ATXI vs. CRON

Last updated Jun 6, 2026

ATXI (Avenue Therapeutics, Inc.) and CRON (Cronos Group Inc.) are both stocks. Both are in the Healthcare sector — ATXI in Biotechnology, CRON in Drug Manufacturers - Specialty & Generic. Over the past 5 years, ATXI returned -85.32%/yr vs -20.47%/yr for CRON. At a 0.10 correlation, their price movements are largely independent.

Performance

ATXI vs. CRON - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Avenue Therapeutics, Inc. (ATXI) and Cronos Group Inc. (CRON). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ATXI achieves a -48.18% return, which is significantly lower than CRON's 4.18% return.

ATXI

• 1D: -0.25%
• 1M: -35.93%
• YTD: -48.18%
• 6M: -54.16%
• 1Y: 41.00%
• 3Y*: -83.87%
• 5Y*: -85.32%
• 10Y*: —

CRON

• 1D: -2.14%
• 1M: 4.58%
• YTD: 4.18%
• 6M: 10.04%
• 1Y: 43.46%
• 3Y*: 16.12%
• 5Y*: -20.47%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ATXI vs. CRON - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ATXI Avenue Therapeutics, Inc.	-48.18%	-65.99%	-83.44%	-86.12%	-91.48%	-84.74%	-38.02%	77.78%	49.17%	-56.12%
CRON Cronos Group Inc.	4.18%	30.20%	-3.35%	-17.72%	-35.20%	-43.52%	-9.52%	-26.18%	34.43%	477.19%

Correlation

The correlation between ATXI and CRON is -0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.07
Correlation (3Y) Calculated over the trailing 3-year period	0.04
Correlation (5Y) Calculated over the trailing 5-year period	0.11
Correlation (All Time) Calculated using the full available price history since Jun 28, 2017	0.10

The correlation between ATXI and CRON shifts across timeframes, from -0.07 (1 year) to 0.11 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

EPS ATXI : -$0.55 CRON : -$0.01
PS Ratio ATXI : 0.80 CRON : 3.60
Total Revenue (TTM) ATXI : $1.40M CRON : $220.07M
Gross Profit (TTM) ATXI : $0.00 CRON : $68.18M
EBITDA (TTM) ATXI : -$2.06M CRON : $2.28M

Return for Risk

ATXI vs. CRON — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ATXI

ATXI Risk / Return Rank: 62
ATXI Sharpe Ratio Rank: 49
ATXI Sortino Ratio Rank: 77
ATXI Omega Ratio Rank: 80
ATXI Calmar Ratio Rank: 53
ATXI Martin Ratio Rank: 52

CRON

CRON Risk / Return Rank: 69
CRON Sharpe Ratio Rank: 70
CRON Sortino Ratio Rank: 70
CRON Omega Ratio Rank: 66
CRON Calmar Ratio Rank: 70
CRON Martin Ratio Rank: 66

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ATXI vs. CRON - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Avenue Therapeutics, Inc. (ATXI) and Cronos Group Inc. (CRON). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ATXI	CRON	Difference
Sharpe ratio: Return per unit of total volatility	0.18	0.94	-0.76
Sortino ratio: Return per unit of downside risk	2.13	1.74	+0.39
Omega ratio: Gain probability vs. loss probability	1.31	1.20	+0.10
Calmar ratio: Return relative to maximum drawdown	0.49	1.62	-1.13
Martin ratio: Return relative to average drawdown	0.96	2.87	-1.91
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ATXI vs. CRON - Sharpe Ratio Comparison

The current ATXI Sharpe Ratio is 0.18, which is lower than the CRON Sharpe Ratio of 0.94. The chart below compares the historical Sharpe Ratios of ATXI and CRON, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ATXI	CRON	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.18	0.94	-0.76
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.47	-0.38	-0.09
Sharpe Ratio (All Time) Calculated using the full available price history	-0.47	0.44	-0.91

Drawdowns

ATXI vs. CRON - Drawdown Comparison

The maximum ATXI drawdown since its inception was -100.00%, which is greater than CRON's maximum drawdown of -93.16%. Use the drawdown chart below to compare losses from any high point for ATXI and CRON.

Drawdown Indicators

	ATXI	CRON	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-93.16%	-6.84%
Max Drawdown (1Y) Largest decline over 1 year	-83.80%	-26.91%	-56.89%
Max Drawdown (3Y) Largest decline over 3 years	-99.83%	-46.36%	-53.47%
Max Drawdown (5Y) Largest decline over 5 years	-100.00%	-82.12%	-17.88%
Current Drawdown Current decline from peak	-100.00%	-88.44%	-11.56%
Average Drawdown Average peak-to-trough decline	-70.69%	-63.58%	-7.11%
Ulcer Index Depth and duration of drawdowns from previous peaks	42.77%	15.17%	+27.60%

Volatility

ATXI vs. CRON - Volatility Comparison

Avenue Therapeutics, Inc. (ATXI) has a higher volatility of 70.81% compared to Cronos Group Inc. (CRON) at 12.26%. This indicates that ATXI's price experiences larger fluctuations and is considered to be riskier than CRON based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ATXI	CRON	Difference
Volatility (1M) Calculated over the trailing 1-month period	70.81%	12.26%	+58.55%
Volatility (6M) Calculated over the trailing 6-month period	164.32%	31.33%	+132.99%
Volatility (1Y) Calculated over the trailing 1-year period	233.31%	46.50%	+186.81%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	179.97%	53.92%	+126.05%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	145.49%	74.71%	+70.78%

Dividends

ATXI vs. CRON - Dividend Comparison

Neither ATXI nor CRON has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ATXI and CRON in my portfolio?

ATXI and CRON have a correlation of -0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ATXI or CRON?

ATXI has higher volatility (70.81%) compared to CRON (12.26%). In terms of maximum drawdown, ATXI dropped -100.00% vs CRON's -93.16%.

Which has better risk-adjusted returns?

CRON currently has the higher Sharpe Ratio (0.94 vs 0.18), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.