return relative to maximum drawdown	0.75	-0.22	+0.97
Martin ratio: Return relative to average drawdown	1.70	-0.30	+2.00

ETHSX vs. AGEN - Sharpe Ratio Comparison

The current ETHSX Sharpe Ratio is 0.57, which is higher than the AGEN Sharpe Ratio of -0.12. The chart below compares the historical Sharpe Ratios of ETHSX and AGEN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ETHSX vs. AGEN - Drawdown Comparison

The maximum ETHSX drawdown since its inception was -90.06%, smaller than the maximum AGEN drawdown of -99.98%. Use the drawdown chart below to compare losses from any high point for ETHSX and AGEN.

Drawdown Indicators

	ETHSX	AGEN	Difference
Max Drawdown Largest peak-to-trough decline	-90.06%	-99.98%	+9.92%
Max Drawdown (1Y) Largest decline over 1 year	-12.35%	-59.44%	+47.09%
Max Drawdown (3Y) Largest decline over 3 years	-18.91%	-95.72%	+76.81%
Max Drawdown (5Y) Largest decline over 5 years	-19.58%	-98.84%	+79.26%
Max Drawdown (10Y) Largest decline over 10 years	-27.43%	-98.96%	+71.53%
Current Drawdown Current decline from peak	-5.08%	-99.90%	+94.82%
Average Drawdown Average peak-to-trough decline	-43.89%	-93.69%	+49.80%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.44%	45.74%	-40.30%

Volatility

ETHSX vs. AGEN - Volatility Comparison

The current volatility for Eaton Vance Worldwide Health Sciences Fund (ETHSX) is 6.16%, while Agenus Inc. (AGEN) has a volatility of 63.75%. This indicates that ETHSX experiences smaller price fluctuations and is considered to be less risky than AGEN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ETHSX	AGEN	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.16%	63.75%	-57.59%
Volatility (6M) Calculated over the trailing 6-month period	11.93%	88.21%	-76.28%
Volatility (1Y) Calculated over the trailing 1-year period	16.17%	115.35%	-99.18%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	15.18%	103.08%	-87.90%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	16.29%	87.46%	-71.17%

Dividends

ETHSX vs. AGEN - Dividend Comparison

ETHSX's dividend yield for the trailing twelve months is around 7.39%, while AGEN has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AGEN Agenus Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
ETHSX Eaton Vance Worldwide Health Sciences Fund	7.39%	7.36%	4.81%	2.48%	4.43%	8.25%	7.33%	5.39%	5.51%	2.82%	12.75%	9.70%

Frequently Asked Questions

Can I hold both ETHSX and AGEN in my portfolio?

ETHSX and AGEN have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ETHSX or AGEN?

AGEN has higher volatility (63.75%) compared to ETHSX (6.16%). In terms of maximum drawdown, ETHSX dropped -90.06% vs AGEN's -99.98%.

Which has better risk-adjusted returns?

ETHSX currently has the higher Sharpe Ratio (0.57 vs -0.12), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.