AGIO vs. PFE
Compare and contrast key facts about Agios Pharmaceuticals, Inc. (AGIO) and Pfizer Inc. (PFE).
Performance
AGIO vs. PFE - Performance Comparison
Loading graphics...
AGIO vs. PFE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
AGIO Agios Pharmaceuticals, Inc. | 24.28% | -17.16% | 47.55% | -20.69% | -14.57% | -24.14% | -9.26% | 3.56% | -19.35% | 37.00% |
PFE Pfizer Inc. | 14.66% | 0.65% | -2.22% | -41.26% | -10.41% | 66.70% | 3.07% | -6.91% | 24.82% | 15.90% |
Fundamentals
AGIO:
$1.97B
PFE:
$159.66B
AGIO:
-$7.10
PFE:
$1.36
AGIO:
36.41
PFE:
2.56
AGIO:
1.65
PFE:
1.72
AGIO:
$54.03M
PFE:
$62.58B
AGIO:
$47.68M
PFE:
$44.01B
AGIO:
-$438.48M
PFE:
$15.10B
Returns By Period
In the year-to-date period, AGIO achieves a 24.28% return, which is significantly higher than PFE's 14.66% return. Over the past 10 years, AGIO has underperformed PFE with an annualized return of -2.10%, while PFE has yielded a comparatively higher 4.32% annualized return.
AGIO
- 1D
- 14.25%
- 1M
- 11.91%
- YTD
- 24.28%
- 6M
- -15.72%
- 1Y
- 15.46%
- 3Y*
- 13.78%
- 5Y*
- -8.46%
- 10Y*
- -2.10%
PFE
- 1D
- 1.12%
- 1M
- 1.56%
- YTD
- 14.66%
- 6M
- 14.02%
- 1Y
- 18.86%
- 3Y*
- -6.22%
- 5Y*
- -0.14%
- 10Y*
- 4.32%
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
AGIO vs. PFE — Risk / Return Rank
AGIO
PFE
AGIO vs. PFE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Agios Pharmaceuticals, Inc. (AGIO) and Pfizer Inc. (PFE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| AGIO | PFE | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 0.22 | 0.71 | -0.49 |
Sortino ratioReturn per unit of downside risk | 0.80 | 1.17 | -0.37 |
Omega ratioGain probability vs. loss probability | 1.17 | 1.15 | +0.02 |
Calmar ratioReturn relative to maximum drawdown | 0.23 | 1.32 | -1.09 |
Martin ratioReturn relative to average drawdown | 0.49 | 3.18 | -2.68 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
Loading graphics...
Sharpe Ratios by Period
| AGIO | PFE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.22 | 0.71 | -0.49 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.15 | -0.01 | -0.14 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.04 | 0.18 | -0.22 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.01 | 0.26 | -0.25 |
Correlation
The correlation between AGIO and PFE is 0.25, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
AGIO vs. PFE - Dividend Comparison
AGIO has not paid dividends to shareholders, while PFE's dividend yield for the trailing twelve months is around 6.13%.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AGIO Agios Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
PFE Pfizer Inc. | 6.13% | 6.91% | 6.33% | 5.70% | 3.12% | 2.64% | 3.92% | 3.68% | 3.12% | 3.53% | 3.69% | 3.47% |
Drawdowns
AGIO vs. PFE - Drawdown Comparison
The maximum AGIO drawdown since its inception was -87.36%, which is greater than PFE's maximum drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for AGIO and PFE.
Loading graphics...
Drawdown Indicators
| AGIO | PFE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -87.36% | -58.96% | -28.40% |
Max Drawdown (1Y)Largest decline over 1 year | -50.89% | -12.59% | -38.30% |
Max Drawdown (5Y)Largest decline over 5 years | -72.16% | -58.96% | -13.20% |
Max Drawdown (10Y)Largest decline over 10 years | -82.86% | -58.96% | -23.90% |
Current DrawdownCurrent decline from peak | -74.94% | -42.75% | -32.19% |
Average DrawdownAverage peak-to-trough decline | -58.57% | -17.33% | -41.24% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 23.81% | 6.13% | +17.68% |
Volatility
AGIO vs. PFE - Volatility Comparison
Agios Pharmaceuticals, Inc. (AGIO) has a higher volatility of 15.97% compared to Pfizer Inc. (PFE) at 6.75%. This indicates that AGIO's price experiences larger fluctuations and is considered to be riskier than PFE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading graphics...
Volatility by Period
| AGIO | PFE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 15.97% | 6.75% | +9.22% |
Volatility (6M)Calculated over the trailing 6-month period | 79.70% | 18.50% | +61.20% |
Volatility (1Y)Calculated over the trailing 1-year period | 71.09% | 26.73% | +44.36% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 57.37% | 25.46% | +31.91% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 57.32% | 23.90% | +33.42% |
Financials
AGIO vs. PFE - Financials Comparison
This section allows you to compare key financial metrics between Agios Pharmaceuticals, Inc. and Pfizer Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities