AGIO vs. PFE
AGIO (Agios Pharmaceuticals, Inc.) and PFE (Pfizer Inc.) are both stocks. Both are in the Healthcare sector — AGIO in Biotechnology, PFE in Drug Manufacturers - General. Over the past 10 years, AGIO returned -6.94%/yr vs 1.85%/yr for PFE. At a 0.25 correlation, their price movements are largely independent.
Performance
AGIO vs. PFE - Performance Comparison
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Returns By Period
In the year-to-date period, AGIO achieves a 1.69% return, which is significantly lower than PFE's 5.18% return. Over the past 10 years, AGIO has underperformed PFE with an annualized return of -6.94%, while PFE has yielded a comparatively higher 1.85% annualized return.
AGIO
- 1D
- 4.41%
- 1M
- 0.44%
- YTD
- 1.69%
- 6M
- 0.69%
- 1Y
- -17.05%
- 3Y*
- 2.04%
- 5Y*
- -13.63%
- 10Y*
- -6.94%
PFE
- 1D
- -0.82%
- 1M
- -2.06%
- YTD
- 5.18%
- 6M
- 2.42%
- 1Y
- 16.11%
- 3Y*
- -7.32%
- 5Y*
- -3.51%
- 10Y*
- 1.85%
AGIO vs. PFE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
AGIO Agios Pharmaceuticals, Inc. | 1.69% | -17.16% | 47.55% | -20.69% | -14.57% | -24.14% | -9.26% | 3.56% | -19.35% | 37.00% |
PFE Pfizer Inc. | 5.18% | 0.65% | -2.22% | -41.26% | -10.41% | 66.70% | 3.07% | -6.91% | 24.82% | 15.90% |
Correlation
The correlation between AGIO and PFE is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.24 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.24 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.22 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.24 |
Correlation (All Time) Calculated using the full available price history since Jul 25, 2013 | 0.25 |
Fundamentals
AGIO:
$1.63B
PFE:
$145.22B
AGIO:
-$7.25
PFE:
$1.31
AGIO:
24.43
PFE:
2.28
AGIO:
1.47
PFE:
1.61
AGIO:
$66.05M
PFE:
$63.32B
AGIO:
$59.47M
PFE:
$43.91B
AGIO:
-$443.16M
PFE:
$16.94B
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Return for Risk
AGIO vs. PFE — Risk / Return Rank
AGIO
PFE
AGIO vs. PFE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Agios Pharmaceuticals, Inc. (AGIO) and Pfizer Inc. (PFE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| AGIO | PFE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.91 | ||
| Sortino ratioReturn per unit of downside risk | -0.91 | ||
| Omega ratioGain probability vs. loss probability | 1.06 | 1.14 | -0.08 |
| Calmar ratioReturn relative to maximum drawdown | -0.34 | 1.41 | -1.75 |
| Martin ratioReturn relative to average drawdown | -0.61 | 2.91 | -3.52 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| AGIO | PFE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.23 | 0.68 | -0.91 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.23 | -0.14 | -0.09 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.12 | 0.08 | -0.20 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.01 | 0.23 | -0.25 |
Drawdowns
AGIO vs. PFE - Drawdown Comparison
The maximum AGIO drawdown since its inception was -87.36%, which is greater than PFE's maximum drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for AGIO and PFE.
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Drawdown Indicators
| AGIO | PFE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -87.36% | -58.96% | -28.40% |
Max Drawdown (1Y)Largest decline over 1 year | -50.89% | -11.47% | -39.42% |
Max Drawdown (3Y)Largest decline over 3 years | -63.76% | -40.75% | -23.01% |
Max Drawdown (5Y)Largest decline over 5 years | -72.16% | -58.96% | -13.20% |
Max Drawdown (10Y)Largest decline over 10 years | -82.86% | -58.96% | -23.90% |
Current DrawdownCurrent decline from peak | -79.50% | -47.49% | -32.01% |
Average DrawdownAverage peak-to-trough decline | -58.83% | -17.68% | -41.15% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 28.03% | 5.54% | +22.49% |
Volatility
AGIO vs. PFE - Volatility Comparison
Agios Pharmaceuticals, Inc. (AGIO) has a higher volatility of 12.75% compared to Pfizer Inc. (PFE) at 4.07%. This indicates that AGIO's price experiences larger fluctuations and is considered to be riskier than PFE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| AGIO | PFE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 12.75% | 4.07% | +8.68% |
Volatility (6M)Calculated over the trailing 6-month period | 43.78% | 14.64% | +29.14% |
Volatility (1Y)Calculated over the trailing 1-year period | 74.57% | 23.85% | +50.72% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 58.80% | 25.49% | +33.31% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 57.23% | 23.88% | +33.35% |
Dividends
AGIO vs. PFE - Dividend Comparison
AGIO has not paid dividends to shareholders, while PFE's dividend yield for the trailing twelve months is around 6.79%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AGIO Agios Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
PFE Pfizer Inc. | 6.79% | 6.91% | 6.33% | 5.70% | 3.12% | 2.64% | 3.92% | 3.68% | 3.12% | 3.53% | 3.69% | 3.47% |
Financials
AGIO vs. PFE - Financials Comparison
This section allows you to compare key financial metrics between Agios Pharmaceuticals, Inc. and Pfizer Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
AGIO and PFE have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
AGIO has higher volatility (12.75%) compared to PFE (4.07%). In terms of maximum drawdown, AGIO dropped -87.36% vs PFE's -58.96%.
PFE currently has the higher Sharpe Ratio (0.68 vs -0.23), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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