CDNA vs. SPY

Last updated Aug 1, 2026

CDNA (CareDx, Inc) is a stock, while SPY (State Street SPDR S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, CDNA returned 25.04%/yr vs 15.07%/yr for SPY. Their 0.33 correlation means their historical movements had little consistent relationship.

Performance

CDNA vs. SPY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in CareDx, Inc (CDNA) and State Street SPDR S&P 500 ETF (SPY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CDNA achieves a 132.01% return, which is significantly higher than SPY's 10.13% return. Over the past 10 years, CDNA has outperformed SPY with an annualized return of 25.04%, while SPY has yielded a comparatively lower 15.07% annualized return.

CDNA

• 1D: 14.72%
• 1M: 49.74%
• 6M: 112.70%
• YTD: 132.01%
• 1Y: 257.69%
• 3Y*: 60.92%
• 5Y*: -12.26%
• 10Y*: 25.04%
• ALL TIME*: 13.52%

SPY

• 1D: 0.72%
• 1M: 0.30%
• 6M: 8.53%
• YTD: 10.13%
• 1Y: 21.49%
• 3Y*: 19.32%
• 5Y*: 12.76%
• 10Y*: 15.07%
• ALL TIME*: 10.79%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
CDNA CareDx, Inc	$44.41M	$43.11M	$27.26M
SPY State Street SPDR S&P 500 ETF	$37.27B	$35.99B	$39.23B

CDNA vs. SPY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CDNA CareDx, Inc	132.01%	-12.00%	78.42%	5.17%	-74.91%	-37.23%	235.88%	-14.20%	242.51%	171.85%
SPY State Street SPDR S&P 500 ETF	10.13%	17.72%	24.89%	26.18%	-18.18%	28.73%	18.33%	31.22%	-4.57%	21.71%

Correlation

The correlation between CDNA and SPY is 0.31, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.31
Correlation (3Y) Balances recent behavior with more history.	0.38
Correlation (5Y) Shows whether the relationship held over a longer period.	0.44
Correlation (10Y) Provides a long-term view across more market conditions.	0.38
Correlation (All Time) Calculated using the full available price history since Jul 17, 2014	0.33

The correlation between CDNA and SPY shifts across timeframes, from 0.31 (1 year) to 0.44 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

CDNA vs. SPY — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

CDNA

CDNA Risk / Return Rank: 98
CDNA Sharpe Ratio Rank: 98
CDNA Sortino Ratio Rank: 98
CDNA Omega Ratio Rank: 97
CDNA Calmar Ratio Rank: 99
CDNA Martin Ratio Rank: 99

SPY

SPY Risk / Return Rank: 67
SPY Sharpe Ratio Rank: 67
SPY Sortino Ratio Rank: 64
SPY Omega Ratio Rank: 65
SPY Calmar Ratio Rank: 64
SPY Martin Ratio Rank: 76

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

CDNA vs. SPY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for CareDx, Inc (CDNA) and State Street SPDR S&P 500 ETF (SPY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CDNA	SPY	Difference
Sharpe ratio: Return per unit of total volatility	3.58	1.52	+2.06
Sortino ratio: Return per unit of downside risk	4.60	2.11	+2.48
Omega ratio: Gain probability vs. loss probability	1.54	1.27	+0.27
Calmar ratio: Return relative to maximum drawdown	10.90	2.20	+8.69
Martin ratio: Return relative to average drawdown	32.58	9.40	+23.18

CDNA vs. SPY - Sharpe Ratio Comparison

The current CDNA Sharpe Ratio is 3.58, which is higher than the SPY Sharpe Ratio of 1.52. The chart below compares the historical Sharpe Ratios of CDNA and SPY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CDNA vs. SPY - Drawdown Comparison

The maximum CDNA drawdown since its inception was -94.87%, which is greater than SPY's maximum drawdown of -55.19%. Use the drawdown chart below to compare losses from any high point for CDNA and SPY.

Drawdown Indicators

	CDNA	SPY	Difference
Max Drawdown Largest peak-to-trough decline	-94.87%	-55.19%	-39.68%
Max Drawdown (1Y) Largest decline over 1 year	-23.64%	-8.88%	-14.76%
Max Drawdown (3Y) Largest decline over 3 years	-65.96%	-18.76%	-47.20%
Max Drawdown (5Y) Largest decline over 5 years	-94.19%	-24.50%	-69.69%
Max Drawdown (10Y) Largest decline over 10 years	-94.87%	-33.72%	-61.15%
Current Drawdown Current decline from peak	-54.28%	-1.40%	-52.88%
Average Drawdown Average peak-to-trough decline	-53.87%	-9.01%	-44.86%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.89%	2.08%	+5.81%

Volatility

CDNA vs. SPY - Volatility Comparison

CareDx, Inc (CDNA) has a higher volatility of 35.19% compared to State Street SPDR S&P 500 ETF (SPY) at 3.58%. This indicates that CDNA's price experiences larger fluctuations and is considered to be riskier than SPY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CDNA	SPY	Difference
Volatility (1M) Calculated over the trailing 1-month period	35.19%	3.58%	+31.61%
Volatility (6M) Calculated over the trailing 6-month period	53.85%	10.14%	+43.71%
Volatility (1Y) Calculated over the trailing 1-year period	72.08%	12.89%	+59.19%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	79.44%	17.18%	+62.26%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	79.08%	17.95%	+61.13%

Dividends

CDNA vs. SPY - Dividend Comparison

CDNA has not paid dividends to shareholders, while SPY's dividend yield for the trailing twelve months is around 1.01%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CDNA CareDx, Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SPY State Street SPDR S&P 500 ETF	1.01%	1.07%	1.21%	1.40%	1.65%	1.20%	1.52%	1.75%	2.04%	1.80%	2.03%	2.06%

Frequently Asked Questions

Can I hold both CDNA and SPY in my portfolio?

CDNA and SPY have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CDNA or SPY?

CDNA has higher volatility (35.19%) compared to SPY (3.58%). In terms of maximum drawdown, CDNA dropped -94.87% vs SPY's -55.19%.

Which has better risk-adjusted returns?

CDNA currently has the higher Sharpe Ratio (3.58 vs 1.52), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.