PortfoliosLab logoPortfoliosLab logo

Documentation

Upgrade your plan
DNA vs. VOO
Performance
Return for Risk
Drawdowns
Volatility
Dividends

DNA vs. VOO

Last updated Jun 5, 2026

DNA (Ginkgo Bioworks Holdings, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 5 years, DNA returned -53.00%/yr vs 13.98%/yr for VOO. At a 0.45 correlation, their price movements are largely independent.

Performance

DNA vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ginkgo Bioworks Holdings, Inc. (DNA) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Loading charts...

Returns By Period

In the year-to-date period, DNA achieves a 8.90% return, which is significantly lower than VOO's 11.34% return.

DNA

1D
3.67%
1M
-6.80%
YTD
8.90%
6M
-1.74%
1Y
19.71%
3Y*
-48.43%
5Y*
-53.00%
10Y*
—

VOO

1D
0.39%
1M
4.62%
YTD
11.34%
6M
11.27%
1Y
28.62%
3Y*
22.68%
5Y*
13.98%
10Y*
15.55%
*Multi-year figures are annualized to reflect compound growth (CAGR)

DNA vs. VOO - Yearly Performance Comparison

2026 (YTD)20252024202320222021
DNA
Ginkgo Bioworks Holdings, Inc.		8.90%-15.38%-85.47%0.00%-79.66%-17.89%
VOO
Vanguard S&P 500 ETF		11.34%17.82%24.98%26.32%-18.17%15.55%

Correlation

The correlation between DNA and VOO is 0.43, which is low. Their price movements are largely independent, making them effective diversification partners.

Correlation
Correlation (1Y)
Calculated over the trailing 1-year period

0.43

Correlation (3Y)
Calculated over the trailing 3-year period

0.44

Correlation (5Y)
Calculated over the trailing 5-year period

0.46

Correlation (All Time)
Calculated using the full available price history since Apr 20, 2021

0.45

Compare stocks, funds, or ETFs

Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.

Ginkgo Bioworks Holdings, Inc.

Vanguard S&P 500 ETF

Often compared with DNA:
DNA vs. PLTRDNA vs. WBADNA vs. MRNADNA vs. ARDXDNA vs. VIRDNA vs. NWBODNA vs. INVZ
Often compared with VOO:
VOO vs. VTIVOO vs. QQQVOO vs. SCHDVOO vs. VTVOO vs. SPYVOO vs. FXAIXVOO vs. IVV

Return for Risk

DNA vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
DNA
DNA Risk / Return Rank: 5151
Overall Rank
DNA Sharpe Ratio Rank: 4949
Sharpe Ratio Rank
DNA Sortino Ratio Rank: 5555
Sortino Ratio Rank
DNA Omega Ratio Rank: 5454
Omega Ratio Rank
DNA Calmar Ratio Rank: 4949
Calmar Ratio Rank
DNA Martin Ratio Rank: 4848
Martin Ratio Rank
VOO
VOO Risk / Return Rank: 7474
Overall Rank
VOO Sharpe Ratio Rank: 7676
Sharpe Ratio Rank
VOO Sortino Ratio Rank: 7575
Sortino Ratio Rank
VOO Omega Ratio Rank: 7575
Omega Ratio Rank
VOO Calmar Ratio Rank: 6666
Calmar Ratio Rank
VOO Martin Ratio Rank: 7878
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

DNA vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ginkgo Bioworks Holdings, Inc. (DNA) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

DNAVOODifference
Sharpe ratioReturn per unit of total volatility
0.20
2.44

-2.24

Sortino ratioReturn per unit of downside risk
1.00
3.31

-2.31

Omega ratioGain probability vs. loss probability

1.13

1.44

-0.32

Calmar ratioReturn relative to maximum drawdown

0.30

3.23

-2.93

Martin ratioReturn relative to average drawdown

0.52

15.03

-14.52

Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

DNA vs. VOO - Sharpe Ratio Comparison

The current DNA Sharpe Ratio is 0.20, which is lower than the VOO Sharpe Ratio of 2.44. The chart below compares the historical Sharpe Ratios of DNA and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Loading charts...

Sharpe Ratios by Period

DNAVOODifference

Sharpe Ratio (1Y)

Calculated over the trailing 1-year period

0.20

2.44

-2.24

Sharpe Ratio (5Y)

Calculated over the trailing 5-year period

-0.54

0.84

-1.38

Sharpe Ratio (10Y)

Calculated over the trailing 10-year period

—

0.87

—

Sharpe Ratio (All Time)

Calculated using the full available price history

-0.54

0.89

-1.43

Drawdowns

DNA vs. VOO - Drawdown Comparison

The maximum DNA drawdown since its inception was -99.10%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for DNA and VOO.

Loading charts...

Drawdown Indicators

DNAVOODifference

Max Drawdown

Largest peak-to-trough decline

-99.10%

-33.99%

-65.11%

Max Drawdown (1Y)

Largest decline over 1 year

-66.05%

-8.90%

-57.15%

Max Drawdown (3Y)

Largest decline over 3 years

-94.72%

-18.69%

-76.03%

Max Drawdown (5Y)

Largest decline over 5 years

-99.10%

-24.52%

-74.58%

Max Drawdown (10Y)

Largest decline over 10 years

—

-33.99%

—

Current Drawdown

Current decline from peak

-98.48%

-0.32%

-98.16%

Average Drawdown

Average peak-to-trough decline

-79.67%

-3.69%

-75.98%

Ulcer Index

Depth and duration of drawdowns from previous peaks

38.36%

1.91%

+36.45%

Volatility

DNA vs. VOO - Volatility Comparison

Ginkgo Bioworks Holdings, Inc. (DNA) has a higher volatility of 24.48% compared to Vanguard S&P 500 ETF (VOO) at 2.78%. This indicates that DNA's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Loading charts...

Volatility by Period

DNAVOODifference

Volatility (1M)

Calculated over the trailing 1-month period

24.48%

2.78%

+21.70%

Volatility (6M)

Calculated over the trailing 6-month period

70.39%

8.90%

+61.49%

Volatility (1Y)

Calculated over the trailing 1-year period

98.82%

11.80%

+87.02%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

97.72%

16.81%

+80.91%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

96.46%

18.00%

+78.46%

Dividends

DNA vs. VOO - Dividend Comparison

DNA has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.02%.

PositionTTM20252024202320222021202020192018201720162015
DNA
Ginkgo Bioworks Holdings, Inc.		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
VOO
Vanguard S&P 500 ETF		1.02%1.13%1.24%1.46%1.69%1.25%1.54%1.88%2.06%1.78%2.02%2.10%

Frequently Asked Questions

DNA and VOO have a correlation of 0.43, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

DNA has higher volatility (24.48%) compared to VOO (2.78%). In terms of maximum drawdown, DNA dropped -99.10% vs VOO's -33.99%.

VOO currently has the higher Sharpe Ratio (2.44 vs 0.20), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.

Portfolio Optimizer

Find the right allocation for DNA and VOO

Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.

Open Portfolio Optimizer