CLNN vs. VOO

Last updated Jun 4, 2026

CLNN (Clene Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 5 years, CLNN returned -51.34%/yr vs 13.90%/yr for VOO. At a 0.16 correlation, their price movements are largely independent.

Performance

CLNN vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Clene Inc. (CLNN) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CLNN achieves a -1.87% return, which is significantly lower than VOO's 10.91% return.

CLNN

• 1D: -1.87%
• 1M: -28.80%
• YTD: -1.87%
• 6M: -20.22%
• 1Y: 46.94%
• 3Y*: -34.82%
• 5Y*: -51.34%
• 10Y*: —

VOO

• 1D: -0.70%
• 1M: 5.04%
• YTD: 10.91%
• 6M: 10.93%
• 1Y: 28.04%
• 3Y*: 22.44%
• 5Y*: 13.90%
• 10Y*: 15.56%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CLNN vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CLNN Clene Inc.	-1.87%	10.55%	-10.49%	-70.34%	-75.61%	-54.50%
VOO Vanguard S&P 500 ETF	10.91%	17.82%	24.98%	26.32%	-18.17%	28.79%

Correlation

The correlation between CLNN and VOO is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.25
Correlation (3Y) Calculated over the trailing 3-year period	0.17
Correlation (5Y) Calculated over the trailing 5-year period	0.16
Correlation (All Time) Calculated using the full available price history since Jan 4, 2021	0.16

Return for Risk

CLNN vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CLNN

CLNN Risk / Return Rank: 58
CLNN Sharpe Ratio Rank: 56
CLNN Sortino Ratio Rank: 64
CLNN Omega Ratio Rank: 63
CLNN Calmar Ratio Rank: 56
CLNN Martin Ratio Rank: 53

VOO

VOO Risk / Return Rank: 70
VOO Sharpe Ratio Rank: 71
VOO Sortino Ratio Rank: 70
VOO Omega Ratio Rank: 70
VOO Calmar Ratio Rank: 62
VOO Martin Ratio Rank: 75

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CLNN vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Clene Inc. (CLNN) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CLNN	VOO	Difference
Sharpe ratio: Return per unit of total volatility	0.43	2.39	-1.96
Sortino ratio: Return per unit of downside risk	1.43	3.25	-1.83
Omega ratio: Gain probability vs. loss probability	1.18	1.43	-0.25
Calmar ratio: Return relative to maximum drawdown	0.69	3.16	-2.48
Martin ratio: Return relative to average drawdown	1.18	14.73	-13.54
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CLNN vs. VOO - Sharpe Ratio Comparison

The current CLNN Sharpe Ratio is 0.43, which is lower than the VOO Sharpe Ratio of 2.39. The chart below compares the historical Sharpe Ratios of CLNN and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CLNN	VOO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.43	2.39	-1.96
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.50	0.83	-1.33
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.87	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.42	0.89	-1.31

Drawdowns

CLNN vs. VOO - Drawdown Comparison

The maximum CLNN drawdown since its inception was -99.27%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for CLNN and VOO.

Drawdown Indicators

	CLNN	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-99.27%	-33.99%	-65.28%
Max Drawdown (1Y) Largest decline over 1 year	-68.64%	-8.90%	-59.74%
Max Drawdown (3Y) Largest decline over 3 years	-89.13%	-18.69%	-70.44%
Max Drawdown (5Y) Largest decline over 5 years	-99.13%	-24.52%	-74.61%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-98.23%	-0.70%	-97.53%
Average Drawdown Average peak-to-trough decline	-84.68%	-3.69%	-80.99%
Ulcer Index Depth and duration of drawdowns from previous peaks	39.77%	1.91%	+37.86%

Volatility

CLNN vs. VOO - Volatility Comparison

Clene Inc. (CLNN) has a higher volatility of 30.10% compared to Vanguard S&P 500 ETF (VOO) at 2.84%. This indicates that CLNN's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CLNN	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	30.10%	2.84%	+27.26%
Volatility (6M) Calculated over the trailing 6-month period	75.50%	8.90%	+66.60%
Volatility (1Y) Calculated over the trailing 1-year period	111.80%	11.80%	+100.00%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	103.31%	16.81%	+86.50%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	112.76%	18.01%	+94.75%

Dividends

CLNN vs. VOO - Dividend Comparison

CLNN has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.03%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CLNN Clene Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.03%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both CLNN and VOO in my portfolio?

CLNN and VOO have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CLNN or VOO?

CLNN has higher volatility (30.10%) compared to VOO (2.84%). In terms of maximum drawdown, CLNN dropped -99.27% vs VOO's -33.99%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.39 vs 0.43), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.