CDNA vs. XBI

Last updated Jun 24, 2026

CDNA (CareDx, Inc) is a stock, while XBI (SPDR S&P Biotech ETF) is Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index. Over the past 10 years, CDNA returned 18.12%/yr vs 11.14%/yr for XBI. At a 0.43 correlation, their price movements are largely independent.

Performance

CDNA vs. XBI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in CareDx, Inc (CDNA) and SPDR S&P Biotech ETF (XBI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CDNA achieves a 33.33% return, which is significantly higher than XBI's 20.70% return. Over the past 10 years, CDNA has outperformed XBI with an annualized return of 18.12%, while XBI has yielded a comparatively lower 11.14% annualized return.

CDNA

• 1D: 0.28%
• 1M: 16.13%
• YTD: 33.33%
• 6M: 25.47%
• 1Y: 32.56%
• 3Y*: 47.17%
• 5Y*: -23.31%
• 10Y*: 18.12%

XBI

• 1D: 0.80%
• 1M: 11.78%
• YTD: 20.70%
• 6M: 17.84%
• 1Y: 79.53%
• 3Y*: 20.24%
• 5Y*: 1.51%
• 10Y*: 11.14%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CDNA vs. XBI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CDNA CareDx, Inc	33.33%	-12.00%	78.42%	5.17%	-74.91%	-37.23%	235.88%	-14.20%	242.51%	171.85%
XBI SPDR S&P Biotech ETF	20.70%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%

Correlation

The correlation between CDNA and XBI is 0.39, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.39
Correlation (3Y) Calculated over the trailing 3-year period	0.49
Correlation (5Y) Calculated over the trailing 5-year period	0.59
Correlation (10Y) Calculated over the trailing 10-year period	0.50
Correlation (All Time) Calculated using the full available price history since Jul 17, 2014	0.43

The correlation between CDNA and XBI shifts across timeframes, from 0.39 (1 year) to 0.59 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

CDNA vs. XBI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CDNA

CDNA Risk / Return Rank: 60
CDNA Sharpe Ratio Rank: 58
CDNA Sortino Ratio Rank: 58
CDNA Omega Ratio Rank: 63
CDNA Calmar Ratio Rank: 59
CDNA Martin Ratio Rank: 59

XBI

XBI Risk / Return Rank: 90
XBI Sharpe Ratio Rank: 91
XBI Sortino Ratio Rank: 89
XBI Omega Ratio Rank: 82
XBI Calmar Ratio Rank: 96
XBI Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CDNA vs. XBI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for CareDx, Inc (CDNA) and SPDR S&P Biotech ETF (XBI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CDNA	XBI	Difference
Sharpe ratio: Return per unit of total volatility	0.45	3.02	-2.57
Sortino ratio: Return per unit of downside risk	1.10	3.89	-2.79
Omega ratio: Gain probability vs. loss probability	1.18	1.47	-0.29
Calmar ratio: Return relative to maximum drawdown	0.74	8.22	-7.48
Martin ratio: Return relative to average drawdown	1.55	24.30	-22.75

CDNA vs. XBI - Sharpe Ratio Comparison

The current CDNA Sharpe Ratio is 0.45, which is lower than the XBI Sharpe Ratio of 3.02. The chart below compares the historical Sharpe Ratios of CDNA and XBI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CDNA vs. XBI - Drawdown Comparison

The maximum CDNA drawdown since its inception was -94.87%, which is greater than XBI's maximum drawdown of -63.89%. Use the drawdown chart below to compare losses from any high point for CDNA and XBI.

Drawdown Indicators

	CDNA	XBI	Difference
Max Drawdown Largest peak-to-trough decline	-94.87%	-63.89%	-30.98%
Max Drawdown (1Y) Largest decline over 1 year	-43.92%	-9.72%	-34.20%
Max Drawdown (3Y) Largest decline over 3 years	-65.96%	-32.99%	-32.97%
Max Drawdown (5Y) Largest decline over 5 years	-94.85%	-54.71%	-40.14%
Max Drawdown (10Y) Largest decline over 10 years	-94.87%	-63.89%	-30.98%
Current Drawdown Current decline from peak	-73.72%	-14.94%	-58.78%
Average Drawdown Average peak-to-trough decline	-53.76%	-20.93%	-32.83%
Ulcer Index Depth and duration of drawdowns from previous peaks	21.10%	3.28%	+17.82%

Volatility

CDNA vs. XBI - Volatility Comparison

CareDx, Inc (CDNA) has a higher volatility of 16.19% compared to SPDR S&P Biotech ETF (XBI) at 9.96%. This indicates that CDNA's price experiences larger fluctuations and is considered to be riskier than XBI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CDNA	XBI	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.19%	9.96%	+6.23%
Volatility (6M) Calculated over the trailing 6-month period	45.85%	21.31%	+24.54%
Volatility (1Y) Calculated over the trailing 1-year period	72.20%	26.47%	+45.73%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	77.48%	32.30%	+45.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.19%	32.01%	+46.18%

Dividends

CDNA vs. XBI - Dividend Comparison

CDNA has not paid dividends to shareholders, while XBI's dividend yield for the trailing twelve months is around 0.39%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CDNA CareDx, Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.39%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both CDNA and XBI in my portfolio?

CDNA and XBI have a correlation of 0.39, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CDNA or XBI?

CDNA has higher volatility (16.19%) compared to XBI (9.96%). In terms of maximum drawdown, CDNA dropped -94.87% vs XBI's -63.89%.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (3.02 vs 0.45), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.