MSTR vs. AMGN

Last updated Jun 9, 2026

MSTR (Strategy Inc) and AMGN (Amgen Inc.) are both stocks. MSTR operates in Software - Application (Technology), while AMGN operates in Drug Manufacturers - General (Healthcare). Over the past 10 years, MSTR returned 21.08%/yr vs 11.65%/yr for AMGN. At a 0.22 correlation, their price movements are largely independent.

Performance

MSTR vs. AMGN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Strategy Inc (MSTR) and Amgen Inc. (AMGN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MSTR achieves a -16.29% return, which is significantly lower than AMGN's 7.16% return. Over the past 10 years, MSTR has outperformed AMGN with an annualized return of 21.08%, while AMGN has yielded a comparatively lower 11.65% annualized return.

MSTR

• 1D: 5.61%
• 1M: -32.19%
• YTD: -16.29%
• 6M: -30.75%
• 1Y: -66.03%
• 3Y*: 65.16%
• 5Y*: 19.92%
• 10Y*: 21.08%

AMGN

• 1D: -1.10%
• 1M: 5.02%
• YTD: 7.16%
• 6M: 9.19%
• 1Y: 22.66%
• 3Y*: 20.11%
• 5Y*: 11.06%
• 10Y*: 11.65%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MSTR vs. AMGN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
MSTR Strategy Inc	-16.29%	-47.53%	358.54%	346.15%	-74.00%	40.13%	172.42%	11.65%	-2.70%	-33.49%
AMGN Amgen Inc.	7.16%	29.67%	-6.77%	13.46%	20.43%	0.87%	-1.99%	27.60%	15.23%	22.27%

Correlation

The correlation between MSTR and AMGN is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (5Y) Calculated over the trailing 5-year period	0.14
Correlation (10Y) Calculated over the trailing 10-year period	0.17
Correlation (All Time) Calculated using the full available price history since Jun 11, 1998	0.22

The correlation between MSTR and AMGN shifts across timeframes, from 0.12 (1 year) to 0.22 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap MSTR : $42.47B AMGN : $188.08B
EPS MSTR : -$40.19 AMGN : $14.38
PS Ratio MSTR : 79.74 AMGN : 5.04
PB Ratio MSTR : 1.16 AMGN : 20.47
Total Revenue (TTM) MSTR : $490.47M AMGN : $37.24B
Gross Profit (TTM) MSTR : $334.08M AMGN : $26.61B
EBITDA (TTM) MSTR : $466.93M AMGN : $17.27B

Return for Risk

MSTR vs. AMGN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MSTR

MSTR Risk / Return Rank: 8
MSTR Sharpe Ratio Rank: 6
MSTR Sortino Ratio Rank: 5
MSTR Omega Ratio Rank: 7
MSTR Calmar Ratio Rank: 8
MSTR Martin Ratio Rank: 13

AMGN

AMGN Risk / Return Rank: 66
AMGN Sharpe Ratio Rank: 69
AMGN Sortino Ratio Rank: 64
AMGN Omega Ratio Rank: 62
AMGN Calmar Ratio Rank: 68
AMGN Martin Ratio Rank: 69

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MSTR vs. AMGN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Strategy Inc (MSTR) and Amgen Inc. (AMGN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MSTR	AMGN	Difference
Sharpe ratio: Return per unit of total volatility	-0.94	0.83	-1.77
Sortino ratio: Return per unit of downside risk	-1.66	1.40	-3.06
Omega ratio: Gain probability vs. loss probability	0.82	1.17	-0.35
Calmar ratio: Return relative to maximum drawdown	-0.86	1.37	-2.24
Martin ratio: Return relative to average drawdown	-1.27	3.21	-4.47
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MSTR vs. AMGN - Sharpe Ratio Comparison

The current MSTR Sharpe Ratio is -0.94, which is lower than the AMGN Sharpe Ratio of 0.83. The chart below compares the historical Sharpe Ratios of MSTR and AMGN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	MSTR	AMGN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.94	0.83	-1.77
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.22	0.47	-0.24
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.29	0.47	-0.18
Sharpe Ratio (All Time) Calculated using the full available price history	0.12	0.61	-0.49

Drawdowns

MSTR vs. AMGN - Drawdown Comparison

The maximum MSTR drawdown since its inception was -99.86%, which is greater than AMGN's maximum drawdown of -63.48%. Use the drawdown chart below to compare losses from any high point for MSTR and AMGN.

Drawdown Indicators

	MSTR	AMGN	Difference
Max Drawdown Largest peak-to-trough decline	-99.86%	-63.48%	-36.38%
Max Drawdown (1Y) Largest decline over 1 year	-76.53%	-16.57%	-59.96%
Max Drawdown (3Y) Largest decline over 3 years	-77.42%	-22.74%	-54.68%
Max Drawdown (5Y) Largest decline over 5 years	-84.11%	-24.86%	-59.25%
Max Drawdown (10Y) Largest decline over 10 years	-89.27%	-24.86%	-64.41%
Current Drawdown Current decline from peak	-73.15%	-10.26%	-62.89%
Average Drawdown Average peak-to-trough decline	-86.47%	-16.78%	-69.69%
Ulcer Index Depth and duration of drawdowns from previous peaks	52.19%	7.09%	+45.10%

Volatility

MSTR vs. AMGN - Volatility Comparison

Strategy Inc (MSTR) has a higher volatility of 21.43% compared to Amgen Inc. (AMGN) at 6.37%. This indicates that MSTR's price experiences larger fluctuations and is considered to be riskier than AMGN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MSTR	AMGN	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.43%	6.37%	+15.06%
Volatility (6M) Calculated over the trailing 6-month period	56.80%	19.14%	+37.66%
Volatility (1Y) Calculated over the trailing 1-year period	70.82%	27.38%	+43.44%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	90.87%	23.89%	+66.98%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	73.77%	24.82%	+48.95%

Dividends

MSTR vs. AMGN - Dividend Comparison

MSTR has not paid dividends to shareholders, while AMGN's dividend yield for the trailing twelve months is around 2.83%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AMGN Amgen Inc.	2.83%	2.91%	3.45%	2.96%	2.95%	3.13%	2.78%	2.41%	2.71%	2.65%	2.74%	1.95%
MSTR Strategy Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both MSTR and AMGN in my portfolio?

MSTR and AMGN have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MSTR or AMGN?

MSTR has higher volatility (21.43%) compared to AMGN (6.37%). In terms of maximum drawdown, MSTR dropped -99.86% vs AMGN's -63.48%.

Which has better risk-adjusted returns?

AMGN currently has the higher Sharpe Ratio (0.83 vs -0.94), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.