ARVN vs. KYMR

Last updated Jun 27, 2026

ARVN (Arvinas, Inc.) and KYMR (Kymera Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, ARVN returned -36.29%/yr vs 19.49%/yr for KYMR. At a 0.48 correlation, their price movements are largely independent.

Performance

ARVN vs. KYMR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Arvinas, Inc. (ARVN) and Kymera Therapeutics, Inc. (KYMR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ARVN achieves a -32.55% return, which is significantly lower than KYMR's 38.95% return.

ARVN

• 1D: -0.37%
• 1M: -9.60%
• YTD: -32.55%
• 6M: -34.21%
• 1Y: 2.56%
• 3Y*: -33.34%
• 5Y*: -36.29%
• 10Y*: —

KYMR

• 1D: -7.16%
• 1M: 32.34%
• YTD: 38.95%
• 6M: 32.96%
• 1Y: 136.53%
• 3Y*: 68.43%
• 5Y*: 19.49%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ARVN vs. KYMR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
ARVN Arvinas, Inc.	-32.55%	-38.13%	-53.43%	20.32%	-58.35%	-3.29%	227.92%
KYMR Kymera Therapeutics, Inc.	38.95%	93.41%	58.01%	2.00%	-60.69%	2.40%	77.14%

Correlation

The correlation between ARVN and KYMR is 0.40, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.40
Correlation (3Y) Calculated over the trailing 3-year period	0.46
Correlation (5Y) Calculated over the trailing 5-year period	0.51
Correlation (All Time) Calculated using the full available price history since Aug 21, 2020	0.48

The correlation between ARVN and KYMR shifts across timeframes, from 0.40 (1 year) to 0.51 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ARVN : $512.00M KYMR : $10.55B
EPS ARVN : -$3.22 KYMR : -$3.60
PS Ratio ARVN : 6.15 KYMR : 183.65
PB Ratio ARVN : 1.32 KYMR : 6.85
Total Revenue (TTM) ARVN : $89.40M KYMR : $51.47M
Gross Profit (TTM) ARVN : $72.60M KYMR : $17.10M
EBITDA (TTM) ARVN : -$233.90M KYMR : -$323.05M

Return for Risk

ARVN vs. KYMR — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ARVN

ARVN Risk / Return Rank: 44
ARVN Sharpe Ratio Rank: 45
ARVN Sortino Ratio Rank: 44
ARVN Omega Ratio Rank: 43
ARVN Calmar Ratio Rank: 45
ARVN Martin Ratio Rank: 45

KYMR

KYMR Risk / Return Rank: 92
KYMR Sharpe Ratio Rank: 91
KYMR Sortino Ratio Rank: 93
KYMR Omega Ratio Rank: 90
KYMR Calmar Ratio Rank: 93
KYMR Martin Ratio Rank: 91

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ARVN vs. KYMR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Arvinas, Inc. (ARVN) and Kymera Therapeutics, Inc. (KYMR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ARVN	KYMR	Difference
Sharpe ratio: Return per unit of total volatility	0.05	2.17	-2.12
Sortino ratio: Return per unit of downside risk	0.47	3.46	-2.98
Omega ratio: Gain probability vs. loss probability	1.06	1.40	-0.35
Calmar ratio: Return relative to maximum drawdown	0.05	4.95	-4.90
Martin ratio: Return relative to average drawdown	0.14	11.77	-11.63

ARVN vs. KYMR - Sharpe Ratio Comparison

The current ARVN Sharpe Ratio is 0.05, which is lower than the KYMR Sharpe Ratio of 2.17. The chart below compares the historical Sharpe Ratios of ARVN and KYMR, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ARVN vs. KYMR - Drawdown Comparison

The maximum ARVN drawdown since its inception was -94.37%, which is greater than KYMR's maximum drawdown of -87.51%. Use the drawdown chart below to compare losses from any high point for ARVN and KYMR.

Drawdown Indicators

	ARVN	KYMR	Difference
Max Drawdown Largest peak-to-trough decline	-94.37%	-87.51%	-6.86%
Max Drawdown (1Y) Largest decline over 1 year	-49.53%	-27.74%	-21.79%
Max Drawdown (3Y) Largest decline over 3 years	-88.40%	-59.83%	-28.57%
Max Drawdown (5Y) Largest decline over 5 years	-94.37%	-83.54%	-10.83%
Current Drawdown Current decline from peak	-92.58%	-7.16%	-85.42%
Average Drawdown Average peak-to-trough decline	-52.21%	-49.12%	-3.09%
Ulcer Index Depth and duration of drawdowns from previous peaks	18.47%	11.66%	+6.81%

Volatility

ARVN vs. KYMR - Volatility Comparison

The current volatility for Arvinas, Inc. (ARVN) is 14.96%, while Kymera Therapeutics, Inc. (KYMR) has a volatility of 23.95%. This indicates that ARVN experiences smaller price fluctuations and is considered to be less risky than KYMR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ARVN	KYMR	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.96%	23.95%	-8.99%
Volatility (6M) Calculated over the trailing 6-month period	36.47%	35.61%	+0.86%
Volatility (1Y) Calculated over the trailing 1-year period	56.21%	63.47%	-7.26%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	68.86%	73.68%	-4.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.01%	75.58%	+2.43%

Dividends

ARVN vs. KYMR - Dividend Comparison

Neither ARVN nor KYMR has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ARVN and KYMR in my portfolio?

ARVN and KYMR have a correlation of 0.40, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ARVN or KYMR?

KYMR has higher volatility (23.95%) compared to ARVN (14.96%). In terms of maximum drawdown, ARVN dropped -94.37% vs KYMR's -87.51%.

Which has better risk-adjusted returns?

KYMR currently has the higher Sharpe Ratio (2.17 vs 0.05), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.