AMPH vs. MA

Last updated Jun 4, 2026

AMPH (Amphastar Pharmaceuticals, Inc.) and MA (Mastercard Inc) are both stocks. AMPH operates in Drug Manufacturers - Specialty & Generic (Healthcare), while MA operates in Credit Services (Financial Services). Over the past 10 years, AMPH returned 1.39%/yr vs 17.95%/yr for MA. At a 0.26 correlation, their price movements are largely independent.

Performance

AMPH vs. MA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amphastar Pharmaceuticals, Inc. (AMPH) and Mastercard Inc (MA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AMPH achieves a -32.34% return, which is significantly lower than MA's -17.13% return. Over the past 10 years, AMPH has underperformed MA with an annualized return of 1.39%, while MA has yielded a comparatively higher 17.95% annualized return.

AMPH

• 1D: -1.79%
• 1M: -20.32%
• YTD: -32.34%
• 6M: -34.30%
• 1Y: -30.33%
• 3Y*: -27.06%
• 5Y*: -0.72%
• 10Y*: 1.39%

MA

• 1D: -1.28%
• 1M: -6.58%
• YTD: -17.13%
• 6M: -14.57%
• 1Y: -18.49%
• 3Y*: 8.69%
• 5Y*: 5.81%
• 10Y*: 17.95%

*Multi-year figures are annualized to reflect compound growth (CAGR)

AMPH vs. MA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AMPH Amphastar Pharmaceuticals, Inc.	-32.34%	-27.88%	-39.97%	120.74%	20.31%	15.81%	4.25%	-3.07%	3.43%	4.45%
MA Mastercard Inc	-17.13%	9.04%	24.17%	23.40%	-2.66%	1.16%	20.19%	59.16%	25.31%	47.69%

Correlation

The correlation between AMPH and MA is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.26
Correlation (3Y) Calculated over the trailing 3-year period	0.27
Correlation (5Y) Calculated over the trailing 5-year period	0.24
Correlation (10Y) Calculated over the trailing 10-year period	0.26
Correlation (All Time) Calculated using the full available price history since Jun 26, 2014	0.26

Fundamentals

Market Cap AMPH : $841.82M MA : $421.09B
EPS AMPH : $1.67 MA : $17.28
PE Ratio AMPH : 10.83 MA : 27.30
PEG Ratio AMPH : 0.57 MA : 1.59
PS Ratio AMPH : 1.19 MA : 12.52
PB Ratio AMPH : 1.09 MA : 62.64
Total Revenue (TTM) AMPH : $720.53M MA : $33.94B
Gross Profit (TTM) AMPH : $341.13M MA : $26.70B
EBITDA (TTM) AMPH : $155.96M MA : $21.23B

Return for Risk

AMPH vs. MA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AMPH

AMPH Risk / Return Rank: 15
AMPH Sharpe Ratio Rank: 16
AMPH Sortino Ratio Rank: 19
AMPH Omega Ratio Rank: 18
AMPH Calmar Ratio Rank: 16
AMPH Martin Ratio Rank: 8

MA

MA Risk / Return Rank: 7
MA Sharpe Ratio Rank: 8
MA Sortino Ratio Rank: 10
MA Omega Ratio Rank: 11
MA Calmar Ratio Rank: 6
MA Martin Ratio Rank: 1

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AMPH vs. MA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amphastar Pharmaceuticals, Inc. (AMPH) and Mastercard Inc (MA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AMPH	MA	Difference
Sharpe ratio Return per unit of total volatility	-0.57	-0.84	+0.27
Sortino ratio Return per unit of downside risk	-0.51	-1.07	+0.55
Omega ratio Gain probability vs. loss probability	0.92	0.87	+0.05
Calmar ratio Return relative to maximum drawdown	-0.67	-0.89	+0.21
Martin ratio Return relative to average drawdown	-1.39	-1.84	+0.45
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AMPH vs. MA - Sharpe Ratio Comparison

The current AMPH Sharpe Ratio is -0.57, which is higher than the MA Sharpe Ratio of -0.84. The chart below compares the historical Sharpe Ratios of AMPH and MA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AMPH	MA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.57	-0.84	+0.27
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.02	0.24	-0.26
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.03	0.67	-0.64
Sharpe Ratio (All Time) Calculated using the full available price history	0.15	0.83	-0.68

Drawdowns

AMPH vs. MA - Drawdown Comparison

The maximum AMPH drawdown since its inception was -74.05%, which is greater than MA's maximum drawdown of -62.67%. Use the drawdown chart below to compare losses from any high point for AMPH and MA.

Drawdown Indicators

	AMPH	MA	Difference
Max Drawdown Largest peak-to-trough decline	-74.05%	-62.67%	-11.38%
Max Drawdown (1Y) Largest decline over 1 year	-45.25%	-20.91%	-24.34%
Max Drawdown (3Y) Largest decline over 3 years	-74.05%	-20.91%	-53.14%
Max Drawdown (5Y) Largest decline over 5 years	-74.05%	-28.25%	-45.80%
Max Drawdown (10Y) Largest decline over 10 years	-74.05%	-41.00%	-33.05%
Current Drawdown Current decline from peak	-72.12%	-20.91%	-51.21%
Average Drawdown Average peak-to-trough decline	-23.98%	-9.82%	-14.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	21.90%	10.06%	+11.84%

Volatility

AMPH vs. MA - Volatility Comparison

Amphastar Pharmaceuticals, Inc. (AMPH) has a higher volatility of 26.71% compared to Mastercard Inc (MA) at 5.95%. This indicates that AMPH's price experiences larger fluctuations and is considered to be riskier than MA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AMPH	MA	Difference
Volatility (1M) Calculated over the trailing 1-month period	26.71%	5.95%	+20.76%
Volatility (6M) Calculated over the trailing 6-month period	45.74%	17.27%	+28.47%
Volatility (1Y) Calculated over the trailing 1-year period	53.42%	22.03%	+31.39%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	44.99%	23.96%	+21.03%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	42.65%	26.91%	+15.74%

Dividends

AMPH vs. MA - Dividend Comparison

AMPH has not paid dividends to shareholders, while MA's dividend yield for the trailing twelve months is around 0.69%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AMPH Amphastar Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
MA Mastercard Inc	0.69%	0.53%	0.50%	0.53%	0.56%	0.49%	0.45%	0.44%	0.53%	0.58%	0.74%	0.66%

Financials

AMPH vs. MA - Profitability Comparison

The chart below illustrates the profitability comparison between Amphastar Pharmaceuticals, Inc. and Mastercard Inc over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

AMPH - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Amphastar Pharmaceuticals, Inc. reported a gross profit of 70.32M and revenue of 171.17M. Therefore, the gross margin over that period was 41.1%.

MA - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Mastercard Inc reported a gross profit of 4.91B and revenue of 8.40B. Therefore, the gross margin over that period was 58.4%.

AMPH - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Amphastar Pharmaceuticals, Inc. reported an operating income of 13.63M and revenue of 171.17M, resulting in an operating margin of 8.0%.

MA - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Mastercard Inc reported an operating income of 4.91B and revenue of 8.40B, resulting in an operating margin of 58.4%.

AMPH - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Amphastar Pharmaceuticals, Inc. reported a net income of 6.42M and revenue of 171.17M, resulting in a net margin of 3.8%.

MA - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Mastercard Inc reported a net income of 3.88B and revenue of 8.40B, resulting in a net margin of 46.2%.

Frequently Asked Questions

Can I hold both AMPH and MA in my portfolio?

AMPH and MA have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AMPH or MA?

AMPH has higher volatility (26.71%) compared to MA (5.95%). In terms of maximum drawdown, AMPH dropped -74.05% vs MA's -62.67%.

Which has better risk-adjusted returns?

AMPH currently has the higher Sharpe Ratio (-0.57 vs -0.84), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.