AUTL vs. KRYS

Last updated Jun 9, 2026

AUTL (Autolus Therapeutics plc) and KRYS (Krystal Biotech, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, AUTL returned -26.36%/yr vs 35.77%/yr for KRYS. At a 0.29 correlation, their price movements are largely independent.

Performance

AUTL vs. KRYS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Autolus Therapeutics plc (AUTL) and Krystal Biotech, Inc. (KRYS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AUTL achieves a -26.63% return, which is significantly lower than KRYS's 22.40% return.

AUTL

• 1D: -4.58%
• 1M: -7.01%
• YTD: -26.63%
• 6M: -8.18%
• 1Y: -37.61%
• 3Y*: -20.17%
• 5Y*: -26.36%
• 10Y*: —

KRYS

• 1D: 0.25%
• 1M: -1.29%
• YTD: 22.40%
• 6M: 28.93%
• 1Y: 120.36%
• 3Y*: 32.77%
• 5Y*: 35.77%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

AUTL vs. KRYS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
AUTL Autolus Therapeutics plc	-26.63%	-15.32%	-63.51%	238.95%	-63.39%	-41.95%	-32.27%	-59.81%	17.29%
KRYS Krystal Biotech, Inc.	22.40%	57.37%	26.28%	56.60%	13.25%	16.58%	8.34%	166.51%	48.01%

Correlation

The correlation between AUTL and KRYS is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.24
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.32
Correlation (All Time) Calculated using the full available price history since Jun 22, 2018	0.29

Fundamentals

Market Cap AUTL : $388.57M KRYS : $9.21B
EPS AUTL : -$1.09 KRYS : $7.50
PS Ratio AUTL : 4.20 KRYS : 21.70
PB Ratio AUTL : 3.57 KRYS : 7.21
Total Revenue (TTM) AUTL : $92.59M KRYS : $417.30M
Gross Profit (TTM) AUTL : -$10.36M KRYS : $387.24M
EBITDA (TTM) AUTL : -$253.48M KRYS : $185.45M

Return for Risk

AUTL vs. KRYS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AUTL

AUTL Risk / Return Rank: 22
AUTL Sharpe Ratio Rank: 20
AUTL Sortino Ratio Rank: 23
AUTL Omega Ratio Rank: 24
AUTL Calmar Ratio Rank: 16
AUTL Martin Ratio Rank: 23

KRYS

KRYS Risk / Return Rank: 94
KRYS Sharpe Ratio Rank: 96
KRYS Sortino Ratio Rank: 92
KRYS Omega Ratio Rank: 92
KRYS Calmar Ratio Rank: 96
KRYS Martin Ratio Rank: 96

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AUTL vs. KRYS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Autolus Therapeutics plc (AUTL) and Krystal Biotech, Inc. (KRYS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AUTL	KRYS	Difference
Sharpe ratio: Return per unit of total volatility	-0.50	3.12	-3.62
Sortino ratio: Return per unit of downside risk	-0.37	3.42	-3.79
Omega ratio: Gain probability vs. loss probability	0.96	1.47	-0.51
Calmar ratio: Return relative to maximum drawdown	-0.69	7.59	-8.28
Martin ratio: Return relative to average drawdown	-0.96	19.64	-20.61
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AUTL vs. KRYS - Sharpe Ratio Comparison

The current AUTL Sharpe Ratio is -0.50, which is lower than the KRYS Sharpe Ratio of 3.12. The chart below compares the historical Sharpe Ratios of AUTL and KRYS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AUTL	KRYS	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.50	3.12	-3.62
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.34	0.47	-0.81
Sharpe Ratio (All Time) Calculated using the full available price history	-0.37	0.63	-1.01

Drawdowns

AUTL vs. KRYS - Drawdown Comparison

The maximum AUTL drawdown since its inception was -97.63%, which is greater than KRYS's maximum drawdown of -53.42%. Use the drawdown chart below to compare losses from any high point for AUTL and KRYS.

Drawdown Indicators

	AUTL	KRYS	Difference
Max Drawdown Largest peak-to-trough decline	-97.63%	-53.42%	-44.21%
Max Drawdown (1Y) Largest decline over 1 year	-54.85%	-15.94%	-38.91%
Max Drawdown (3Y) Largest decline over 3 years	-84.36%	-42.26%	-42.10%
Max Drawdown (5Y) Largest decline over 5 years	-85.68%	-44.55%	-41.13%
Current Drawdown Current decline from peak	-96.96%	-4.60%	-92.36%
Average Drawdown Average peak-to-trough decline	-81.27%	-16.20%	-65.07%
Ulcer Index Depth and duration of drawdowns from previous peaks	39.02%	6.15%	+32.87%

Volatility

AUTL vs. KRYS - Volatility Comparison

Autolus Therapeutics plc (AUTL) has a higher volatility of 24.19% compared to Krystal Biotech, Inc. (KRYS) at 10.25%. This indicates that AUTL's price experiences larger fluctuations and is considered to be riskier than KRYS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AUTL	KRYS	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.19%	10.25%	+13.94%
Volatility (6M) Calculated over the trailing 6-month period	52.08%	27.29%	+24.79%
Volatility (1Y) Calculated over the trailing 1-year period	75.46%	38.91%	+36.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	77.73%	76.38%	+1.35%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	80.85%	74.19%	+6.66%

Dividends

AUTL vs. KRYS - Dividend Comparison

Neither AUTL nor KRYS has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AUTL and KRYS in my portfolio?

AUTL and KRYS have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AUTL or KRYS?

AUTL has higher volatility (24.19%) compared to KRYS (10.25%). In terms of maximum drawdown, AUTL dropped -97.63% vs KRYS's -53.42%.

Which has better risk-adjusted returns?

KRYS currently has the higher Sharpe Ratio (3.12 vs -0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.