UTHR vs. AUTL

Last updated Jun 9, 2026

UTHR (United Therapeutics Corporation) and AUTL (Autolus Therapeutics plc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, UTHR returned 25.53%/yr vs -26.36%/yr for AUTL. At a 0.13 correlation, their price movements are largely independent.

Performance

UTHR vs. AUTL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in United Therapeutics Corporation (UTHR) and Autolus Therapeutics plc (AUTL). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, UTHR achieves a 11.79% return, which is significantly higher than AUTL's -26.63% return.

UTHR

• 1D: -0.94%
• 1M: -3.58%
• YTD: 11.79%
• 6M: 13.59%
• 1Y: 67.18%
• 3Y*: 33.59%
• 5Y*: 25.53%
• 10Y*: 17.20%

AUTL

• 1D: -4.58%
• 1M: -7.01%
• YTD: -26.63%
• 6M: -8.18%
• 1Y: -37.61%
• 3Y*: -20.17%
• 5Y*: -26.36%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

UTHR vs. AUTL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
UTHR United Therapeutics Corporation	11.79%	38.09%	60.46%	-20.93%	28.70%	42.35%	72.33%	-19.12%	-6.71%
AUTL Autolus Therapeutics plc	-26.63%	-15.32%	-63.51%	238.95%	-63.39%	-41.95%	-32.27%	-59.81%	17.29%

Correlation

The correlation between UTHR and AUTL is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.14
Correlation (3Y) Calculated over the trailing 3-year period	0.12
Correlation (5Y) Calculated over the trailing 5-year period	0.11
Correlation (All Time) Calculated using the full available price history since Jun 22, 2018	0.13

Fundamentals

Market Cap UTHR : $25.71B AUTL : $388.57M
EPS UTHR : $27.00 AUTL : -$1.09
PS Ratio UTHR : 8.19 AUTL : 4.20
PB Ratio UTHR : 4.36 AUTL : 3.57
Total Revenue (TTM) UTHR : $3.17B AUTL : $92.59M
Gross Profit (TTM) UTHR : $2.74B AUTL : -$10.36M
EBITDA (TTM) UTHR : $1.75B AUTL : -$253.48M

Return for Risk

UTHR vs. AUTL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

UTHR

UTHR Risk / Return Rank: 86
UTHR Sharpe Ratio Rank: 80
UTHR Sortino Ratio Rank: 87
UTHR Omega Ratio Rank: 87
UTHR Calmar Ratio Rank: 89
UTHR Martin Ratio Rank: 89

AUTL

AUTL Risk / Return Rank: 22
AUTL Sharpe Ratio Rank: 20
AUTL Sortino Ratio Rank: 23
AUTL Omega Ratio Rank: 24
AUTL Calmar Ratio Rank: 16
AUTL Martin Ratio Rank: 23

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

UTHR vs. AUTL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for United Therapeutics Corporation (UTHR) and Autolus Therapeutics plc (AUTL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	UTHR	AUTL	Difference
Sharpe ratio: Return per unit of total volatility	1.36	-0.50	+1.86
Sortino ratio: Return per unit of downside risk	2.76	-0.37	+3.13
Omega ratio: Gain probability vs. loss probability	1.37	0.96	+0.42
Calmar ratio: Return relative to maximum drawdown	4.13	-0.69	+4.82
Martin ratio: Return relative to average drawdown	10.54	-0.96	+11.51
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

UTHR vs. AUTL - Sharpe Ratio Comparison

The current UTHR Sharpe Ratio is 1.36, which is higher than the AUTL Sharpe Ratio of -0.50. The chart below compares the historical Sharpe Ratios of UTHR and AUTL, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	UTHR	AUTL	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.36	-0.50	+1.86
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.73	-0.34	+1.07
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.49	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.38	-0.37	+0.75

Drawdowns

UTHR vs. AUTL - Drawdown Comparison

The maximum UTHR drawdown since its inception was -93.18%, roughly equal to the maximum AUTL drawdown of -97.63%. Use the drawdown chart below to compare losses from any high point for UTHR and AUTL.

Drawdown Indicators

	UTHR	AUTL	Difference
Max Drawdown Largest peak-to-trough decline	-93.18%	-97.63%	+4.45%
Max Drawdown (1Y) Largest decline over 1 year	-16.35%	-54.85%	+38.50%
Max Drawdown (3Y) Largest decline over 3 years	-33.00%	-84.36%	+51.36%
Max Drawdown (5Y) Largest decline over 5 years	-33.00%	-85.68%	+52.68%
Max Drawdown (10Y) Largest decline over 10 years	-55.56%	—	—
Current Drawdown Current decline from peak	-8.73%	-96.96%	+88.23%
Average Drawdown Average peak-to-trough decline	-35.31%	-81.27%	+45.96%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.39%	39.02%	-32.63%

Volatility

UTHR vs. AUTL - Volatility Comparison

The current volatility for United Therapeutics Corporation (UTHR) is 5.15%, while Autolus Therapeutics plc (AUTL) has a volatility of 24.19%. This indicates that UTHR experiences smaller price fluctuations and is considered to be less risky than AUTL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	UTHR	AUTL	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.15%	24.19%	-19.04%
Volatility (6M) Calculated over the trailing 6-month period	26.01%	52.08%	-26.07%
Volatility (1Y) Calculated over the trailing 1-year period	49.84%	75.46%	-25.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	35.13%	77.73%	-42.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	35.07%	80.85%	-45.78%

Dividends

UTHR vs. AUTL - Dividend Comparison

Neither UTHR nor AUTL has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both UTHR and AUTL in my portfolio?

UTHR and AUTL have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, UTHR or AUTL?

AUTL has higher volatility (24.19%) compared to UTHR (5.15%). In terms of maximum drawdown, UTHR dropped -93.18% vs AUTL's -97.63%.

Which has better risk-adjusted returns?

UTHR currently has the higher Sharpe Ratio (1.36 vs -0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.